The Centrosome in Cell Replication and Early Development

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ISBN: 9780121531492 | 012153149X
Cover: Hardcover
Copyright: 9/11/2000

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Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of Current Topics in Developmental Biology will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed. Key Features * Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome * Heavily illustrated, with many color figures * Chapters written by international leaders in the field

Contributors

Preface

xix

The Centrosome and Parthenogenesis

Thomas Kuntziger

Michel Bornens

Introduction

(1)

Toward a Functional Description of the Centrosome

(10)

The Centrosome Organelle versus Self-Assembled Centers

(1)

Centrosome Reproduction and the Parthenogenetic Activity of the Centrosome

(5)

Conclusion

(9)

References

(8)

γ-Tubulin

Berl R. Oakley

Centrosomes and Microtubule Nucleation

(3)

γ-Tubulin and the Tubulin Superfamily of Proteins

(3)

Distribution of γ-Tubulin in Cells

(6)

Studies of γ-Tubulin Function

(6)

γ-Tubulin and Microtubule Assembly: Current Knowledge and Unanswered Questions

(4)

Concluding Remarks

(6)

References

(6)

γ-Tubulin Complexes and Their Role in Microtubule Nucleation

Ruwanthi N. Gunawardane

Sofia B. Lizarraga

Christiane Wiese

Andrew Wilde

Yixian Zheng

Introduction

(2)

Biochemical and Structural Studies of γTuRC and γTuSC

(7)

Evidence That γTuRC Is the Major Microtubule Nucleator at the Centrosome

(1)

The Mechanism of Microtubule Nucleation

(4)

Concluding Remarks

(6)

References

(5)

γ-Tubulin of Budding Yeast

Jackie Vogel

Michael Snyder

Introduction

(5)

Tubulins of Yeast

(8)

Interactions between Tubulins

(3)

The γ-Tubulin Complex in Yeast

(4)

Future Directions

(10)

References

(8)

The Spindle Pole Body of Saccharomyces cerevisiae: Architecture and Assembly of the Core Components

Susan E. Francis

Trisha N. Davis

Introduction

105

(1)

SPB Duplication and Assembly of the Mitotic Spindle

106

(1)

Structure of the SPB

107

(2)

SPB Core Components

109

(13)

Assembly of the Core SPB Components

122

(1)

Transcriptional Regulation of Core SPB Components

123

(1)

Homologs of Spindle Pole Components in Other Organisms

124

(1)

Future Directions

125

(8)

References

128

(5)

The Microtubule Organizing Centers of Schizosaccharomyces pombe

Iain M. Hagan

Janni Petersen

Introduction

133

(3)

Cytoplasmic Microtubule Organizing Centers

136

(2)

The Spindle Pole Body

138

(11)

Molecular Characterization of SPB Components

149

(4)

Perspectives

153

(8)

References

154

(7)

Comparative Structural, Molecular, and Functional Aspects of the Dictyostelium discoideum Centrosome

Ralph Graf

Nicole Brusis

Christine Daunderer

Ursula Euteneuer

Andrea Hestermann

Manfred Schliwa

Masahiro Ueda

Introduction

161

(2)

Comparative Morphology of the Dictyostelium Centrosome

163

(4)

Comparative Analysis of Dictyostelium Centrosome Duplication

167

(4)

Comparative Molecular Biology of the Dictyostelium Centrosome

171

(8)

Conclusions

179

(8)

References

179

(8)

Are There Nucleic Acids in the Centrosome?

Wallace F. Marshall

Joel L. Rosenbaum

Introduction

187

(1)

Do Centrioles or Centrosomes Contain DNA?

188

(9)

Do Centrosomes Contain RNA?

197

(4)

Conclusions

201

(6)

References

202

(5)

Basal Bodies and Centrioles: Their Function and Structure

Andrea M. Preble

Thomas M. Giddings, Jr.

Susan K. Dutcher

Introduction to Centrioles and Basal Bodies

207

(5)

The Structure of Centrioles and Basal Bodies

212

(9)

The Function of Basal Bodies and Centrioles as Revealed by Mutational Analysis

221

(5)

Basal Body/Centriole Replication

226

(9)

References

228

(7)

Centriole Duplication and Maturation in Animal Cells

B. M. H. Lange

A. J. Faragher

P. March

K. Gull

Overview

235

(1)

Centriole Lineage Patterns

236

(1)

Structural Features of Centriole Maturation and Duplication

236

(3)

Centriolar Duplication, Maturation, and the Cell Cycle

239

(3)

Centriolar Maturation and Centriolar Function

242

(2)

Ciliogenesis and Cell Cycle

244

(1)

Future Developments and Directions

245

(6)

References

245

(6)

Centrosome Replication in Somatic Cells: The Significance of the G1 Phase

Ron Balczon

Introduction

251

(1)

The Cell Cycle in Somatic Mammalian Cells

251

(1)

Electron Microscopic Descriptions of Centrosome Doubling, and the Cellular Events of Centrosome Replication

252

(3)

Spindle Pole Body Doubling in Yeast Cells

255

(5)

Events in G1 That Trigger Centrosome Replication in Somatic Mammalian Cells

260

(3)

Summary

263

(4)

References

264

(3)

The Coordination of Centrosome Reproduction with Nuclear Events during the Cell Cycle

Greenfield Sluder

Edward H. Hinchcliffe

Introduction

267

(2)

The Events of Centrosome Reproduction

269

(2)

Controls for Centrosome Reproduction

271

(5)

Coordination of Centrosome Reproduction with Nuclear Events in the Cell Cycle

276

(15)

References

286

(5)

Regulating Centrosomes by Protein Phosphorylation

Andrew M. Fry

Thibault Mayor

Erich A. Nigg

Introduction

291

(1)

Protein Phosphorylation: A Major Theme in Cell Cycle Control

292

(2)

Centrosome and Spindle Pole Body Dynamics through the Cell Cycle

294

(1)

In Control of Centrosome Duplication

295

(3)

Regulating Microtubule Nucleation

298

(2)

Establishing a Bipolar Mitotic Spindle

300

(5)

Creating the Zygotic Centrosome

305

(1)

Loss of Phosphorylation Control: Cancer Implications

306

(2)

Perspectives: Into the Next Millennium

308

(5)

References

309

(4)

The Role of the Centrosome in the Development of Malignant Tumors

Wilma L. Lingle

Jeffrey L. Salisbury

Introduction

313

(3)

Centrosome Defects and Abnormal Mitoses in Cancer

316

(1)

Amplified Centrosomes and Aneuploidy

317

(2)

Excess Pericentriolar Material Is Associated with High Frequency of Abnormal Mitoses

319

(1)

Centrosome-Associated Kinases and Cancer

320

(1)

Tumor Suppressor Proteins and the Centrosome

321

(3)

Maintenance of Cell and Tissue Polarity Minimizes Tumor Aggression in Model Systems

324

(1)

Conclusions

325

(6)

References

326

(5)

The Centrosome-Associated Aurora/Ipl-like Kinase Family

T. M. Goepfert

B. R. Brinkley

Introduction

331

(2)

The Aurora and Ipl-like Family: Structure, Regulation, and Substrates

333

(6)

Summary

339

(4)

References

340

(3)

Centrosome Reduction during Mammalian Spermiogenesis

G. Manandhar

C. Simerly

G. Schatten

Introduction

343

(2)

Overview of Mammalian Spermiogenesis

345

(2)

Stages of Centrosome Reduction during Spermiogenesis

347

(11)

Conclusions

358

(7)

References

358

(7)

The Centrosome of the Early C. elegans Embryo: Inheritance, Assembly, Replication, and Developmental Roles

Kevin F. O'Connell

Why C. elegans?

365

(2)

Origin and Replication of the Zygotic Centrosomes

367

(7)

The Central Role of the Centrosome-Pronucleus Complex in Specifying AP Polarity

374

(4)

Nuclear Positioning

378

(2)

Concluding Remarks

380

(5)

References

381

(4)

The Centrosome in Drosophila Oocyte Development

Timothy L. Megraw

Thomas C. Kaufman

Introduction

385

(2)

The Germarium: Centrosomes Are Anchored to Achieve Polarized Cell Divisions

387

(4)

The Oocyte MTOC

391

(5)

Meiosis

396

(4)

Summary

400

(10)

References

402

(8)

The Centrosome in Early Drosophila Embryogenesis

W. F. Rothwell

W. Sullivan

Introduction

410

(2)

Ultrastructure

412

(3)

Composition

415

(6)

Duplication and Separation

421

(6)

Fertilization and the First Mitotic Division

427

(3)

Precortical Divisions

430

(2)

Cortical Divisions

432

(17)

References

440

(9)

Centrosome Maturation

Robert E. Palazzo

Jacalyn M. Vogel

Bradley J. Schnackenberg

Dawn R. Hull

Xingyong Wu

Introduction

449

(2)

Centrosome Maturation

451

(2)

Centrosome Structure and Microtubule Nucleation Potential

453

(4)

The Role of the Centriole

457

(1)

The Procentrosome

458

(2)

Paternal versus Maternal Centrosomes

460

(2)

Summary

462

(9)

References

463

(8)

Index

471

(14)

Contents of Previous Volumes

485

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The Centrosome in Cell Replication and Early Development

Summary

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Summary

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