Antiangiogenic Cancer Therapy

The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies in cancer research. This work promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis will lead to optimal therapeutic strategies and positive clinical results. It compiles the work of leading experts to explore angiogenesis inhibitors under clinical investigation, as well as early agents used in preclinical studies. It discusses the unique aspects of targeting and inhibiting angiogenesis and the challenges associated with clinical development of angiogenesis inhibitors including trial design and surrogate marker endpoints The chapters are organized to allow readers easy access to the fundamental concepts of angiogenesis and information on the complexities associated with targeting angiogenesis for specific types of cancer.