Annual Plant Reviews, Functions and

This important volume commences with an overview of the modes of action of defensive secondary metabolites, followed by detailed surveys of chemical defense in marine ecosystems, the biochemistry of induced defense, plant-microbe interactions and medical applications. A chapter is also included covering biotechnological aspects of producing valuable secondary metabolites in plant cell and organ cultures. This is a comprehensive and fully updated new edition, edited by Professor Michael Wink and including contributions from many internationally acknowledged experts in the field.

Michael Wink is Professor of Pharmaceutical Biology and Director at the Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Germany.

List of contributors	p. ix
Preface	p. xi
Introduction	p. 1
Ecological function of secondary metabolites	p. 1
Presence of defence and signal compounds at the right time and place	p. 4
Molecular modes of action of SM	p. 8
Biotechnology and utilization of SM	p. 13
Conclusions	p. 16
Molecular Modes of Action of Defensive Secondary Metabolites	p. 21
Introduction	p. 21
Molecular modes of action - an overview	p. 22
Accumulation of defence and signal compounds in plants	p. 128
Animal responses: detoxification mechanisms and adaptations	p. 132
Concluding remarks	p. 137
Chemical Defence in Marine Ecosystems	p. 162
Introduction	p. 162
Marine natural products in allelopathic interactions	p. 165
Chemical defence against fouling	p. 168
Chemical defences of marine invertebrates and algae against consumers	p. 173
Favoured allocation of defensive metabolites in vulnerable and valuable parts of marine invertebrates and algae	p. 182
The flexible response: stress-induced accumulation of defence metabolites and activation of protoxins	p. 186
Endosymbionts as sources for allelochemicals found in marine invertebrates	p. 193
Conclusions and outlook	p. 201
Plant-Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties	p. 214
Introduction	p. 215
Phytoalexins	p. 217
Antibacterial and antifungal agents of higher plants	p. 232
Secondary metabolities from higher plants with antiviral properties	p. 278
Conclusions	p. 317
New Medical Applications of Plant Secondary Metabolites	p. 348
Introduction	p. 349
Compounds with anticancer and chemopreventive activity	p. 349
Antiviral compounds	p. 359
Antimalarial drugs	p. 360
Anti-inflammatory drugs	p. 361
Antidepressant drugs	p. 363
Anti-ischaemic drugs	p. 364
Immunostimulatory drugs	p. 365
Conclusions	p. 366
Production of Natural Products by Plant Cell and Organ Cultures	p. 381
Introduction	p. 381
Production of natural products by cell and organ cultures	p. 383
Elicitation	p. 383
Increase/decrease of product yields by genetic manipulation	p. 384
Biosynthetic pathways delineation using RNA-interference	p. 385
Mass cultivation of plant cell cultures	p. 386
Production of recombinant proteins by plants and plant cell cultures	p. 388
Production of plant natural products in microbes	p. 389
Perspectives	p. 390
Index	p. 399
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Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites

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