Applications of Transition Metal Catalysis in Drug Discovery and Development An Industrial Perspective

This book documents examples of transition metal catalysis in drug discovery and development from an industrial perspective. Co-edited by Barry Trost, one of the foremost organic research chemists, the authors pay particular attention to transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how these processes can deliver new drug candidates. This work provides a unique perspective on the pharmaceutical applications of transition metal catalysis, offering a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

Matthew L. Crawley, PhD, is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents. Barry M. Trost, PhD, is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.