Chromosome Segregation & Structure Cold Spring Harbor Symposium on Quantitative Biology, Volume LXXXII

Contents

Symposium Participants
Foreword

Chromatin, Histones, And Instability
\'1d
Shaping Chromatin in the Nucleus: The Bricks and the Architects
David Sitbon, Katrina Podsypanina, Tejas Yadav, and Genevieve Almouzni\'1d
On the Importance of Satellite Sequence Repression for Genome Stability
Peter Zeller and Susan M. Gasser\'1d
Structure and Epigenetic Regulation of Chromatin Fibers
Ping Chen and Guohong Li\'1d

Chromosome Biology and Genome Architecture
\'1d
The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure
Sarah C. Hsu and Gerd A. Blobel\'1d
Emerging Evidence of Chromosome Folding by Loop Extrusion
Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, and Leonid A. Mirny\'1d
SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches
Prabhakar R. Gudla, Koh Nakayama, Gianluca Pegoraro, and Tom Misteli\'1d

Centromeres and Kinetochores
\'1d
Remarkable Evolutionary Plasticity of Centromeric Chromatin
Steven Henikoff, Jitendra Thakur, Sivakanthan Kasinathan, and Paul B. Talbert\'1d
Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation
Simon Jenni, Yoana N. Dimitrova, Roberto Valverde, Stephen M. Hinshaw, and Stephen C. Harrison\'1d
Aurora A Kinase Function at Kinetochores
Jennifer DeLuca\'1d
RotoStep: A Chromosome Dynamics Simulator Reveals Mechanisms of Loop Extrusion
Josh Lawrimore, Brandon Friedman, Ayush Doshi, and Kerry Bloom\'1d
Taming the Beast: Control of APC/CCdc20-Dependent Destruction
Pablo Lara-Gonzalez, Taekyung Kim, and Arshad Desai\'1d

Organizing Chromosomes during Segregation
\'1d
Noncanonical Biogenesis of Centrioles and Basal Bodies
Catarina Nabais, Sónia Gomes Pereira, and Mónica Bettencourt-Dias\'1d
Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer
Erich A. Nigg, Dominik Schnerch, and Olivier Ganier\'1d
The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules
Jennifer T. Wang and Tim Stearns\'1d
Mitotic Chromosome Assembly In Vitro: Functional Cross Talk between Nucleosomes and Condensins
Keishi Shintomi and Tatsuya Hirano\'1d

Mitosis and Cell Cycle
\'1d
Spindle-to-Cortex Communication in Cleaving Frog Eggs
Timothy J. Mitchison and Christine M. Field\'1d
Nucleosome-Dependent Pathways That Control Mitotic Progression
Hironori Funabiki, Christopher Jenness, and Christian Zierhut\'1d
Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
Kata Sarlós, Andreas Biebricher, Erwin J.G. Petermann, Gijs J.L. Wuite, and Ian D. Hickson\'1d
Low-Level, Global Transcription during Mitosis and Dynamic Gene Reactivation during Mitotic Exit
Katherine C. Palozola, Hong Liu, Dario Nicetto, and Kenneth S. Zaret\'1d
Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates
Stephen C. West and Ying Wai Chan\'1d

Meiosis
\'1d
Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals
So I. Nagaoka and Mitinori Saitou\'1d
Regulation of Crossover Frequency and Distribution during Meiotic Recombination
Takamune T. Saito and Monica P. Colaiácovo\'1d
Emerging Roles of the Ubiquitin-Proteasome System in the Regulation of Meiotic Recombination
Neil Hunter\'1d
Cellular and Molecular Mechanisms of Centromere Drive
Michael A. Lampson and Ben E. Black\'1d
Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I
Seira Miyazaki, Jihye Kim, Takeshi Sakuno, and Yoshinori Watanabe\'1d

Germ Cells, Imprinting, Gene Dosage, and Regulation
\'1d
Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease and Evolution
Rafael Galupa and Edith Heard\'1d
Dynamic Control of Chromosome Topology and Gene Expression by a Chromatin Modification
Qian Bian, Erika C. Anderson, Katjusa Brejc, and Barbara J. Meyer\'1d
Polytene Chromosome Structure and Somatic Genome Instability
Allan C. Spradling\'1d

Heterochromatin, Errors, And Damage
\'1d
Symmetry from Asymmetry or Asymmetry from Symmetry?
Elizabeth W. Kahney, Rajesh Ranjan, Ryan J. Gleason, and Xin Chen\'1d
Function of Junk: Pericentromeric Satellite DNA in Chromosome Maintenance
Madhav Jagannathan and Yukiko M. Yamashita\'1d
Homologous Recombination and Replication Fork Protection: BRCA2 and More!
Weiran Feng and Maria Jasin\'1d
Fork Protection and Therapy Resistance in Hereditary Breast Cancer
Sharon B. Cantor and Jennifer A. Calvo\'1d

Summary
David Pellman

Dorcas Cummings Lecture
David Page

Conversations at the Symposium
\'1d
Marisa Bartolomei
\'1d
Mónica Bettencourt-Dias
\'1d
Kerry Bloom
\'1d
Iain Cheeseman
\'1d
Monica P. Colaiácovo
\'1d
Bernard de Massy
\'1d
Arshad Desai
\'1d
Daniel Durocher
\'1d
Steve Henikoff
\'1d
Martin Hetzer
\'1d
Ian Hickson
\'1d
Maria Jasin
\'1d
Leonid Mirny
\'1d
Timothy Mitchison
\'1d
Tim Stearns
\'1d
Aaron Straight
\'1d
Yukiko Yamashita
\'1d
Author Index
Subject Index