Asthma and Allergic Diseases

, by Marone; Holgate; Kay; Lichtenstein; Austen

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780124733404 | 0124733409
Cover: Hardcover
Copyright: 5/19/1998

eBook

Available Instantly

Online: 1825 Days

Downloadable: Lifetime Access

*To support the delivery of the digital material to you, a digital delivery fee of $3.99 will be charged on each digital item.

$180.00*

This book updates the previous coverage of the mechanisms and mediators of asthma and its treatment. It presents articles by the foremost names in the field. Key Features * Updates the previous coverage of the mechanisms and mediators of asthma and its treatment * Presents articles by the foremost names in the field * Includes over 92 figures and 12 tables

CONTRIBUTORS

xvii

(8)

PREFACE

xxv

(4)

ABBREVIATIONS

xxix

THE GENETICS AND EPIDEMIOLOGY OF ATOPY AND ASTHMA

(56)

Chapter 1 Prospective on the Functional Characteristics of Human LTC(4) Synthase

(10)

Ji-liang Zhao

K. Frank Austen

Bing K. Lam

Introduction

(1)

Biosynthesis of LTC(4)

(1)

Cloning of Human and Mouse LTC(4) Synthase

(1)

The LTC(4)S/mGST-II/FLAP Gene Family

(2)

Regulation of LTC(4) Synthase Expression

(1)

Concluding Comments

(1)

References

(3)

Discussion

(2)

Chapter 2 Genetics and Asthma

(12)

William O. C. M. Cookson

Preamble

(1)

Finding Genes

(1)

Genes Influencing Asthma

(2)

Genes Influencing Specific IgE Responses to Particular Allergens

(2)

Genes Influencing Bronchial Responsiveness

(1)

Genes Influencing Non-IgE-mediated Inflammation

(1)

Whole Genome Screens for Atopy and Asthma

(1)

Conclusions

(1)

References

(2)

Discussion

(3)

Chapter 3 Transcription Factors in Asthma

(22)

Ian M. Adcock

Peter J. Barnes

Introduction

(1)

Basal and Regulated Transcription

(2)

AP-1 Family

(3)

CCAAT Enhancer-binding Proteins (C/EBP) and NF-IL-6

(1)

JAK STAT Family

(2)

Nuclear Factor of Activated T Cells (NF-AT)

(2)

NF-kB

(2)

Glucocorticoid Receptors (GRs)

(1)

Cross-talk Between Transcription Factors and Their Transduction Pathways

(3)

Transcription Factors in Asthma

(2)

References

(2)

Discussion

(2)

Chapter 4 Environmental Factors in the Development of Atopy and Asthma in Children

(12)

U. Wahn

R. Bergmann

S. Lau

E. von Mutius

Outdoor Conditions

(1)

Indoor Conditions

(1)

MAS--The German Birth Cohort Study

(1)

The Natural Course of Sensitization and Atopic Disease

(1)

Indoor Allergen Exposure and Early Sensitization

(4)

The Role of Environmental Tobacco Smoke Exposure

(1)

Conclusions

(1)

References

(1)

Discussion

(3)

SIGNAL TRANSDUCTION IN IMMUNE AND INFLAMMATORY CELLS

(60)

Chapter 5 Expression and Function of the High-affinity Receptor for IgE in Asthma

(60)

Marie-Hélène Jouvin

Jean-Pierre Kinet

Introduction

(3)

Structure and Regulation of Expression of Fc(E)RI

(3)

Mechanisms of FC(E)RI Signalling

(2)

Human FcR(Beta) Polymorphism and Atopy

(1)

References

(4)

Discussion

(3)

Chapter 6 The Role of Basophil-Cytokine Networks in Asthma

(12)

John T. Schroeder

Donald W. MacGlashan, Jr

Lawrence M. Lichtenstein

Introduction

(1)

Cytokine Generation by Human Basophils

(1)

Signal Transduction

(2)

Pharmacological Control

(1)

Parameters of IL-13 Secretion

(2)

Concluding Remarks

(1)

References

(2)

Discussion

(3)

Chapter 7 Regulation of Inflammatory Cytokine Receptor Expression by Pro- and Anti-inflammatory Molecules

(10)

Alberto Mantovani

Antonio Sica

Simona Saccani

Simone Orlando

Nadia Polentarutti

Paola Allavena

Silvano Sozzani

Introduction

(1)

IL-1 Receptors

(3)

Regulation of Chemokine Receptor Expression

(2)

Concluding Remarks

(1)

References

(3)

Discussion

(2)

Chapter 8 The gp49 Family: A New Pathway for the Inhibition of Mast Cell Activation

(10)

Howard R. Katz

Initial Immunological and Immunochemical Description of a Member of the Mouse gp49 Family

(1)

Discovery of a Mouse gp49 Family Through Molecular Cloning

(1)

Genomic Organization of the Mouse gp49 Family

(1)

gp49B1 Belongs to a Newly Recognized and Expanding Receptor Family

100

(1)

Functions of gp49B1

100

(1)

Regulation of Mast Cell Activation: A Counterbalance Between Stimulatory and Inhibitory Cell Surface Receptors

101

(1)

References

102

(2)

Discussion

104

(3)

Chapter 9 Biological Properties of the IgE-dependent Histamine-releasing Factor

107

(12)

Jacqueline M. Langdon

Susan M. MacDonald

Introduction

107

(1)

Effects of HrHRF on the Cells of the LPR

108

(3)

Signal Transduction Studies of the HrHRF

111

(1)

HrHRF's Link to Clinical Disease

112

(1)

Conclusion

113

(1)

References

113

(1)

Discussion

114

(5)

CHEMICAL MEDIATORS IN ALLERGIC DISORDERS

119

(52)

Chapter 10 Mast Cell and Eosinophil Proteases in the Chronic Allergic Inflammatory Response

119

(14)

Andrew F. Walls

Janis K. Shute

Jane Warner

Jennifer A. Cairns

Peter H. Howarth

Stephen T. Holgate

Protease--Anti-protease Balance

119

(1)

Mast Cell Proteases

120

(2)

Eosinophil Proteases

122

(2)

Proteases as Targets for Therapeutic Intervention

124

(1)

References

125

(4)

Discussion

129

(4)

Chapter 11 Remodelling of Arachidonic Acid Pools in Inflammatory Cells Migrating into the Lung

133

(10)

Massimo Triggiani

Guido Rossi

Gianni Marone

Introduction

133

(1)

Arachidonic Acid Remodelling

134

(4)

Concluding Remarks

138

(1)

References

139

(1)

Discussion

140

(3)

Chapter 12 Kinin Actions in the Human Airways: Modulation by Allergic Inflammation

143

(14)

David Proud

Curt J. Reynolds

Joan M. Bathon

Alexander Faussner

Introduction

143

(1)

Kinin Formation in Airway Inflammation

143

(1)

Kinin Properties and Receptor Subtypes

144

(2)

Actions of Kinins in the Airways

146

(3)

Mechanisms of Kinin Actions

149

(2)

Concluding Remarks

151

(1)

References

152

(3)

Discussion

155

(2)

Chapter 13 Chemokines and Chemokine Receptors in Allergic Inflammation

157

(14)

Marco Baggiolini

Mariagrazia Uguccioni

Pius Loetscher

Introduction

157

(2)

Chemokine Structures

159

(1)

The Cells of Allergic Inflammation

159

(1)

Chemokine Receptors

160

(1)

The Chemokines

161

(2)

Conclusions

163

(1)

References

164

(1)

Discussion

165

(6)

MOLECULAR REGULATION OF CYTOKINE GENES

171

(36)

Chapter 14 The Molecular Basis of IL-4 Dysregulation in the Atopic Condition

171

(22)

Steve N. Georas

Thomas F. Burke

Ronghing Chen

John E. Cumberland

Vincenzo Casolaro

Introduction

171

(1)

Factors that Regulate IL-4 Transcription

172

(8)

The IL-4 Promoter

180

(4)

Concluding Remarks

184

(1)

References

185

(5)

Discussion

190

(3)

Chapter 15 Regulation of IL-4, IL-5 and GM-CSF in T Lymphocytes

193

(14)

David J. Cousins

Dontcho Z. Staynov

Tak H. Lee

Introduction

193

(1)

Involvement of IL-4, IL-5 and GM-CSF in Atopic Disease

193

(1)

Regulation of IL-4, IL-5 and GM-CSF Gene Expression in T Cells

194

(4)

Conclusions

198

(1)

References

199

(4)

Discussion

203

(4)

IMMUNE AND INFLAMMATORY CELLS IN ALLERGIC DISORDERS

207

(64)

Chapter 16 T Lymphocytes in Chronic Asthma

207

(16)

A. Barry Kay

Introduction

207

(1)

Activated T Cells

208

(1)

Cytokines

209

(1)

Atopic Versus Non-atopic Asthma

210

(3)

T Cell Homing Receptors

213

(1)

Glucocorticoid Resistance in Asthma

213

(1)

Anti-T Cell Strategies

214

(2)

Further Developments

216

(1)

References

217

(2)

Discussion

219

(4)

Chapter 17 Mast Cells and Asthma

223

(14)

Lawrence B. Schwartz

Background

223

(1)

Tryptase Biochemistry and Biology

223

(3)

Tryptase as a Marker of Mast Cell Involvement in Human Disease

226

(3)

References

229

(4)

Discussion

233

(4)

Chapter 18 Human Cardiac Mast Cells and Their Role in Severe Allergic Reactions

237

(22)

Gianni Marone

Gennaro de Crescenzo

Vincenzo Patella

Arturo Genovese

Introduction

237

(1)

Cardiovascular Alterations in Bronchial Asthma, Anaphylaxis and Allergic Drug Reactions

238

(1)

Cardiac Pathology in Patients with Fatal Asthma

239

(1)

Myocardial Alterations and Deaths Complicating the Use of Drugs in Allergic Patients

239

(2)

Mast Cells in Normal and Diseased Human Heart

241

(1)

Preformed Mediators Synthesized by HHMCs

241

(2)

Lipid Mediators Synthesized de novo by HHMCs

243

(1)

Immunological and Non-immunological Stimuli that Activate HHMCs in vitro

244

(2)

The Roles of HHMCs

246

(3)

Concluding Remarks

249

(1)

References

250

(6)

Discussion

256

(3)

Chapter 19 Novel Glucocorticomimetic Agents Active on Eosinophils: Potential Uses in the Therapy of Asthma

259

(12)

Gerald J. Gleich

Jennifer Bankers-Fulbright

Shinji Okada

Hirohito Kita

Loren W. Hunt

Introduction

259

(1)

Lidocaine as an Inhibitor of Eosinophil-active Cytokines

260

(1)

The Effect of Nebulized Lidocaine on Severe Glucocorticoid-dependent Asthma

260

(3)

Mechanisms of Lidocaine Action

263

(2)

Evidence for an Eosinophil Sulfonylurea Receptor (SUR)

265

(1)

Synergistic Effects of Glucocorticoids, Lidocaine and Glyburide as Inhibitors of IL-5-mediated Eosinophil Survival

266

(1)

Summary and Conclusion

266

(1)

References

267

(1)

Discussion

267

(4)

BIOPHYSICAL AND IMMUNOLOGICAL ALTERATIONS IN ATOPIC PATIENTS

271

(22)

Chapter 20 Biophysical Evaluation of Skin Reactivity in Atopic Patients

271

(10)

Stefania Seidenari

Clinical Evidence of Skin Sensitivity in Atopic Dermatitis

271

(1)

Mucosal Atopy and Irritant Contact Dermatitis

271

(1)

Biophysical Measurements for the Evaluation of Irritant Contact Dermatitis in the Atopic

272

(1)

Baseline Biophysical Parameters of the Skin in Atopic Dermatitis Patients

273

(1)

Alterations of Epidermal Lipids in Atopic Dermatitis Patients

274

(1)

Experimental Evidence of Skin Hyperirritability in the Atopic

274

(3)

References

277

(1)

Discussion

278

(3)

Chapter 21 The Role of Allergen-specific B Cells and IgE in the Development of Allergen-driven Airway Hyper-responsiveness

281

(12)

Erwin W. Gelfand

Gideon Lack

Akihiro Oshiba

Eckard Hamelmann

Introduction

281

(1)

Mode of Sensitization and Challenge

282

(1)

Passive Sensitization with IgE or IgG1

282

(1)

Adoptive Transfer of Antigen-specific B Cells

283

(1)

Allergic Airway Sensitization in B Cell-deficient Mice

283

(2)

Conclusions

285

(1)

References

286

(1)

Discussion

287

(6)

CYTOKINES AND INFLAMMATION IN THE AIRWAYS

293

(44)

Chapter 22 The Role of Rhinoviruses in Virus-induced Asthma

293

(16)

James E. Gern

Robert F. Lemanske, Jr

William W. Busse

Epidemiology of Viral Infections and Asthma

293

(1)

Interactions Between Viruses and Existing Allergic Airway Disease

294

(5)

Possible Mechanisms for Interaction of Viral Infection and Allergy

299

(4)

Concluding Remarks

303

(1)

References

304

(2)

Discussion

306

(3)

Chapter 23 Molecular Events in Allergic Inflammation: Expression of Adhesion Molecules and Their Modulation

309

(12)

Giorgio Ciprandi

Giovanni Passalacqua

Bruno Azzarone

Marcello Bagnasco

Giorgio Walter Canonica

Recent Insights into Allergic Inflammation and Adhesion Molecules

309

(3)

Eye and Nose: The Models

312

(2)

Recent Results Regarding CAM Modulation

314

(2)

Conclusions

316

(1)

References

316

(3)

Discussion

319

(2)

Chapter 24 The Prevalence of Common Respiratory Viruses in Human Lungs

321

(16)

James C. Hogg

Vasilija Macek

Azzeddine Dakhama

Shizu Hayashi

Richard G. Hegele

Introduction

321

(1)

Experimental Approach

321

(5)

Results

326

(1)

Discussion

327

(3)

References

330

(2)

Discussion

332

(5)

PROSPECTIVES IN THERAPY OF ALLERGIC DISORDERS

337

(54)

Chapter 25 Regulation of Allergic Airways Inflammation by Cytokines and Glucocorticoids

337

(20)

Robert P. Schleimer

Qutayba Hamid

Introduction

337

(3)

Regulation of Mast Cell Responses by Cytokines and Glucocorticoids

340

(2)

Cytokines as Targets of Glucocorticoids in the Regulation of Late Phase Cellular Recruitment

342

(6)

Localization of Eosinophils at the Mucosal Surface

348

(1)

Summary

348

(1)

References

349

(5)

Discussion

354

(3)

Chapter 26 Interfering with the 5-Lipoxygenase Pathway as a Novel Way to Treat Asthma

357

(8)

Jeffrey M. Drazen

Introduction

357

(1)

Biochemistry of Leukotriene Formation

357

(2)

Effects of Leukotriene Receptor Antagonists and Synthesis Inhibitors on Laboratory-induced and Spontaneously Occurring Asthma

359

(2)

Summary

361

(1)

References

362

(3)

Chapter 27 New Aspects of Antihistamines in the Treatment of Asthma

365

(10)

J. Andrew Grant

Introduction

365

(1)

Pharmacotherapy of Asthma

366

(4)

Summary

370

(1)

References

370

(3)

Discussion

373

(2)

Chapter 28 DNA Antisense Therapy for Asthma

375

(16)

W. James Metzger

Jonathan A. Nyce

Introduction

375

(1)

Pathophysiology of Asthma

376

(3)

Antisense for Allergic Asthma

379

(4)

Future of Antisense Therapy

383

(1)

References

383

(2)

Discussion

385

(6)

PROSPECTIVES IN IMMUNOTHERAPY OF ALLERGIC DISORDERS

391

(40)

Chapter 29 Perspectives in Antigen-specific Treatment

391

(16)

Thomas A. E. Platts-Mills

Judith A. Woodfolk

Alisa M. Smith

Melody C. Carter

George W. Ward, Jr

Introduction

391

(1)

Increased Exposure to Allergens and Increased Asthma

392

(2)

Allergen Avoidance as an Anti-inflammatory Treatment

394

(1)

Is It Possible to Target the T Cell Component of the Immune Response to Inhaled Allergens?

395

(1)

Trichophyton as a Model of an Intrinsic Allergen

396

(1)

Discussion

397

(2)

Conclusions

399

(1)

References

400

(3)

Discussion

403

(4)

Chapter 30 Peptide Downregulation of the Immune Response

407

(10)

Peter S. Creticos

Introduction

407

(1)

Effects of Immunotherapy on the Allergic Response

407

(2)

Effects of Tolerogenic T Cell Epitope-derived Peptide Immunotherapy

409

(1)

Clinical Studies of Immunotherapy with Cat-derived Peptides

409

(2)

Clinical Studies of Immunotherapy with Ragweed-derived Peptides

411

(1)

Conclusion

412

(1)

References

413

(1)

Discussion

414

(3)

Chapter 31 Immune Deviation of the Allergic Response by DNA Immunization

417

(14)

Eyal Raz

Gene Vaccination: An Overview

417

(1)

Gene Vaccination Induces an Antigen-specific Th1 Response

418

(1)

Gene Vaccination Inhibits Subsequent Induction of a Th2 Response

419

(1)

Gene Vaccination Induces a Th1 Response Despite an On-going Th2 Response

420

(2)

Cytokine Profile of Gene-vaccinated Animals

422

(1)

Gene Vaccination Inhibits Pulmonary Eosinophilic Inflammation

423

(1)

The Immunostimulatory (IS) Effect of Specific DNA Sequences (ISS)

424

(2)

Summary

426

(1)

References

426

(2)

Discussion

428

(3)

Index

431

Please wait while the item is added to your bag...

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Asthma and Allergic Diseases

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Asthma and Allergic Diseases

Summary

Table of Contents

Supplemental Materials

Digital License