Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

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ISBN: 9780444515001 | 0444515003
Cover: Hardcover
Copyright: 7/6/2005

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Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Contributors

Preface

Section I. Caveolae Organization and Role in Lipid Cholesterol Metabolism

Lipid Rafts and Caveolae Organization

Friedhelm Schroeder

Barbara P. Atshaves

Adalberto M. Gallegos

Avery L. McIntosh

J. C. Steve Liu

Ann B. Kier

Huan Huang

Judith M. Ball

Introduction

(3)

A Non-detergent Method of Simultaneously Isolating Caveolae/Lipid Rafts and Non-raft Domains

(3)

Lipid Composition of Lipid Rafts/Caveolae and Non-raft Domains

(2)

Fluidity and Structure of Lipid Rafts/Caveolae and Non-rafts

(2)

Cholesterol Organization in Lipid Rafts/Caveolae and Non-rafts

(3)

Sterol Carrier Protein-2 Selectively Modulates Cholesterol Dynamics in Lipid Rafts/Caveolae

(2)

Multiphoton Imaging of Sterol Structure and Distribution in Lipid Rafts/Caveolae of Living Cells

(4)

Caveolin Interacts with Select Lipids in Caveolae

(1)

Peptide-Protein Interactions with Model Membrane Lipid Rafts: SCP-2

(2)

Peptide-Protein Interactions with Model Membrane Lipid Rafts: Cholera Toxin and Rotavirus NSP4, an Enterotoxin

(2)

Prospectus

(11)

References

(10)

Caveolae and the Regulation of Cellular Cholesterol Homeostasis

William V. Everson

Eric J. Smart

Introduction

(1)

Organization

(1)

Endothelial Transcytosis

(1)

Proteins Associated with Caveolae and Lipid Rafts Confer Stability

(1)

Annexin II Is a Prominent Protein in Caveolae/Lipid Rafts and Lipid Raft Vesicles

(2)

Focal Adhesions Are Specialized Caveolae

(1)

Cholesterol and Caveolin Internalization

(1)

Caveolin Chaperone Complexes, Cholesterol Trafficking, and Caveolae Organization

(2)

Caveolin Acylation and Chaperone Complex-Mediated Cholesterol Trafficking

(1)

Cholesterol Transport in Specialized Cells

(1)

Caveolin Vesicles Connect the Surface to a Network of Intracellular Tubules and Vesicles

(1)

Annexin II and Lipid Raft Endocytosis and Exocytosis

(2)

PM Cholesterol Content Alters Caveola Vesicle Internalization

(1)

Microfilaments and Microtubules Regulate Distinct Steps in the Caveolae Trafficking

(1)

Uptake of SV40 and Trafficking to the Caveosome and Smooth ER

(1)

Autocrine Motility Factor Trafficks via Caveola Vesicles to Two Regions of the ER

(1)

Orientation of Cholesterol and Proteins in the Lipid Raft Bilayer

(1)

Cholesterol Trafficking and Caveolae Physiology: eNOS Signaling in Vasodilation

(1)

``Liquid Ordered Domain'' Fluidity and eNOS Signaling

(1)

Conclusion

(7)

References

(6)

Section II. Caveolae Organization and the Regulation of Endocytosis

The Caveolae Internalization Machinery

L. S. Orlichenko

M. A. McNiven

Introduction: Caveolae as Endocytic Organelles

(1)

Caveolin Recruitment to the Plasma Membrane

(1)

Caveolar Scission

(11)

Perspectives

(7)

References

(7)

Lipid Raft-Mediated Entry of Bacteria into Host Cells

Matthew J. Duncan

Soman N. Abraham

Introduction

(1)

Lipid Raft-Mediated Entry of Bacteria into Host Cells

(5)

Conclusion

(6)

References

(6)

Section III. Examples of the Role of Caveolins in Cell Signalling

The Caveolin Interaction with Endothelial Nitric Oxide Synthase (eNOS)

Olivier Feron

Introduction

(1)

The Caveolin-eNOS Interactions

(2)

Caveolin, eNOS, and Cholesterol

(3)

Caveolin, eNOS, and Angiogenesis

(3)

Caveolin, eNOS, and Endothelial Permeability

100

(3)

Caveolin, eNOS, and Vasodilation

103

(1)

Conclusion

104

(5)

References

104

(5)

Caveolae and Estrogen Receptor Signaling

Philip W. Shaul

Ken L. Chambliss

Introduction

109

(1)

Estrogen and eNOS Activation

110

(1)

Localization of eNOS Activation by E2 to Plasma Membrane

110

(2)

Characterization of Plasma Membrane ER in Endothelial Cells

112

(2)

Localization of ERα-eNOS Coupling to Caveolae

114

(1)

Comparable Role of ERβ in Endothelial Caveolae

114

(3)

G-proteins and ER Coupling to eNOS

117

(3)

Additional Intricacies about ER in Caveolae

120

(1)

Summary and Future Directions

121

(4)

References

122

(3)

eNOS Regulation by Sphingosine 1-Phosphate and Caveolin

Junsuke Igarashi

eNOS as a Key Vascular Enzyme

125

(1)

eNOS Acylation, Targeting to Caveolae, and Regulation by Caveolin

126

(1)

Sphingosine 1-Phosphate and Regulation of Vascular Endothelial Cells

127

(1)

eNOS Activation by SIP and Endothelial Signaling

128

(1)

Roles of Caveolae for eNOS Regulation by SIP

129

(2)

eNOS Regulation and Receptor Cross-talk of SIP Signaling

131

(1)

Implications for Vascular Physiology

132

(1)

Possibilities in Nonendothelial Cells

133

(2)

Concluding Remarks

135

(7)

References

135

(7)

Insulin Signaling and Caveolae

Peter Stralfors

Insulin Action

142

(2)

Caveolae and the Adipocyte

144

(3)

Insulin Signaling in Caveolae

147

(5)

Mechanisms for Targeting the Insulin Receptor to Caveolae

152

(3)

Adipose Tissue and Insulin Signaling in Caveolin-1-Deficient Animals

155

(2)

Insulin-Stimulated Glucose Uptake in Caveolae

157

(4)

Insulin Signaling and Caveolae in Other Tissues

161

(1)

Conclusion

162

(12)

References

162

(12)

Section IV. Caveolae and Pathologies

Caveolin-3, Caveolae, and Hereditary Muscle Diseases

Matthias Vorgerd

Caveolin-3 in Muscular Dystrophies

174

(2)

Rippling Muscle Disease (RMD)

176

(3)

Distal Myopathy

179

(1)

HyperCKemia

179

(1)

Cardiomyopathy

179

(1)

Intrafamilial Clinical Heterogeneity in CAV3 Families

180

(1)

Pathogenesis of CAV3 Deficiency

180

(3)

Summary

183

(5)

References

184

(4)

Caveolae and Caveolins in the Vascular System: Functional Roles in Endothelia, Macrophages, and Smooth Muscle Cells

Ghada S. Hassan

Michael P. Lisanti

Philippe G. Frank

Caveolae and Caveolins in Endothelial Celis

188

(10)

Caveolin-1 in Macrophages

198

(1)

Caveolae and Caveolins in Vascular Smooth Muscle Cells

199

(3)

Conclusions

202

(9)

References

204

(7)

Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers

Jean-Francois Jasmin

Philippe G. Frank

Michael P. Lisanti

Caveolin Proteins and the Cardiopulmonary System

211

(16)

Conclusions

227

(8)

References

228

(7)

Abbreviations and Acronyms

235

(2)

Index

237

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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

Summary

Table of Contents

Supplemental Materials

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