Cancer Epidemiology and Prevention

"The definitive reference for budding and experienced cancer epidemiologists alike." -American Journal of Epidemiology

"Practitioners in epidemiology and oncology will find immense value in this." -JAMA

Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans.

Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid to molecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis.

New and timely chapters on environmental and social-epidemiologic factors include:

· The role of social class disparities
· The role of obesity and physical inactivity
· The potential effects of electromagnetic fields and radiofrequency radiation
· The principles of cancer chemoprevention

For both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field -- a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

Michael J. Thun, M.D., M.S., is Vice President Emeritus of Epidemiology and Surveillance Research at the American Cancer Society.

Martha S. Linet, M.D., M.P.H., is Senior Investigator at the National Cancer Institute's Division of Cancer Epidemiology.

James R. Cerhan, M.D., Ph.D., is Professor of Epidemiology, Ralph S. and Beverly Caulkins Professor of Cancer Research, and Chair of the Department of Health Sciences Research, Mayo Clinic College of Medicine.

Christopher A. Haiman, Sc.D., is Professor of Preventive Medicine and Aflac Chair of Cancer Research, Keck School of Medicine, University of Southern California.

David Schottenfeld, M.D., M.Sc., is John G. Searle Professor Emeritus and former Chair of the Department of Epidemiology at the University of Michigan's School of Public Health.

Acknowledgments

Contributors

Preface

1 Introduction

Part I - Basic Concepts

2 Biology of Neoplasia
3 Morphological and Molecular Classification of Human Cancer
4 Genomic Landscape of Cancer - Insights for Epidemiologists
5 Genetic Epidemiology of Cancer
6 Application of Biomarkers in Cancer Epidemiology
7 Causal Inference in Cancer Epidemiology

Part II - The Magnitude of Cancer

8 Patterns of Cancer Incidence, Mortality, and Survival
9 Socioeconomic Disparities in Cancer Incidence and Mortality
10 The Economic Burden of Cancer in the United States

Part III - The Causes of Cancer

11 Tobacco
12 Alcohol and Cancer Risk
13 Ionizing Radiation
14 Ultraviolet Radiation
15 Electromagnetic Fields
16 Occupational Cancer
17 Air Pollution
18 Water Contaminants
19 Diet and Nutrition
20 Obesity and Body Composition
21 Physical Activity, Sedentary Behaviors, and Risk of Cancer
22 Hormones and Cancer
23 Pharmaceutical Drugs Other Than Hormones
24 Infectious Agents
25 Immunologic Factors

Part IV - Cancers by Tissue of Origin

26 Nasopharyngeal Cancer
27 Cancer of the Larynx
28 Lung Cancer
29 Oral Cavity, Oropharynx, Lip, and Salivary Glands
30 Esophageal Cancer
31 Stomach Cancer
32 Cancer of the Pancreas
33 Liver Cancer
34 Biliary Tract Cancer
35 Small Intestine Cancer
36 Cancers of the Colon and Rectum
37 Anal Cancer
38 Leukemias
39 Hodgkin Lymphoma
40 The Non- Hodgkin Lymphomas
41 Multiple Myeloma
42 Bone Cancers
43 Soft Tissue Sarcoma
44 Thyroid Cancer
45 Breast Cancer
46 Ovarian Cancer
47 Endometrial Cancer
48 Cervical Cancer
49 Vulvar and Vaginal Cancers
50 Choriocarcinoma
51 Renal Cancer
52 Bladder Cancer
53 Prostate Cancer
54 Testicular Cancer
55 Penile Cancer
56 Nervous System
57 Melanoma
58 Keratinocyte Cancers
59 Childhood Cancers
60 Multiple Primary Cancers

Part V - Cancer Prevention and Control

61 Framework for Understanding Cancer Prevention
62 Primary Prevention
62.1 Tobacco Control
62.2 Prevention of Obesity and Physical Inactivity
62.3 Prevention of Infection-Related Cancers
62.4 Protection from Ultraviolet Radiation
62.5 Preventive Therapy
62.6 Regulation
63 Cancer Screening