Biological Physics

, by Duplantier, Bertrand; Rivasseau, Vincent

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ISBN: 9783034604277 | 3034604270
Cover: Hardcover
Copyright: 12/30/2010

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The book contains articles from leading experts in different areas of biophysics. Topics ranging from cell dynamics to the evolution of multicellularity to conscious versus non-conscious evidence accumulation are reviewed and discussed, both from a theoretical and an experimental perspective. Furthermore, current developments of practical applications like magnetic tweezers for the study of DNA replication and brain imaging are presented.

Foreword	p. ix
Constructing Tools for the Description of Cell Dynamics
Introduction	p. 1
Hydrodynamic theory of active gels	p. 2
Material science aspects	p. 5
Cell motility	p. 9
Cell oscillations	p. 16
Wound healing and cytokinesis	p. 21
Conclusion	p. 28
References	p. 30
A Physical Model of Cellular Symmetry Breaking
Introduction	p. 33
The actin cortex and polarization	p. 34
Build-up and release of tension in actin cortices grown around beads	p. 36
Modeling of actin shell growth and rupture around beads	p. 38
Comparison of symmetry breaking in cells and around beads	p. 40
Symmetry can break from one point or from multiple points	p. 41
Stress-induced polarization in other systems	p. 42
Conclusion	p. 43
References	p. 43
Motor Proteins as Nanomachines: The Roles of Thermal Fluctuations in Generating Force and Motion
The force-generation problem	p. 47
Rectified-diffusion model	p. 49
Flashing-ratchet model	p. 51
Huxley 1957 and powerstroke models	p. 52
Hand-over-hand models	p. 55
Open questions	p. 56
References	p. 57
Fluctuation Relations for Molecular Motors
Introduction	p. 61
Stochastic models of molecular motors	p. 63
Fluctuation relations in models of molecular motors	p. 74
Conclusions	p. 84
References	p. 85
Studies of DNA-Replication at the Single Molecule Level Using Magnetic Tweezers
Introduction	p. 89
Magnetic tweezers	p. 90
How stretching and twisting DNA helps to track replication process	p. 93
Study of the Replisome	p. 98
Characterizing the helicase activity	p. 101
Behaviour of the primosome: coupling activity of the helicase and the primase	p. 107
DNA synthesis	p. 114
Conclusions	p. 118
References	p. 119
Evolution of Biological Complexity
Introduction	p. 123
Volvox and its relatives as model organisms	p. 125
The advection-diffusion problem	p. 127
Allometric scaling of flagella-driven flows	p. 129
Phototactic steering	p. 133
Flagellar synchronization	p. 134
Conclusions	p. 137
References	p. 137
Conscious and Nonconscious Processes: Distinct Forms of Evidence Accumulation?
An experimental strategy for exploring consciousnes	p. 141
How do we measure whether conscious access occurred?	p. 142
Subliminal processing and evidence accumulation models	p. 144
Subliminal perception	p. 145
Subliminal semantic processing	p. 147
Subliminal accumulation of evidence towards a decision	p. 147
Role of instruction and attention in subliminal processing	p. 149
Modulation by instructions	p. 150
Modulation by executive attention	p. 150
Modulation of subliminal priming by temporal attention	p. 150
Modulation by spatial attention	p. 152
Recent evidence for extended subliminal processing	p. 152
Limits to subliminal processing	p. 153
Durable and explicit information maintenance	p. 154
Global access and novel combinations of operations	p. 154
Intentional action	p. 155
Cerebral bases of conscious and nonconscious computations	p. 155
A global workspace model of conscious access	p. 157
Accounting for subliminal processing	p. 160
A distinct state of preconscious processing	p. 161
Conclusion: Conscious access as a solution to von Neumann's problem?	p. 163
References	p. 164
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Biological Physics

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