Circadian Medicine

Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease.

Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration.

Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.

Part I: Fundamental Concepts

Introduction: Colwell

1. Molecular clockwork and the determinants of human circadian clock
Steve Brown, University of Zurich,

2.SCN Circuitry with a focus on outputs including ANS, body temperature
Rae Silver, Columbia University, Ruud Buijs, Universidad Nacional Autónoma de México

3. Sleep and circadian rhythms: partners in the regulation of behavior.
Mistlberger RE, Simon Fraser University, Burnaby, BC, Canada OR T. Deboer, Leiden University, NL

4. Circadian Sleep disorders
Phyllis C. Zee, Sleep Disorders Center, Northwestern University OR Derk-Jan Dijk,  University of Surrey

5. Sleep and circadian rhythms: reciprocal partners in the regulation of behavior.
Mistlberger RE, Simon Fraser University, Burnaby, BC, Canada or T. Deboer, Leiden Univeristy, NL

6. Circadian regulation of arousal and role in chronic fatigue
Mary Harrington, Smith College  

Part II: Circadian regulation of major organ system

7. Physiology of the adrenal and liver circadian clocks
Henrik Oster, Max-Planck Institute Biophysical Chemistry Goettingen Germany

8. Nutrition and diet as potent regulators of the liver clock.
Shigenobu Shibata; Waseda University, Tokyo, Japan;

9. Desynchrony of the human circadian system as a cause of pathophysiology in the heart
and pancreas.
Frank Scheer, Harvard University,

10. Cardiomyocyte circadian clock OR Circadian Clocks in the Vasculature
M.E. Young, University of Alabama; Garret A. Fitzgerald, M.D (University of Pennsylvania)

11. Integration of Circadian Mechanisms and Energy Balance
Joseph Bass, Northwestern University

12. Disruption of circadian rhythms and development of diabetes
Aleksey V. Matveyenko, University of California Los Angeles

13. Respiratory clocks
Hitoshi Okamura, Kyoto University, Japan

14. Circadian clock control of the cellular response to DNA damage and cancer.
Sancar, A, University of North Carolina School of Medicine, Chapel Hill, NC

Part III: clocks in the central nervous system:

15. Sleep and circadian regulation of vigilance and cognitive performance in humans
Ken P Wright, Jr. Center for Neuroscience, University of Colorado, Boulder, CO

16. Circadian clock, reward, and addictive behaviors
Albrecht U, University of Fribourg, Fribourg, Switzerland:

17. Circadian rhythms and mood disorders
McClung, CA; University of Pittsburgh Medical School,

18. Circadian regulation of memory processes
Colwell CS

Part IV: Aging and neurodegeneration

19. Is circadian dysfunction an integral symptom of Schizophrenia?
Foster RG, University of Oxford, Oxford, UK

20. Alzheimer’s disease and the mistiming of behavior.
Antle M, University of Calgary, Calgary, Canada

21. Circadian dysfunctional in Huntington's disease
Morton AJ, University of Cambridge, Cambridge, United Kingdom

22. The Aging clock
Block GD, University of California Los Angeles:

23. Social jet lag and the costs of 24/7 society
Till Roenneberg, Ludwig-Maximilians-University Munich

24. How shift work and a destabilized circadian system may increase risk for development of cancer and type 2 diabetes.  
Eva Schemhammer, Harvard University

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