Chemical and Functional Genomic Approaches to

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

Sheng Ding is an Associate Professor in the Departments of Chemistry and Cell Biology at the Scripps Research Institute. He is a member of the American Chemical Society, American Society for Cell Biology, and the International Society for Stem Cell Research. Dr. Ding is the author or coauthor of thirty-four papers and seventeen reviews and book chapters, in addition to being coholder of thirteen?patents.

Contributors	p. vii
Embryonic Stem Cells	p. 1
Adult Stem Cells	p. 27
Genomewide Expression Analysis Technologies	p. 59
Genomic cDNA and RNAi Functional Profiling and Its Potential Application to the Study of Mammalian Stem Cells	p. 83
Chemical Technologies: Probing Biology with Small Molecules	p. 109
Protein Characterization by Biological Mass Spectrometry	p. 145
Large-Scale Genomic Analysis of Stem Cell Populations	p. 169
Exploring Stem Cell Biology with Small Molecules and Functional Genomics	p. 187
Regeneration Screens in Model Organisms	p. 207
Proteomics in Stem Cells	p. 223
Index	p. 243
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Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

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