Biological Small Angle Scattering Theory and Practice

Eaton E. Lattman, Professor of Structural Biology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY,Thomas D. Grant, Staff Scientist, BioXFEL Science and Technology Center, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY,Edward H. Snell, President and Chief Executive Officer, Hauptman-Woodward Medical Research Institute

Eaton Lattman received a BA degree from Harvard College in Chemistry and Physics, and a PhD degree from the Johns Hopkins University in Biophysics. He went on to spend many years at Johns Hopkins, rising through the ranks to become Professor, Departmental Chair, and Dean of Research and Graduate Education. He is currently Professor of Structural Biology in the School of Medicine and Biomedical Sciences, University at Buffalo, SUNY. He has published many papers in the area of structural biology, including a number on methods development.



Thomas Grant received a B.S. degree from the University at Buffalo in Mathematical Physics and a PhD from the University at Buffalo in Structural Biology. After a post-doc at the Hauptman-Woodward Institute, he became a Staff Scientist as part of the NSF Science and Technology Center known as BioXFEL through the University at Buffalo.

Edward Snell received a B.Sc. Hons. Degree from the John Moore University of Liverpool, UK, in Applied Physics and a Ph.D. from the University of Manchester, UK, in the Chemistry Department. He was a National Science Foundation Research Fellow at the NASA Laboratory for Biophysics at Marshall Space Flight Center in Huntsville, Alabama, USA and later as a staff scientist in the same laboratory. Since 2005, he has been at the Hauptman-Woodward Medical Research Institute in Buffalo NY and serves as the current President and Chief Executive Officer.

PART I: INTRODUCTION
1. Introduction
PART II: THEORY OF SMALL ANGLE SCATTERING
2. Theoretical Background
3. Quantities directly measurable by Scattering
4. Three-Dimensional Modeling of SAXS Data
PART III: PRACTICAL ASPECTS OF SMALL ANGLE SCATTERING
5. Before the beamtime
6. During the beamtime
7. Analysis after the beamtime
8. Worked Examples of Data Collection, Processing, and Analysis
9. Dealing with imperfect samples
10. SAXS Instrumentation
11. High-throughput approaches to SAXS
12. Small Angle Neutron Scattering
PART IV: APPLICATIONS PAST, PRESENT, AND FUTURE
13. Examples of Biological Small Angle Scattering
14. Developments on the Horizon
15. Epilogue