Alzheimer's Disease : A Compendium of Current

The first formal description of Alzheimer's as a distinct neuropathology began a century of research progress that has intensified in the last 20 years with a rich array of new theories, treatments, risk factors, and some possible causes. However, little

Preface

ix

Zaven S. Khachaturian

M.-Marsel Mesulam

Part I. Theories on Structural Changes: Protein Synthesis, Aggregation, and Degradation

A. Pros and Cons of Amyloid

Genetic Factors in the Genesis of Alzheimer's Disease.

1

(7)

P.H. St George-Hyslop

A Very Incomplete Comprehensive Theory of Alzheimer's Disease.

8

(9)

Peter Davies

Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β-Protein.

17

(9)

Dennis J. Selkoe

The Pathogenesis of Alzheimer's Disease: Is Amyloid β-Protein the Beginning or the End?

26

(3)

Bruce A. Yankner

Pathways to Primary Neurodegenerative Disease

29

(6)

John Hardy

Arson: Tracking the Culprit in Alzheimer's Disease.

35

(4)

Mark A. Smith

James A. Joseph

George Perry

Synaptic Structure and Function in Transgenic APP Mice.

39

(3)

Karen Hsiao Ashe

B. Cytoskeleton Proteins and Synapses

A Plasticity-Based Theory of the Pathogenesis of Alzheimer's Disease.

42

(11)

M.-Marsel Mesulam

Vulnerability of Select Neuronal Types to Alzheimer's Disease.

53

(9)

Heiko Braak

KellyDel Tredici

Christian Schultz

Eva Braak

``Fatal Attractions'' of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders.

62

(6)

John Q. Trojanowski

Virginia M.-Y. Lee

The Role of Synaptic Proteins in Alzheimer's Disease.

68

(8)

Eliezer Masliah

The Long Reach of Evolution and Development: Effects on the Alzheimer Brain.

76

(5)

Kenneth S. Kosik

Part II. Theories on Functional Changes

A. Risk Factors: ApoE and Estrogen

Apolipoprotein E and Alzheimer's Disease: A Role in Amyloid Catabolism.

81

(10)

Judes Poirier

Apolipoprotein E and Alzheimer's Disease.

91

(2)

Warren J. Strittmatter

Estrogens and Estrogen-Like Non-Feminizing Compounds: Their Role in the Prevention and Treatment of Alzheimer's Disease.

93

(6)

Pattie S. Green

James W. Simpkins

Alzheimer's Disease and Some Speculations about the Evolution of Its Modifiers.

99

(5)

Robert M. Sapolsky

Caleb E. Finch

B. Trophins, Apoptosis, Proteases, and Inflammation

Comprehensive Theory of Alzheimer's Disease: The Effects of Cholesterol on Membrane Receptor Trafficking.

104

(8)

Casey Lynch

William Mobley

The Brain's Microenvironment, Early Functional Loss, and the Conversion to Alzheimer's Disease.

112

(5)

Carl W. Cotman

Aileen J. Anderson

A ``Protease Activation Cascade'' in the Pathogenesis of Alzheimer's Disease.

117

(15)

Ralph A. Nixon

A Perspective on Inflammation in Alzheimer's Disease.

132

(4)

Joseph Rogers

Yong Shen

Part III. Theories on Energetics: Circulation, Metabolism, and Oxidation

Impaired Cerebromicrovascular Perfusion: Summary of Evidence in Support of Its Causality in Alzheimer's Disease.

136

(17)

J. C. De La Torre

Existing Data Suggest That Alzheimer's Disease Is Preventable.

153

(7)

Mark P. Mattson

Oxidative Stress Leading to Loss of Critical Proteases in Alzheimer's Disease: An Alternative View of the Etiology of AD.

160

(4)

John M. Carney

Oxidative Metabolism.

164

(6)

M. Flint Beal

The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome.

170

(14)

John P. Blass

Part IV. Epilogue

Epilogue: Toward a Comprehensive Theory of Alzheimer's Disease --- Challenges, Caveats, and Parameters.

184

(11)

Zaven S. Khachaturian

Index of Contributors

195

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Alzheimer's Disease : A Compendium of Current Theories

Summary

Table of Contents

Supplemental Materials