Biomedical Applications of Extracellular Vesicles

explains in detail how extracellular vesicles are produced, endocytosed, and the mechanisms by which molecules play biological roles in the treatment of various diseases.

Dr. Zhenhua Li is the Professor of Southern Medical University, China and his Ph.D. degrees are from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. His research focus on the design of biomimetic materials for cancer therapy and regenerative medicine. Prof. Zhenhua Li has authored >90 publications including Nature Nanotechnology, Nature Biomedical Engineering, Science Advances, Nature Communications. His works have been cited over 4800 times so far and H-index is 42. He is a guest editor of Frontiers in Cardiovascular Medicine and Chemistry, and an editorial board member of Chinese Chemical Letters and Exploration.

Dr. Xing-Jie Liang got his Ph.D at National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences. He finished his postdoc with Dr. Michael M. Gottesman (Deputy Director of NIH, USA and Academician member of US national academy of sciences) for 5 years at Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Then, he worked as a Research Fellow at Surgical Neurology Branch, NINDS (National Institute of Neurological Diseases and Strokes, NIH) for 2 years. In 2007, he was an Assistant professor at Department of Radiology, School of Medicine, Howard University. Dr. Liang currently is deputy director of Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences and Lab Chief of Laboratory of Controllable Nanopharmaceuticals, National Center for Nanoscience and Technology of China. He is also leading a group on nanopharmaceuticals at the CAS Center for Excellence in Nanoscience and Chief Lecture Professor of Nanobiology at University of Chinese Academy of Sciences.

Ke Cheng is Professor in the Department of Molecular Biomedical Sciences at the College of Veterinary Medicine and Professor in the UNC/NCSU joint Department of Biomedical Engineering. He is also an adjunct professor at the UNC Eshelman School of Pharmacy and UNC School of Medicine. His research focuses on the development of novel nano theranostic agents for regenerative medicine as well as bioengineering approaches to augment stem cell engraftment and potency.

1 Introduction
2 Exosome biogenesis and identification
3 Biological applications of exosomes from different cell sources
4 Therapeutic potential of extracellular vesicles in treatment of disease
5 Applications of engineered extracellular vesicles
6 Current technology for extracellular vesicles production, isolation and quality control
7 Prospects and limitations of clinical application of exosomes
8 Conclusion and future perspectives