Cellular Aspects of HIV Infection

Cellular Aspects of HIV Infection provides a highly readable, detailed overview of the state of the art in modern HIV research at the cellular level. This volume brings together renowned experts who have provided concise, synthetic treatments of the biology of HIV infection. It presents these descriptions and analyses with particular attention to the techniques of flow cytometry that have allowed us to not only observe the course of HIV infection and the immune system's response to it, but have also increased our ability to treat patients and understand their response to therapy. The book is divided into five sections covering molecules and cells, pathophysiological processes, technologies, and organisms. A perspective on future therapies concludes the book. Each chapter offers an intelligent, concise synthesis of the topic, highlighting the biological principles and technologies involved in the study of HIV infection. Cellular Aspects of HIV Infection is an indispensable, up-to-date guide for immunologists, virologists, clinicians, and researchers.

Andrea Cossarizza is currently Professor of Immunology at the Modena and Reggio Emilia university School of Medicine. He received his MD from the University of Padua, and PhD from the Universities of Modena and Bologna. His professional experience includes: 1986-1988 Fellow, Chair of Immunology, Modena University; 1991-pres Responsible, Flow Cytometry Unit, Chair Immunol.; 1996-pres Responsible, Research Unit on HIV, Department Infect. Dis., Modena; Chairman session "Cell Proliferation", I World Congress for Electricity and Magnetism in Biology and Medicine, Orlando, 1992; Chairman session "Neuroimmunoendocrinology", 39th National Congress of the Italian Society of Geriatrics, Florence, 1994; Member of: Int. Soc. for Analytical Cytology, Ital. Immunol. Society; Referee of Int. Human Frontier Science Program Organization (HFSPO) 1994-1998; Referee for AIDS, FEBS Lett., Exp. Cell Res., Immunology Lett., Aging - Clin. Exp. Res, J. Endocrinol. Invest.
Guest Editor of an issue of International Reviews of Immunology.
He has published aproximately 140 papers in peer-reviewed journals and edited 3 books.

Preface

ix

Contributors

xi

Part I MOLECULES

1

(66)

HIV and Molecular Biology of the Virus-Host Interplay

3

(10)

Massimo Clementi

Telomere Length, CD28- T Cells, and HIV Disease Pathogenesis

13

(20)

Rita B. Effros

Immune Dysregulation and T-Cell Activation Antigens in HIV Infection

33

(20)

Mara Biasin

Fulvia Colombo

Stefania Piconi

Mario Clerici

Quantification of HIV/SIV Coreceptor Expression

53

(14)

Benhur Lee

Robert W. Doms

Part II CELLS

67

(182)

B Cells in the Line of Sight of HIV-1

69

(34)

Yolande Richard

Eric A. Lefevre

Roman Krzysiek

Christophe Legendre

Dominique Dormont

Pierre Galanaud

Gabriel Gras

Cytotoxic T-Cell (CTL) Function in HIV Infection

103

(24)

M. L. Garba

J. A. Frelinger

Analysis of the α/β T-Cell Receptor Repertoire in HIV Infection

127

(20)

Hugo Soudenys

Gamma-Delta (γδ) T Cells and HIV-1 Infection

147

(36)

Roxana E. Rojas

W. Henry Boom

Natural Killer Cells in HIV Infection and Role in the Pathogenesis of AIDS

183

(24)

Benjamin Bonavida

Alveolar Macrophages

207

(22)

Jianmin Zhang

Henry Koziel

Dendritic Cells Ferry HIV-1 from Periphery into Lymphoid Tissues

229

(20)

Teunis B. H. Geijtenbeek

Yvette van Kooyk

Part III PROCESSES

249

(64)

Homeostasis and Restoration of the Immune System in HAART-Treated HIV-Infected Patients: Implications of Apoptosis

251

(18)

Marie-Lise Gougeon

Herve LeCoeur

Luzia Maria de Oliveira Pinto

Eric Ledru

Mitochondria Functionality During HIV Infection

269

(24)

Andrea Cossarizza

Marcello Pinti

Milena Nasi

Maria Garcia Fernandez

Laura Moretti

Cristina Mussini

Leonarda Troiano

Multiple Roles of Cytokines in HIV Infection, Replication, and Therapy

293

(20)

Massimo Alfano

Guido Poli

Part IV TECHNOLOGIES

313

(70)

The Use of Peptide/MHC Tetramers to Visualize, Track, and Characterize Class I-Restricted Anti-HIV T-Cell Response

315

(18)

Clive M. Gray

Thomas C. Merigan

Tagging of HIV with Green Fluorescent Protein

333

(18)

Nadya I. Tarasova

Flow Cytometric Analysis of Cells from Persons with HIV-1 Disease by Enzymatic Amplification Staining

351

(20)

David Kaplan

Antigen-Specific Cytokine Responses in HIV Disease

371

(12)

Vernon C. Maino

Holden T. Maecker

Louis J. Picker

Part V ORGANISMS

383

(56)

Chimeric Models of SCID Mice Transplanted with Human Cells: The Hu-PBL-SCID Mouse and Its Use in AIDS Research

385

(14)

S. M. Santini

C. Lapenta

M. Logozzi

S. Parlato

M. Spada

T. Di Pucchio

S. Fais

F. Belardelli

Immune Reconstitution of the CD4 T-Cell Compartment in HIV Infection

399

(24)

Guislaine Carcelain

Taisheng Li

Marc Renaud

Patrice Debre

Brigitte Autran

New Perspectives in Antiretroviral Therapy of HIV Infection

423

(16)

Stefano Vella

Index

439

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Cellular Aspects of HIV Infection

Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Cellular Aspects of HIV Infection

Summary

Author Biography

Table of Contents

Supplemental Materials

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