Antiviral Therapy

Glaxo Wellcome Medicines Research Centre, Stevenage, U.K. A concise summary of information on drug targets and current therapy regimes for all of the major viral infections. For practitioners, health care professionals, students, and researchers. Modified outline format. Softcover. DNLM: Virus Diseases--drug therapy.

Abbreviations

vii

(4)

Preface

xi

1 Development of antiviral chemotherapy

1

(20)

History: The origins of antiviral drug development

1

(1)

Early antivirals

2

(2)

The first nucleoside analogs

4

(2)

The discovery of aciclovir

6

(4)

Ganciclovir and penciclovir

10

(1)

Valaciclovir

10

(1)

Further developments in pyrimidine nucleoside analogs

11

(1)

Nucleoside analogs for the treatment of HIV infection

12

(2)

Nonnucleoside inhibitors of HIV reverse transcriptase

14

(1)

Protease inhibitors of HIV

15

(1)

Other virus infections

16

(3)

Summary

19

(2)

2 Chemotherapy of herpesvirus infections

21

(22)

Introduction: what is a herpesvirus

21

(3)

Herpes simplex virus

24

(3)

Varicella-zoster virus

27

(1)

Human cytomegalovirus

28

(1)

Epstein-Barr virus

29

(1)

Human herpes virus-6

30

(1)

Human herpes virus-7

30

(1)

Human herpes virus-8

30

(1)

History of antiviral therapy

30

(4)

Other antiherpetic agents

34

(7)

Conclusion

41

(1)

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Summary

Table of Contents

Supplemental Materials

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Antiviral Therapy

Summary

Table of Contents

Supplemental Materials

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