Atlas of Clinical Endocrinology, Diabetes

The Atlas of Endocrinology series includes five lavishly illustrated volumes in which outstanding experts have contributed state of the art information and expert perspectives on current topics in the field. The series provides a detailed and comprehensive visual exposition of all aspects of clinical endocrinology.

Stanley Korenman is the author of Atlas of Clinical Endocrinology, Volume 2, Diabetes, published by Wiley. Carl Ronald Kahn is an American physician and scientist, best known for his work with insulin receptors and insulin resistance in diabetes and obesity.

Regulation of Insulin Secretion and Islet Cell Function

Gordon C. Weir

Susan Bonner-Weir

Arun Sharma

Anatomy, Embryology, and Physiology

2

(7)

Insulin Secretion in Type 2 Diabetes

9

(7)

The Mechanisms of Insulin Action

Domenico Accili

Hiroko Kanno

Insulin Receptor

16

(1)

Overview of Insulin Effects

16

(2)

Role of Insulin Receptor Substrate Proteins in Insulin Signaling

18

(2)

Effectors of Insulin Action Downstream from Insulin Receptor Substrate

20

(2)

Alternative Signaling Pathways

22

(1)

Insulin Action on Glucose Metabolism

22

(3)

Other Actions of Insulin

25

(1)

Modulation of Insulin Action

26

(4)

Consequences of Insulin Deficiency

Abbas E. Kitabchi

Structure of the Islets of Langerhans

30

(2)

Definition and Criteria for Insulin-Deficient State

32

(3)

Pathophysiology of Insulin-Deficient State

35

(2)

Treatment of Acute Diabetic Complications

37

(8)

Type I Diabetes

Mark A. Atkinson

Clinical Description

45

(1)

Epidemiology

46

(2)

Genetics

48

(1)

Pathology

49

(8)

Future Directions

57

(3)

Management and Prevention of Complications in Type I Diabetes Mellitus

David M. Nathan

History of Type I Diabetes and Its Treatment

60

(1)

Therapy for Type I Diabetes

60

(3)

Results of Therapy:Glycemia

63

(1)

Long-term Complications: Pathophysiology and Results of Intensive Therapy

64

(3)

New Approaches to Therapy

67

(5)

The Pathogenesis of Type 2 Non-Insulin-Dependent Diabetes

C. Ronald Kahn

Pathogenesis of Type 2 Non-Insulin-Dependent Diabetes

72

(1)

The Role of Genes and the Environment

73

(3)

Insulin Action and Insulin Resistance at the Molecular Level

76

(3)

The Molecular Mechanisms of Insulin Resistance

79

(2)

The Physiologic Basis for Treatment of Type 2 Diabetes

81

(3)

Management and Prevention of Diabetic Complications

Sunder R. Mudaliar

Robert R. Henry

Complications of Diabetes

84

(9)

Future Directions

93

(2)

Insulin Resistance

Ele Ferrannini

Definition and Measurement

95

(2)

Insulin Action

97

(3)

Insulin Resistance

100

(4)

Insulin Resistance Syndrome

104

(6)

Hypoglycemia

John Service

Symptoms, Classification, and Glucose Behavior in Hypoglycemic Disorders

110

(9)

Survival Rates and Recurrence

119

(2)

Mechanisms of Hyperglycemic Damage in Diabetes

Michael Brownlee

Target-Organ Specificity of Hyperglycemic Damage

121

(1)

Major Mechanisms of Hyperglycemic Damage

122

(7)

Interrelationship of Mechanisms of Hyperglycemic Damage

129

(1)

Potential Role of Insulin Resistance

130

(1)

Genetics of Susceptibility to Complications

131

(1)

Development of Complications During Posthyperglycemic Euglycemia

131

(4)

Eye Complications of Diabetes

Lloyd Paul Aiello

Anatomy, Symptoms, and Pathology

135

(2)

Nonproliferative Diabetic Retinopathy

137

(2)

Proliferative Diabetic Retinopathy and Macular Edema

139

(2)

Complications and Causes of Visual Loss

141

(3)

Treatment

144

(4)

Growth Factors and Potential Novel Therapies

148

(3)

Diabetes and the Kidney

Robert C. Stanton

Demographics and Incidence

151

(1)

Diabetic Nephropathy Diagnosis

152

(6)

Treatment and Prevention

158

(6)

Diabetic Neuropathies

Aaron Vinik

Pathogenesis

164

(1)

Mononeuropathy and Entrapment

165

(1)

Distal Neuropathy

166

(1)

Components of Cutaneous Nerve

166

(1)

Large Fiber Neuropathy

167

(2)

C-Fiber Dysfunction in Small Fiber Neuropathy

169

(2)

Neuroarthropathy

171

(1)

Autonomic Neuropathy

172

(2)

Gastropathy

174

(6)

Secondary Forms of Diabetes

Veronica M. Catanese

Abnormal Glucose Homeostasis Secondary to Endocrinologic Disorders: Acromegaly

180

(1)

Cushing Syndrome

181

(2)

Glucagonoma

183

(1)

Pheochromocytoma

184

(1)

Thyrotoxicosis

185

(1)

Hyperprolactinemia

185

(1)

Pancreatoprivic Diabetes: Pancreatectomy and Chronic Pancreatitis

186

(1)

Hemochromatosis

186

(1)

Pharmacologic Effects on Glucose Homeostasis

187

(1)

Genetic Syndromes Affecting Glucose Tolerance

188

(3)

Obesity

Eleftheria Maratos-Flier

Prevalence of Obesity

191

(1)

Obesity and the Risk for Other Diseases

192

(1)

Role of Molecular Mechanisms

192

(2)

Role of Monogenic Mechanisms

194

(5)

Treatment of Obesity

199

(3)

Relative Risk for Obesity

202

(3)

Index

205

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Atlas of Clinical Endocrinology, Diabetes

Summary

Author Biography

Table of Contents

Supplemental Materials