Clinical Applications of Magnetic Resonance

This book is an introduction to the basic principles of magnetic resonance spectroscopy (MRS) and an overview of the emerging role of clinical MRS in neurologic and oncologic imaging. The book introduces the basic science of proton and phosphorous spectroscopy; reviews the current literature on MRS; and provides an overview of the clinical application of MRS in the evaluation of lymphoma, head and neck cancers, and brain tumors, as well as Alzheimer's disease, stroke, and epilepsy.

Foreword

ix

(2)

Preface

xi

(2)

Acknowledgments

xiii

(2)

Contributors

xv

1 Clinical Proton Magnetic Resonance Spectroscopy: Basic Principles

1

(32)

Lester Kwock, Ph.D.

2 Magnetic Resonance Spectroscopy in the Evaluation of Epilepsy

33

(16)

Jill E. Thompson, M.D.

Mauricio Castillo, M.D.

Lester Kwock, Ph.D.

3 Proton Magnetic Resonance Spectroscopy of Brain Tumors

49

(30)

Mauricio Castillo, M.D.

Lester Kwock, Ph.D.

4 Proton Magnetic Spectroscopy in Selected Childhood Disorders

79

(26)

Mauricio Castillo, M.D.

Lester Kwock, Ph.D.

5 Magnetic Resonance Spectroscopy and Spectroscopic Imaging for Cerebrovascular Disease

105

(38)

James N. Suojanen, M.D., P.E.

Peter B. Barker, Ph.D.

6 Magnetic Resonance Spectroscopy of Degenerative Brain Disease in the Elderly

143

(20)

R. Gilberto Gonzalez, M.D., Ph.D.

Thomas Ptak, M.D., Ph.D.

7 Magnetic Resonance Spectroscopy of the Head and Neck

163

(40)

Suresh K. Mukherji, M.D.

Sharon Schiro, Ph.D.

Lester Kwock, Ph.D.

8 New Techniques in Magnetic Resonance Spectroscopy: Potential Clinical Applications

203

(20)

Sharon Schiro, Ph.D.

A. William Blackstock, M.D.

Suresh K. Mukherji, M.D.

9 Correlation of Magnetic Resonance Spectroscopy with other Functional Brain Imaging Techniques in Selected Neurologic Disorders

223

(50)

Jeffrey David Lewine, Ph.D.

William W. Orrison Jr., M.D.

Appendix: Directory of Proton Magnetic Resonance Spectra for Intracranial and Extracranial Pathology

273

(28)

Suresh K. Mukherji, M.D.

Mauricio Castillo, M.D.

Index

301

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Clinical Applications of Magnetic Resonance Spectroscopy

Summary

Table of Contents

Supplemental Materials