Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

, by Bradley; Harris; Jenner; Engel, Jr.; Schwartzkroin; Moshé; Lowenstein

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780123668455 | 012366845X
Cover: Hardcover
Copyright: 11/28/2000

eBook

Available Instantly

Online: 1825 Days

Downloadable: Lifetime Access

*To support the delivery of the digital material to you, a digital delivery fee of $3.99 will be charged on each digital item.

$237.60*

This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.

Contributors

Preface

xix

Acknowledgments

xxi

Mechanisms of Brain Plasticity: From Normal Brain Function to Pathology

Philip A. Schwartzkroin

Introduction

(3)

Relationships between Neuropathology and Plasticity

(6)

Summary

(7)

References

(7)

Brain Development and Generation of Brain Pathologies

Gregory L. Holmes

Bridget McCabe

Introduction

(1)

Timing of Brain Development and Pathology

(5)

Activity-Dependent Alterations in Brain Development and Function

(12)

Summary

(9)

References

(8)

Maturation of Channels and Receptors: Consequences for Excitability

David F. Owens

Arnold R. Kriegstein

Introduction

(1)

Neocortical Development

(2)

Neocortical Organization

(3)

Channels and Receptors

(18)

Synapse Maturation

(2)

Epilepsy

(3)

Concluding Remarks

(17)

References

(16)

Neuronal Activity and the Establishment of Normal and Epileptic Circuits during Brain Development

John W. Swann

Karen L. Smith

Chong L. Lee

Introduction

(1)

The Formation of Synaptic Connections

(2)

Activity-Dependent Remodeling of Connectivity: Underlying Mechanisms

(3)

Age-Dependent Changes in Seizure Susceptibility

(1)

The Ontogeny of Recurrent Excitation

(1)

Developmental Remodeling of CA3 Recurrent Excitatory Collaterals

(3)

Activity and the Formation of Epileptic Circuits

100

(2)

Hippocampal Local Circuit: Abnormalities Expressed in Vitro

102

(2)

Anatomical Abnormalities of CA3c Hippocampal Pyramidal Cells

104

(3)

Dendritic Spine loss: Hypothetical Mechanisms

107

(6)

Summary and Conclusions

113

(6)

References

114

(5)

The Effects of Seizures on the Hippocampus of the Immature Brain

Ellen F. Sperber

Solomon L. Moshe

Introduction

119

(3)

Identification of the Research Questions

122

(1)

Do Provoked Seizures Lead to Hippocampal Injury in the Normal Animal

123

(6)

Do Provoked Seizures Lead to Hippocampal Injury in the Neurologically Impaired Animal?

129

(3)

Can Recurrent Convulsions Accentuate Hippocampal Injury?

132

(1)

Summary and Future Direction

133

(8)

References

135

(6)

Abnormal Development and Catastrophic Epilepsies: The Clinical Picture and Relation to Neuroimaging

Harry T. Chugani

Diane C. Chugani

Introduction

141

(1)

Cerebral Dysgenesis

142

(8)

Lennox-Gastaut Syndrome

150

(1)

Neurocutaneous Syndromes

151

(3)

Conclusion

154

(5)

References

155

(4)

Cortical Reorganization and Seizure Generation in Dysplastic Cortex

G. Avanzini

R. Spreafico

S. Franceschetti

G. Sancini

G. Battaglia

V. Scaioli

Introduction

159

(1)

Circuitry Rearrangement in Human Dysplastic Tissue

160

(2)

Reorganization of Sensory Representation in Cerebral Dysgeneses

162

(3)

Aberrant Connectivity of Heterotopic Neurons in Rats Treated Prenatally with Methylazoxymethanol

165

(4)

Conclusions

169

(4)

References

171

(2)

Rasmussen's Syndrome with Particular Reference to Cerebral Plasticity: A Tribute to Frank Morrell

Frederick Andermann

Yvonne Hart

Introduction

173

(3)

Pathological Studies

176

(1)

Double Pathology in Rasmussen's Syndrome

177

(1)

Bilateral Hemispheric Involvement in Rasmussen's Syndrome

178

(1)

Early-Onset Bilateral and Familial Rasmussen's Syndrome

179

(1)

Rasmussen's Syndrome Developing in Adults or Adolescents

179

(1)

Etiology of Rasmussen's Syndrome

180

(3)

Diagnosis and Investigation

183

(14)

Clinical Course

197

(1)

Treatment

197

(12)

References

204

(5)

Structural Reorganization of Hippocampal Networks Caused by Seizure Activity

Daniel H. Lowenstein

Introduction

209

(1)

The Effects of Seizures on Neuronal Survival

210

(7)

The Effects of Seizures on Axonal Architecture

217

(5)

The Effects of Seizures on New Cell Birth

222

(6)

Conclusions

228

(9)

References

228

(9)

Epilepsy-Associated Plasticity in γ-Aminobutyric Acid Receptor Expression, Function, and Inhibitory Synaptic Properties

Douglas A. Coulter

Introduction

237

(3)

Acute GABA Inhibitory Alterations during Status Epilepticus

240

(1)

Chronic GABA Inhibitory Alterations in Epileptic Hippocampus

241

(6)

Latent Period GABA Inhibitory Alterations in Hippocampus prior to the Onset of Spontaneous Seizures

247

(1)

Summary

248

(5)

References

249

(4)

Synaptic Plasticity and Secondary Epileptogenesis

Timothy J. Teyler

Steven L. Morgan

Rebecca N. Russell

Brian L. Woodside

Introduction

253

(1)

Synaptic Plasticity

254

(1)

Forms of Long-Term Potentiation

254

(4)

Role of Neurotrophins in Long-Term Potentiation and Epilepsy

258

(2)

Functional Significance of Two Forms of Long-Term Potentiation

260

(1)

Secondary Epileptogenesis

261

(2)

Possible Role of vdccLTP in Secondary Epileptogenesis

263

(6)

References

265

(4)

Synaptic Plasticity in Epileptogenesis: Cellular Mechanisms Underlying Long-Lasting Synaptic Modifications That Require New Gene Expression

Oswald Steward

Christopher S. Wallace

Paul F. Worley

Introduction

269

(2)

Long-Term Potentiation: A Paradigm for Elucidating the Cellular and Molecular Mechanisms of Activity-Induced Epilepsy

271

(3)

Constraints on the Cellular Mechanisms Underlying Synaptic Modifications That Require Protein Synthesis

274

(2)

Synapse-Specific Gene Expression

276

(2)

Regulation of mRNA Translation at Synapses

278

(3)

Synaptic Regulation of mRNA Trafficking Dendrites

281

(7)

Lesson from the Study of Arc: A Cellular Basis for Protein Synthesis-Dependent Synaptic Modification

288

(1)

Activity-Induced Gene Expression: A Potential Target for Novel Therapeutic Interventions to Block Epileptogenesis

289

(4)

References

291

(2)

Cellular Correlates of Behavior

Emma R. Wood

Paul A. Dudchenko

Howard Eichenbaum

Introduction

293

(1)

Hippocampal Activity Reflects Spatial Regularities When Behavior Is Randomized

294

(1)

Hippocampal Cell Activity Is Influenced by Behavioral Regularities Occurring in a Given Location

295

(2)

Place Cells Can Fire in Multiple Locations in, the Same Environment

297

(5)

Can These Data Be Accounted for by the Traditional Spatial Hypothesis?

302

(2)

An Alternative Interpretation

304

(2)

One Test of the Regularity versus Spatial Mapping Accounts of Hippocampal Cell Coding

306

(3)

Summary and Closing Thoughts

309

(4)

References

309

(4)

Mechanisms of Neuronal Conditioning

David A. T. King

David J. Krupa

Michael R. Foy

Richard F. Thompson

Introduction

313

(4)

Cerebellar Cortical Lesions

317

(1)

The Locus of the Long Term Memory Trace in Eyeblink Conditioning

318

(3)

Cerebellar Purkinje Cell Activity

321

(2)

Purkinje Cell Complex-Spike Responses

323

(2)

Purkinje Cell Simple-Spike Responses

325

(8)

Conclusion

333

(6)

References

333

(6)

Plasticity in the Aging Central Nervous System

C. A. Barnes

Introduction

339

(1)

Induction of Long-Term Potentiation at the Schaffer Collateral-CA1 Synapse during Aging

340

(1)

Induction of Long-Term Potentiation at the Perforant Path-Granule Cell Synapse during Aging

341

(1)

Are There Really No Long-Term Potentiation Induction Deficits during Aging?

341

(3)

Are There Long-Term Potentiation Maintenance Deficits during Aging?

344

(1)

Correlations between Spatial Behavior and Hippocampal Plasticity

344

(2)

Pharmacological Modification of Long-Term Potentiation Persistence and Spatial Memory during Aging

346

(1)

Ensemble Recording Methods Used to Assess Behavior and Plasticity Mechanisms during Aging

346

(3)

Conclusion

349

(6)

References

350

(5)

Secondary Epileptogenesis, Kindling, and Intractable Epilepsy: A Reappraisal from the Perspective of Neural Plasticity

Thomas P. Sutula

Introduction

355

(1)

The Mirror Focus and Secondary Epileptogenesis

356

(1)

Does ``Secondary Epileptogenesis'' Occur in People?

357

(1)

Kindling: A Phenomenon of Neural Plasticity Producing Epileptogenesis

358

(1)

Potential Significance of the Mirror Focus, Secondary Epileptogenesis, and kindling for Human Epilepsy

359

(1)

Intractable Temporal Lobe Epilepsy and Hippocampal Sclerosis

359

(2)

Kindling as Model of Temporal Lobe Epilepsy

361

(1)

Cellular and Functional Alterations Observed in Intractable Human Temporal Lobe Epilepsy are Induced by Kindling

362

(12)

Progressive Hippocampal Atrophy in Intractable Temporal Lobe Epilepsy Is Associated with Recurring Seizures

374

(1)

Seizure-Induced Circuit Plasticity and Kindling: Phenomena of Human Epileptogenesis?

375

(1)

Molecular Genetics of Activity-Induced and Seizure-Induced Plasticity: Implications for the Variability and Epidemiology of Epilepsy

376

(1)

Kindling: Seizure-Induced Circuit Plasticity That. Promotes Intractable Epilepsy?

377

(10)

References

379

(8)

Kindling and the Mirror Focus

Dan C. McIntyre

Michael O. Poulter

Introduction

387

(1)

Technical/Procedural Considerations

388

(5)

Discharge Features and Site of Stimulation

393

(4)

Ontogenetic Behavioral Measures

397

(4)

Molecular/Genetic Factors

401

(8)

References

404

(5)

Partial Kindling and Behavioral Pathologies

Robert E. Adamec

Introduction

409

(2)

Studies Involving Cats

411

(14)

Effects of Amygdala Kindling and Low-Frequency Stimulation on Rodent Defensive Response

425

(5)

Conclusions

430

(5)

References

431

(4)

The Mirror Focus and Secondary Epileptogenesis

B. J. Wilder

Introduction

435

(2)

Comparative Studies of Cortical and Subcortical Secondary Epileptogenesis

437

(4)

Summary and Comments

441

(6)

References

444

(3)

Hippocampal Lesions in Epilepsy: A Historical Review

Robert Naquet

Introduction

447

(1)

From the 19th Century to the End of the 1950s

448

(4)

From the 1970s to the Present

452

(6)

Conclusions: From Animal Data to Febrile Convulsions, Hippocampal Lesions, and ``Temporal Lobe Epilepsy'' in Humans

458

(11)

References

460

(9)

Clinical Evidence for Secondary Epileptogenesis

Hans O. Luders

Introduction

469

(1)

Definitions

469

(1)

Stages of Secondary Epileptogenesis

470

(1)

Acute Secondary Epileptogenesis in Humans

471

(2)

Chronic Secondary Epileptogenesis in Humans

473

(4)

Conclusions

477

(4)

References

479

(2)

Epilepsy as a Progressive (or Nonprogressive ``Benign'') Disorder

John A. Wada

Introduction

481

(6)

Phylogenesis and Substrate of Kindling Landmarks

487

(2)

Primary Site Amygdaloid Kindling

489

(4)

Distant Effect of Primary Site Kindling: Secondary Site Amygdaloid Kindling

493

(2)

Durability of Kindled Susceptibility

495

(1)

Discussion

496

(9)

References

500

(5)

Pathophysiological Aspects of Landau--Kleffner Syndrome: From the Active Epileptic Phase to Recovery

Marie-Noelle Metz-Lutz

Pierre Maquet

Anne De Saint Martin

Gabrielle Rudolf

Norma Wioland

Edouard Hirsch

Christian Marescaux

Introduction

505

(2)

Clinical and Pathophysiological Aspects of the Active Epileptic Period

507

(8)

Neuropsychological and Neurophysiological Features after Recovery of Epilepsy

515

(5)

Discussion

520

(4)

Conclusion

524

(3)

References

525

(2)

Local Pathways of Seizure Propagation in Neocortex

Barry W. Connors

David J. Pinto

Albert E. Telfeian

Introduction

527

(1)

Axonal Arbors of the Neocortex

528

(3)

Physiology of Local Neocortical Synapses

531

(1)

Seizure Initiation and the Minimal Epileptogenic Volume

532

(2)

Seizure Propagation: Characteristics

534

(3)

Seizure Propagation: Pathways

537

(4)

Conclusions

541

(6)

References

542

(5)

Multiple Subpial Transection: A Clinical Assessment

C. E. Polkey

Introduction

547

(2)

Experimental Basis of Multiple Subpial Transection

549

(2)

Indications for Multiple Subpial Transection

551

(3)

Technique

554

(3)

Outcome

557

(9)

Discussion

566

(1)

Conclusion

567

(4)

References

567

(4)

The Legacy of Frank Morrell

Jerome Engel, Jr.

Introduction

571

(5)

Brain Plasticity and Mechanisms of Learning

576

(2)

Brain Plasticity and Experimental Epilepsy

578

(3)

Secondary Epileptogenesis

581

(3)

Clinical Studies

584

(3)

The Legacy of Frank Morrell

587

(4)

References

587

(4)

Index

591

Please wait while the item is added to your bag...

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

Summary

Table of Contents

Supplemental Materials

Digital License