Bacterial Virulence Basic Principles, Models and Global Approaches

Starting with basic principles, this reference and handbook discusses examples of the most advanced models of bacterial infection with regard to their value as paradigms to understand the molecular cross talks between microbes and their host and tissue targets. It adopts a very forward-looking, advanced approach, placing special emphasis on the main global challenges facing scientists today, such as pathogenicity vs. commensalisms, infections in immunocompromised hosts and species speciFicity issues.Bacterial Virulence: Basic Principles, Models and Global Approaches is the second title in Wiley-Blackwell's 'Infection Biology Handbook Series'. The first is Aids and Tuberculosis: A Deadly Liaison, edited by two of the most accomplished experts in this area, Prof. Dr. Dr. h.c. Stefan Kaufmann at the Max-Planck Institute for infectious diseases in Berlin, Germany, and Prof. Dr. Bruce Walker, director of the Ragon Institute of MGH, MIT and Harvard in Boston, USA.

Professor Sansonetti received his M.D. in 1979 from the University of Paris. From 1979 to 1981, he conducted research in the Department of Enteric Infections at the Walter Reed Army Institute of Research in the United States. He is a Chevalier de la L?gion d'Honneur and received the Prix d'Excellence Jacques Monod en Biologie Mol?culaire, the Prix AGIR du Conseil Pasteur-Weitzmann, the Grand Prix de l'Acad?mie de M?decine, the Prix Louis Jeantet de M?decine, and the Robert Koch Prize and Medal. He is a member of the French Academy of Science and a corresponding member of the French Academy of Medicine. In 2007, he was elected to the American Academy of Arts and Sciences. He is currently professor at the Institute Pasteur and head of the Unit? de Pathog?nie Microbienne Mol?culaire at the Pasteur Institute of Paris.