Chiral Separations and Stereochemical Elucidation Fundamentals, Methods, and Applications

An expert resource for chemists using stereochemical analysis methods

In Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications, a team of distinguished researchers delivers a robust and authoritative discussion of the theoretical fundamentals of chiral separation, the most commonly used chiral selectors, and stereochemical elucidation methods. The book offers expert discussions of a variety of chiral separation methods by gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), and liquid chromatography (LC).

The authors also describe several methods for stereochemical elucidation, including X-ray crystallography, nuclear magnetic resonance spectroscopy, and chiroptical methods. The explored material is ideal for practicing chemists seeking a resource to help them guide method development and optimization or to explain quality control-complements during target compound production.

Readers will also find:

• A thorough introduction to the most important advances and applications in LC, GC, CE, SFC, and preparative chromatography
• Comprehensive explorations of the role of 2D-LC for chiral separation methods development and applications
• Practical discussions of the design, mechanisms, and applications of the most commonly used chiral selectors
• Fulsome treatments of the theoretical backgrounds, advantages, limitations, and applications of stereochemical elucidation methods

Perfect for academic and industrial chemists specially in organic, analytical chemistry and pharmaceutical analysis. Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications will also benefit biochemists, environmental analysts, forensic and medicinal chemists as well as natural product chemists and those involved with stereochemistry or structural elucidation.

Quezia B. Cass, PhD, is a full Professor in the Chemistry Department of Federal University of São Carlos in Brazil.

Maria Elizabeth Tiritan, PhD, is an Assistant Professor of Organic Chemistry at the Faculty of Pharmacy of Porto University in Portugal.

Juliana Cristina Barreiro, PhD, is a researcher at Chemistry Institute of São Carlos, University of São Paulo, in São Carlos, University of São Paulo , Brazil.

João Marcos Batista Jr., PhD, is an Assistant Professor of Chemistry at the Federal University of São Paulo - UNIFESP, in São José dos Campos, Brazil.

List of Contributors

               Preface

Chapter 1            Chiral separation by LC

Chapter 2            Chiral separation by GC

Chapter 3            Chiral separation by supercritical fluid chromatography

Chapter 4            Chiral separation by capillary electrophoresis and capillary electrophoresis – mass spectrometry: fundamentals, recent developments and applications

Chapter 5            Chiral Separations at Semi and Preparative Scale

Chapter 6            Polysaccharides

Chapter 7            Macrocyclic antibiotics and Cyclofructans

Chapter 8            Cyclodextrins

Chapter 9            Pirkle type

Chapter 10          Proteins

Chapter 11          Chiral stationary phases derived from cinchona alkaloids

Chapter 12          X-ray crystallography for stereochemical elucidation

Chapter 13          NMR for stereochemical elucidation

Chapter 14          Absolute configuration from chiroptical spectroscopy

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