The Cell

The Cell: A Molecular Approach is an easily understood and concise introduction to the molecular biology of cells, ideally suited in length and complexity for undergraduate-level courses. This unique book has been crafted to meet the need of today's students and their teachers by combining the readability and cohesiveness of a single-authored text with comprehensive and up-to-date science.

Unlike other larger books where only a small fraction of the content can be sampled or understood, The Cell's language and writing are so efficient and manageable that all the information in the book can be covered in a single semester, providing a good foundation in this subject.

The Cell presents a good balance of topics in a clean and concise manner and combines a lucid sketch of the history of molecular genetics with a thorough description of the techniques of modern molecular biology. This new text provides both the necessary fundamentals of this subject as well as the more advanced concepts but without getting lost in too many details. A text extensively reviewed by

Preface	p. xv
Organization and Features of The Cell	p. xvii
Acknowledgments	p. xix
Reviewers	p. xxi
Supplements to Accompany The Cell	p. xxiii
Introduction
An Overview of Cells and Cell Research	p. 3
The Origin and Evolution of Cells	p. 4
Cells as Experimental Models	p. 15
Tools of Cell Biology	p. 20
The Chemistry of Cells	p. 41
The Molecular Composition of Cells	p. 41
The Central Role of Enzymes as Biological Catalysts	p. 56
Metabolic Energy	p. 63
The Biosynthesis of Cell Constituents	p. 73
Cell Membranes	p. 79
Fundamentals of Molecular Biology	p. 89
Heredity, Genes, and DNA	p. 89
Expression of Genetic Information	p. 97
Recombinant DNA	p. 104
Detection of Nucleic Acids and Proteins	p. 116
Gene Function in Eukaryotes	p. 122
The Flow of Genetic Information
The Organization of Cellular Genomes	p. 137
The Complexity of Eukaryotic Genomes	p. 137
Chromosomes and Chromatin	p. 146
The Sequences of Complete Genomes	p. 154
The Human Genome	p. 162
Replication, Maintenance, and Rearrangements of Genomic DNA	p. 177
DNA Replication	p. 177
DNA Repair	p. 192
Recombination Between Homologous DNA Sequences	p. 201
DNA Rearrangements	p. 208
RNA Synthesis and Processing	p. 227
Transcription in Prokaryotes	p. 227
Eukaryotic RNA Polymerases and General Transcription Factors	p. 236
Regulation of Transcription in Eukaryotes	p. 241
RNA Processing and Turnover	p. 257
Protein Synthesis, Processing, and Regulation	p. 273
Translation of mRNA	p. 273
Protein Folding and Processing	p. 290
Regulation of Protein Function	p. 301
Protein Degradation	p. 305
Cell Structure and Function
The Nucleus	p. 315
The Nuclear Envelope and Traffic Between the Nucleus and Cytoplasm	p. 315
Internal Organization of the Nucleus	p. 327
The Nucleolus	p. 332
The Nucleus During Mitosis	p. 337
Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes	p. 347
The Endoplasmic Reticulum	p. 347
The Golgi Apparatus	p. 364
The Mechanism of Vesicular Transport	p. 372
Lysosomes	p. 378
Bioenergetics and Metabolism: Mitochondria, Chloroplasts, and Peroxisomes	p. 387
Mitochondria	p. 387
The Mechanism of Oxidative Phosphorylation	p. 396
Chloroplasts and other Plastids	p. 402
Photosynthesis	p. 409
Peroxisomes	p. 413
The Cytoskeleton and Cell Movement	p. 421
Structure and Organization of Actin Filaments	p. 421
Actin, Myosin, and Cell Movement	p. 432
Intermediate Filaments	p. 440
Microtubules	p. 446
Microtubule Motors and Movements	p. 452
The Cell Surface	p. 467
Structure of the Plasma Membrane	p. 467
Transport of Small Molecules	p. 476
Endocytosis	p. 492
Cell Walls and the Extracellular Matrix	p. 500
Cell-Cell Interactions	p. 510
Cell Regulation
Cell Signaling	p. 523
Signaling Molecules and Their Receptors	p. 523
Functions of Cell Surface Receptors	p. 532
Pathways of Intracellular Signal Transduction	p. 539
Signal Transduction and the Cytoskeleton	p. 553
Signaling in Development and Differentiation	p. 556
Regulation of Programmed Cell Death	p. 560
The Cell Cycle	p. 571
The Eukaryotic Cell Cycle	p. 571
Regulators of Cell Cycle Progression	p. 578
The Events of M Phase	p. 587
Meiosis and Fertilization	p. 594
Cell Proliferation in Development and Differentiation	p. 599
Cancer	p. 609
The Development and Causes of Cancer	p. 609
Tumor Viruses	p. 618
Oncogenes	p. 622
Tumor Suppressor Genes	p. 635
Applications of Molecular Biology to Cancer Prevention and Treatment	p. 642
Answers to Questions	p. 651
Glossary	p. 657
Index	p. 671
Table of Contents provided by Syndetics. All Rights Reserved.

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