Bone Marrow Diagnosis An Illustrated Guide

Bone Marrow Diagnosis is an essential resource for all those who need to report bone marrow trephine biopsies. The text will be succinct and concentrates on the core information necessary to make an accurate diagnosis. Each diagnostic entity will be accompanied by high quality images which show typical and more unusual examples of histological features.

Each section will be comprehensively revised by an international team of authors. Over 900 high quality colour images will accompany each diagnostic entity. There will be coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias, as well as incorporating new WHO classification of lymphomas and leukaemias.

The digitally photographed and remastered images in this new edition will be of the highest quality, put onto disk directly from the microscope in digital format and reproduced in print form. The text will give comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. It will cover the disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Chapters close with a summary of key points. The consistent approach to describing each condition makes this a valuable reference tool for the trainee and practicing histopathologists, pathologists and haematologists.

Kevin C Gatter, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UKKevin Gatter is Professor of Pathology and Head of the Nuffield Department of Clinical Laboratory Sciences at the John Radcliffe Hospital. He has published textbooks on bone marrow diagnosis, skin lymphoma and lymphoma classification. His research interests include lymphoma diagnosis, medical informatics and angiogenesis in malignancy.
He is honorary director of the ICRF Tumour Pathology Unit and Honorary Consultant in Pathology at the John Radcliffe Hospital.

Preface to the third edition vi

Preface to the first edition vii

1 Introduction 1

2 The normal bone marrow 4

3 Infections including human immunodeficiency virus 18

4 Anaemias and aplasias 32

5 The myelodysplastic syndromes 42

6 Myeloproliferative neoplasms 49

7 Acute leukaemia 69

8 Lymphomas: an overview 89

9 Precursor B and T lymphoblastic leukaemia (acute lymphoblastic leukaemia) and lymphoblastic lymphoma 101

10 Mature B cell neoplasms 108

11 Mature T and NK cell neoplasms 161

12 Hodgkin lymphoma 179

13 Metastatic disease 188

14 Bone stroma and miscellaneous changes 196

15 Technical considerations 209

Index 215

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