Amino Group Chemistry From Synthesis to the

Here, probably the most important functional group in organic chemistry is discussed in one handy volume. The monograph covers its application -- from natural products to synthetic pharmaceuticals -- detailing complex syntheses using the amino group as templates and modern techniques focussing on the introduction of the amino group. A definitive must-have for every chemist.

Alfredo Ricci is full professor in Organic Chemistry at the Chemistry Department of the Faculty of Industrial Chemistry (Bologna University). He was appointed in Florence where he spent part of his career covering for many years the roles of Department head and Director of the National Research Council. 1990 he moved to the University of Bologna. Professor Ricci has authored more than 250 scientific publications and received several scientific awards, including the 2000 French-Italian Prize for Synthetic Organic Chemistry and in 2005 the "A. Mangini" Gold Medal. Since 1995 he is member of the 'Honorary Advisory Board' of Synlett and in 2000 served as editor of the Wiley-VCH book "Modern Amination Methods".

Preface
List of Contributors
Simple Molecules, Highly Effi cient Amination
Introduction
Hydroxylamine Derivatives
Oxime Derivatives
Azo Compounds
Oxaziridine Derivatives
Chloramine-T
N-Sulfonyliminophenyliodinane
Transition Metal-Nitride Complexes
Azido Derivatives
Gabriel-Type Reagents
Conclusion
Catalytic C-H Amination with Nitrenes
Introduction
Historical Overview
Hypervalent Iodine-Mediated C−H Amination
Other Nitrene Precursors for C−H Amination
Amination of Aromatic C−H Bonds
Applications in Total Synthesis
Conclusions
Nitroalkenes as Amination Tools
Introduction
General Strategies for the Synthesis of Nitroalkenes
Synthesis of Alkylamines
Pyrrolidine Derivatives
Piperidines and Piperazines
Pyrrolizidines and Related Derivatives
Arene-Fused Nitrogen Heterocycles
Other Polycyclic Derivatives
Conclusion
Isocyanide-Based Multicomponent Reactions (IMCRs) as a Valuable Tool with which to Synthesize Nitrogen-Containing Compounds
Introduction
The Ugi Reaction
Passerini Reaction
van Leusen Reaction
Other IMCRs
Outlook
Direct Catalytic Asymmetric Mannich Reactions and Surroundings
Introduction
Organometallic Catalysts
Metal-Free Organocatalysis
Conclusions
Amino-Based Building Blocks for the Construction of Biomolecules
Introduction
Propargylamines (PLAs)
trans-4-Hydroxy-(S)-proline (HYP)
L-Serine (SER)
4-Methoxypyridine (MOP)
Aziridines (AZIs)
Homoallylamine (HAM)
Indole (IND)
Conclusion
Aminated Sugars, Synthesis, and Biological Activity
Biological Relevance of Aminated Sugars
Synthesis of Aminated Sugars
Synthesis of Iminosugars
Conclusions
Selective N-Derivatization of Aminoglycosides en Route to New Antibiotics and Antivirals
Aminoglycoside Antibiotics
RNA Targeting by Aminoglycosides
The Role of Amino Functions in RNA Binding
Development of RNA-Targeting Drugs
Concluding Remarks
Evolution of Transition Metal-Catalyzed Amination Reactions: the Industrial Approach
Introduction: First Steps in the Field of Catalytic Aromatic Amination
Alternatives to Transition Metal-Catalyzed Arylamination
The Quest for Industrial Applications of Transition Metal-Catalyzed Arylamination

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Amino Group Chemistry From Synthesis to the Life Sciences

Summary

Author Biography

Table of Contents

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