Chronic Obstructive Pulmonary Disease

The only international clinical textbook for COPD - one of the top 5 causes of death and disability worldwide The only COPD textbook to include the latest national and international guidelines and the newer therapeutic agents in COPD treatment International team of contributors covers all aspects of COPD - from physiology and epidemiology to diagnosis and treatment Everything the busy physician needs to understand, diagnose and treat the COPD patient:- Structure and physiology of the respiratory system - Clinical considerations and allied conditions - Therapy (including current and developing treatments) - Diagnostic tests used in daily practice

Professor Robert Stockley is the Head of Department at the Queen Elizabeth Hospital in Birmingham. He is a respiratory physician working in the field of chronic obstructive pulmonary disease.

Professor Stephen Rennard is Larson Professor of Medicine in the Pulmonary and Critical Care Medicine Section of the Department of Internal Medicine at the University of Nebraska Medical Center in Omaha, Nebraska. He is the North American Editor for Respiratory Medicine and Associate Editor for COPD for the European Respiratory Journal.

Professor Klaus Rabe is Professor of Pulmonary Medicine and Chairman for the Department of Pneumology in the University of Leiden. He has been active in various fields of respiratory medicine in Europe and was the first European Associate Editor of the American Journal of Respiratory and Critical Care Medicine. He is co-Chief Editor of the European Respiratory Journal.

Dr Bart Celli is Professor of Medicine at Tufts University in Boston and Chief of the Division of Pulmonary and Critical Care Medicine at the St Elizabeth's Medical Center at Tufts University School of Medicine. He is the author of more than 120 publications on COPD and is the co-editor of Baum's Textbook of Pulmonary Diseases and Hodgkin's Textbook in Pulmonary Rehabilitation.

Contributors
Preface
Physiology
Structure-Function Relationships: the Pathophysiology of Airflow Obstruction
The Physiology of Breathlessness
The Physiology of Muscle
Exercise Limitations and Cardiopulmonary Exercise Testing in COPD
Clinical Assessment of Control of Breathing
Physiology and Pathobiology of the Lung Circulation
Sleep in Patients with COPD
The Physiology of Cough
The Physiology of Gas Exchange
COPD and Allied Conditions
The Natural History of COPD
Cystic Fibrosis
Bronchiectasis and COPD
Obliterative Bronchiolitis
Asthma
COPD: Clinical Presentation and Evaluation
Monitoring and Outcomes
Host Defences and Inflammation
Mucociliary Clearance
Mucosal Immunity
COPD and Pulmonary Surfactant
The Macrophage and its Role in the Pathogenesis of COPD
Eosinophils and COPD
Airway Epithelial Defence, Repair and Regeneration
The Role of the Neutrophil in the Pathogenesis of COPD
Lymphocytes
Cytokines
Leukotrienes in COPD: The Unexploited Potential
Cigarette Smoking, Emphysema and Lung Endothelium
Mesenchymal Cells of the Lung
Pathogenesis
Lung Development
Animal Models
Proteinases and COPD
Oxidants
Cigarette Smoke-Induced Disease
COPD and Air Pollution
Viruses in COPD
Bacteria
Genetic Factors
I?1-Antitrypsin Deficiency
Body Weight and Systemic Effects
Lung Connective Tissue
Clinical Considerations and Complications
Aerosols and Delivery Systems
Gastro-oesophageal Reflux
Upper Airway Diseases
Acute Pulmonary Embolism
COPD and Lung Cancer
Infection Management and Airflow Obstruction
Mechanical Ventilation for Exacerbation of COPD
Comorbidity
Current and Future Treatment
Primary Care
Pulmonary Rehabilitation
Social Support
Long-Term Invasive Mechanical Ventilation
Smoking Cessation
Oxygen Therapy in COPD
Surgical Therapy for COPD
Anti-cholinergics in COPD
Beta2-agonists
Corticosteroids
Phosphodiesterase 4 Inhibitors in the Treatment of COPD
Antibiotic Therapy in Patients with COPD
Antioxidants
Mucolytics for COPD
End-of-life and Palliative Care of Patients with COPD
Economic Burden of COPD
Pharmacoepidemiology of COPD
Social and Behavioural Impact of COPD - Research Opportunities
Guidelines
Pharmacotherapy: Developing Therapies
Protease Inhibitors
Retinoids
Chemokines in COPD
Index
Table of Contents provided by Publisher. All Rights Reserved.

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Chronic Obstructive Pulmonary Disease

Summary

Author Biography

Table of Contents

Supplemental Materials