Autism: Oxidative Stress, Inflammation, and

Recently, the CDC issued an alert indicating that autism may impact one out of every150 children. While the syndrome is still officially labeled as idiopathic, research shows the cause of autism may possess genetic, environmental, and possibly immunological factors and that it has at least a correlation to oxidative stress. This book collects work from researchers who report on evidence indicating links between autism and a number of oxidative stress-related abnormalities such as neuroinflammation, mitochondrial dysfunction, membrane and metabolism abnormalities, and signal transduction. The text also reports on potential avenues for new therapeutic intervention strategies.

Preface	p. xi
Editors	p. xvi
Contributors	p. xix
Type, Topography, and Sequelae of Neuropathological Changes Shaping Clinical Phenotype of Autism	p. 1
Evidence for Oxidative Damage in the Autistic Brain	p. 35
Oxidative Stress and Neurotrophin Signaling in Autism	p. 47
Genetics of Autism	p. 61
Phenotypic Expression of Autism, Maternal Depression, and the Monoamine Oxidase-A Gene	p. 73
Paraoxonase 1 Status, Environmental Exposures, and Oxidative Stress in Autism Spectrum Disorders	p. 91
The Redox/Methylation Hypothesis of Autism: A Molecular Mechanism for Heavy Metal-Induced Neurotoxicity	p. 113
Autism and Oxidative Stress: Evidence from an Animal Model	p. 131
Neurotoxic Brainstem Impairment as Proposed Threshold Event in Autistic Regression	p. 153
Abnormalities in Membrane Lipids, Membrane-Associated Proteins, and Signal Transduction in Autism	p. 177
Mitochondrial Component of Calcium Signaling Abnormality in Autism	p. 207
Inflammation and Neuroimmunity in the Pathogenesis of Autism: Neural and Immune Network Interactions	p. 225
Possible Impact of Innate Immunity on Autism	p. 245
Autism, Gastrointestinal Disturbance, and Immune Dysfunction: What Is the Link	p. 277
Possible Mechanism Involving Intestinal Oxytocin, Oxidative Stress, and Signaling Pathways in a Subset of Autism with Gut Symptoms	p. 299
Cytokine Polymorphisms in Autism: Their Role in Immune Alterations	p. 315
Autism, Teratogenic Alleles, HLA-DR4, and Immune Function	p. 325
Autism: The Centrality of Active Pathophysiology and the Shift from Static to Chronic Dynamic Encephalopathy	p. 343
A Reevaluation of the State of Autism Treatment: The Need for a Biopsychosocial Perspective	p. 389
Index	p. 419
Table of Contents provided by Ingram. All Rights Reserved.

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Autism: Oxidative Stress, Inflammation, and Immune Abnormalities

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