Clinical Hematology

, by Stiene-Martin, E. Anne, Ph.D.; Lotspeich-Steininger, Cheryl A.; Koepke, John A.

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ISBN: 9780397553211 | 0397553218
Cover: Hardcover
Copyright: 10/1/1997

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Major clinical textbook/reference for laboratory technology students and practitioners. Previous edition edited by Cheryl A. Lotspeich (c1992). Color plates and halftone illustrations. 58 U.S. contributors. DNLM: Hematologic Diseases.

PART I Introduction to Hematology

(56)

CHAPTER 1 Introduction to Clinical Hematology and Safety in the Hematology Laboratory

(8)

E. Anne Stiene-Martin

History of Clinical Hematology

(1)

Basic Terminology in Hematology

(1)

Safety in the Clinical Hematology Laboratory

(5)

Chapter Summary

(2)

CHAPTER 2 Specimen Collection for Hematology and Hemostasis

(11)

Raymond L. Olesinski

Specimen Collection by Venipuncture

(5)

Specimen Collection by Capillary Puncture

(1)

Specimen Collection From Indwelling Catheters

(1)

Specimen Collection for Coagulation Testing

(3)

Specimen Preparation for Platelet Function Testing

(1)

Defibrinated Specimens

(1)

Chapter Summary

(3)

CHAPTER 3 Preparation of Blood Films for Examination

(16)

Jean Shafer

Manual Blood Film Preparation

(5)

Automated Blood Films

(1)

Buffy Coat Preparation

(2)

Artifacts of Blood Film Preparation

(2)

Staining the Blood Film

(4)

Troubleshooting Stain Problems

(1)

Chapter Summary

(2)

CHAPTER 4 Basic Microscopy in Hematology

(10)

Barbara A. Smith Michael

Sherry Martin

Lois Lucas

Image Formation in Light Microscopy--The Essentials

(2)

The Compound Light Microscope

(3)

Types of Light Microscopy

(2)

Troubleshooting Problems and Quality Control Preventive Maintenance in Light Microscopy

(1)

Chapter Summary

(2)

CHAPTER 5 Hematopoiesis and Review of Genetics

(11)

Vincent Salvatore Galliocchio

Hematopoietic System Development

(1)

Bone Marrow Volume and Anatomy

(1)

Stem Cell Theories and Cell Production

(2)

Regulation of Stem Cell Development--Growth Factors and Hormones

(1)

Essentials of Genetics

(3)

Cytogenetics

(1)

Chapter Summary

(3)

PART II The Erythrocytes

(68)

CHAPTER 6 Normal Erythrocyte Production, Physiology, and Destruction

(16)

Marian Schwabbauer

Erythrocyte Production

(1)

Erythrocyte Maturation

(4)

Structure and Physiology of the Mature Erythrocyte

(4)

Erythrocyte Destruction

(1)

Regulation of Erythropoiesis (Erythrokinetics)

(3)

Chapter Summary

(3)

CHAPTER 7 Hemoglobin Synthesis and Function

(14)

F. Bernhard Ludvigsen

Components of Hemoglobin

(1)

Normal Hemoglobin Variants

(1)

Hemoglobin Structure and Synthesis

(4)

Locations of Hemoglobin During Function and Degradation

(1)

Physiologic Characteristics of Hemoglobin

(3)

Hemoglobin Derivatives and Their Associated Disorders

(2)

Abnormal Heme Synthesis: The Porphyrias

(1)

Laboratory Evaluation of Hemoglobin and Iron Availability

(1)

Chapter Summary

(3)

CHAPTER 8 Morphologic Evaluation of Erythrocytes

(19)

Ann Bell

Distribution

(1)

Normal Morphology

(1)

Size

(1)

Shape Variation--Poikilocytosis

(7)

Hemoglobin Content

(1)

Inclusions

(3)

Artifacts

100

(2)

Morphology Reporting

102

(1)

Approaching Erythrocyte Abnormalities on the Unknown Film

103

(1)

Chapter Summary

103

(3)

CHAPTER 9 Quantitative Laboratory Evaluation of Erythrocytes

106

(19)

Tina M. Riedinger

Bernadette F. Rodak

Spectrophotometric Determination of Hemoglobin Concentration (Hemoglobinometry)

106

(4)

Centrifuged Microhematocrit

110

(2)

Correlations and Calculations Based on Erythrocyte Measurements

112

(2)

Reticulocyte Counts

114

(3)

Erythrocyte Sedimentation Rate

117

(3)

Point of Care Testing

120

(2)

Units of Hematologic Measurement

122

(1)

Chapter Summary

122

(3)

PART III Erythrocyte Abnormalities

125

(178)

CHAPTER 10 Introduction to Erythrocyte Abnormalities

125

(14)

Dona D. Knapp

Absolute Versus Relative Erythrocyte Abnormalities

126

(1)

Laboratory Definition of Erythrocyte Abnormalities

126

(1)

Disorders Characterized by Decreased Erythrocyte Concentration

126

(8)

Disorders Characterized by Increased Erythrocyte Concentration

134

(2)

Chapter Summary

136

(1)

Case Studies

136

(3)

CHAPTER 11 Anemias of Bone Marrow Failure and Systemic Disorders

139

(16)

Joyce A. Behrens

Anemias of Bone Marrow Failure

139

(9)

Anemias of Systemic Disorders

148

(3)

Chapter Summary

151

(4)

CHAPTER 12 Anemias of Abnormal Nuclear Development

155

(20)

Cheryl A. Lotspeich-Steininger

Vitamin B(12) and Folate

156

(1)

The Megaloblastic Anemias

157

(3)

Pernicious Anemia

160

(2)

Laboratory Tests for Vitamin B(12) and Folate Deficiency

162

(4)

Other Causes of Acquired Vitamin B(12) Deficiency

166

(1)

Hereditary Vitamin B(12) Deficiency (Imerslund Syndrome)

167

(1)

Folate Deficiency Anemia

167

(1)

Conditions That Cause Both Folate and B(12) Deficiency

168

(1)

Inherited Disorders That Affect DNA Synthesis

168

(1)

Differential Diagnosis of the Megaloblastic Anemias

169

(1)

Congenital Dyserythropoietic Anemias

169

(1)

Chapter Summary

170

(5)

CHAPTER 13 Anemias of Abnormal Iron Metabolism and Hemochromatosis

175

(17)

William Koss

Laboratory Tests Useful in Differentiating Disorders of Iron Metabolism

176

(2)

Iron Deficiency Anemia

178

(3)

Anemia of Chronic Disease

181

(1)

Sideroblastic Anemias

182

(3)

Lead Intoxication

185

(1)

Hereditary and Acquired Hemochromatosis Iron Overload

186

(1)

Chapter Summary

187

(5)

CHAPTER 14 Anemias of Abnormal Globin Development--Hemoglobinopathies

192

(25)

Robbi Safko

Genetics of Abnormal Globin Chain Production

193

(1)

Nomenclature

193

(1)

Classification of Hemoglobinopathies

194

(1)

General Laboratory Findings

195

(1)

Most Useful Laboratory Tests for Diagnosing Hemoglobinopathies

195

(6)

Systematic Laboratory Diagnosis of Hemoglobinopathies

201

(1)

Variants Caused by XXX-Chain Substitutions

201

(7)

Multiple Amino Acid Substitutions

208

(1)

XXX-Chain Substitutions

208

(1)

Other Variants

208

(1)

Amino Acid Deletion

209

(1)

Elongation of the Polypeptide Chain

209

(1)

Unstable Hemoglobin Disease

209

(2)

Most Useful Laboratory Tests for Diagnosing Unstable Hemoglobins

211

(1)

The M Hemoglobins

212

(1)

Hemoglobins with Increased Oxygen Affinity

212

(1)

Hemoglobins with Decreased Oxygen Affinity

213

(1)

Chapter Summary

213

(4)

CHAPTER 15 Anemias of Abnormal Globin Development--Thalassemias

217

(24)

J. Lynne Williams

History

217

(1)

Demographics

217

(1)

Definitions and Nomenclature

218

(1)

Genetic Control of Globin Synthesis

218

(1)

Pathophysiology-General Principles

219

(1)

General Laboratory Testing for Thalassemia

220

(1)

XXX-Thalassemia

221

(4)

XXX-Thalassemia

225

(7)

Hereditary Persistence of Fetal Hemoglobin and XXX-Thalassemia

232

(1)

Thalassemia with Abnormal Hemoglobin Variants

232

(1)

Unusual Forms of Thalassemia

233

(1)

Differentiation of Iron Deficiency Anemia and Thalassemia

234

(1)

Most Useful Laboratory Tests for Diagnosing Thalassemia

234

(3)

Special Laboratory Procedures for Diagnosing Thalassemia

237

(1)

Chapter Summary

237

(4)

CHAPTER 16 Introduction to Anemias of Increased Erythrocyte Destruction

241

(11)

Loretta Nemchik

Classification

241

(1)

Sites of Erythrocyte Hemolysis

242

(1)

Erythrocyte Catabolism

243

(2)

Laboratory Findings and Correlations with Disease

245

(3)

Erythrokinetics

248

(1)

Chapter Summary

249

(3)

CHAPTER 17 Hereditary Anemias of Increased Destruction

252

(16)

Dianne M. Hansen

Hereditary Erythrocyte Membrane Abnormalities

252

(7)

Hereditary Erythrocyte Enzymopathies

259

(5)

Hereditary Plasma Constituent Abnormalities

264

(1)

Chapter Summary

265

(3)

CHAPTER 18 Acquired Nonimmune Anemias of Increased Destruction

268

(12)

Susan J. Leclair

Microangiopathic Hemolytic Anemia

268

(6)

Cardiac and Large Vessel Abnormalities

274

(1)

Miscellaneous Extracorpuscular Mechanisms of Injury

274

(1)

Acquired Intracorpuscular Mechanisms of Injury

274

(3)

Acquired Intracorpuscular Defects

277

(1)

Chapter Summary

277

(3)

CHAPTER 19 Acquired Immune Anemias of Increased Destruction

280

(13)

Catherine Sherry

Hemolysis in Acquired Immune Hemolytic Anemia

280

(3)

Alloimmune Hemolytic Anemia

283

(2)

Autoimmune Hemolytic Anemia

285

(3)

Drug-Induced Immune Hemolytic Anemia

288

(2)

Chapter Summary

290

(3)

CHAPTER 20 Anemias of Blood Loss

293

(5)

Kathleen M. Mugan

Acute Blood Loss

293

(2)

Chronic Blood Loss

295

(1)

Chapter Summary

296

(2)

CHAPTER 21 Systematic Laboratory Evaluation of Erythrocyte Abnormalities

298

(5)

John A. Koepke

The Physician's Role in the Diagnostic Process

298

(1)

Laboratory Evaluation of Anemia

299

(2)

Epilogue

301

(2)

PART IV The Leukocytes

303

(44)

CHAPTER 22 The Phagocytic Leukocytes--Morphology, Kinetics, and Function

303

(14)

Louann W. Lawrence

Introduction to the Leukocytes

303

(3)

The Neutrophil

306

(5)

The Eosinophil

311

(1)

The Basophil

312

(1)

The Monocyte

313

(1)

Chapter Summary

314

(3)

CHAPTER 23 Immune Leukocytes--Morphology, Kinetics, and Function

317

(14)

F. Sue Allison

Physiologic Characteristics of Lymphocytes

317

(1)

Characterization of Lymphocytes and Plasma Cells

318

(1)

Lymphopoiesis

319

(6)

Lymphokinetics

325

(1)

Function

326

(2)

Chapter Summary

328

(3)

CHAPTER 24 Laboratory Evaluation of Leukocytes

331

(16)

Joan C. Terrell

Manual Leukocyte Counts

331

(5)

Manual Differential Cell Counts

336

(6)

Absolute Eosinophil Counting Procedure

342

(1)

Absolute Basophil Counting Procedure

343

(1)

Considerations in Evaluating Leukocytes From Pediatric Patients

343

(1)

Antinuclear Antibody (ANA) Test

343

(1)

Chapter Summary

344

(1)

Exercises

344

(3)

PART V Leukocyte Abnormalities (Nonmalignant)

347

(26)

CHAPTER 25 Nonmalignant, Reactive Disorders of Leukocytes

347

(17)

Virginia Haigh

E. Anne Stiene-Martin

Neutrophils

348

(4)

Eosinophils

352

(2)

Basophils

354

(1)

Monocytes

354

(1)

Lymphocytes

355

(5)

Leukemoid Reactions

360

(1)

Chapter Summary

361

(3)

CHAPTER 26 Nonmalignant Hereditary Disorders of Leukocytes

364

(9)

Angela B. Foley

Inherited Abnormalities of Granulocyte Morphology

364

(1)

Inherited Abnormalities of Granulocyte Function

365

(2)

Inherited Disorders of the Monocyte--Macrophage System

367

(2)

Inherited Disorders of Immune Leukocytes

369

(1)

Chapter Summary

370

(3)

PART VI Special Hematologic Evaluations

373

(54)

CHAPTER 27 Preparation and Evaluation of Bone Marrow

373

(13)

Karen G. Lofsness

Ella M. Spanjers

Collection of Marrow Specimens

375

(2)

Processing of Specimens

377

(1)

Staining of Specimens

378

(1)

Normal Marrow Cells

379

(2)

Evaluation of Marrow Preparations

381

(2)

Marrow Differential

383

(1)

Preparation of the Final Report

384

(1)

Chapter Summary

384

(2)

CHAPTER 28 Hematopoietic Stem Cells for Transplantation

386

(7)

Lynne H. Lyons

Gary Van Zant

Allogeneic Transplantation of Marrow

386

(1)

Autologous Transplantation

387

(1)

Graft Cryopreservation

387

(1)

Graft Engineering

387

(2)

Laboratory Assessment

389

(1)

Future Development

389

(1)

Chapter Summary

390

(3)

CHAPTER 29 Cytochemistry

393

(7)

Edward S. Rappaport

Barbara J. Helbert

History of Cytochemistry

393

(1)

Factors to Consider Before Initiating Cytochemical Stains

393

(1)

Procedural Summaries

394

(1)

Enzymatic Techniques

394

(2)

Nonenzymatic Techniques

396

(1)

Immunocytochemistry

397

(1)

The Future of Cytochemistry

398

(1)

Chapter Summary

398

(2)

CHAPTER 30 Laboratory Evaluation of Body Fluids

400

(15)

Joy Jarvis Gall

Cerebrospinal Fluid

400

(9)

Serous Fluid

409

(2)

Synovial Fluid

411

(1)

Miscellaneous Fluids

412

(1)

Chapter Summary

413

(2)

CHAPTER 31 Molecular Testing in Hematology

415

(12)

Jennifer K. Morrow

Basic Principles of Molecular Biology

415

(1)

Molecular Testing

416

(5)

Hematologic Applications

421

(2)

Chapter Summary

423

(4)

PART VII Malignant Myeloproliferative Disorders

427

(46)

CHAPTER 32 Introduction to the Hematopoietic Malignancies

427

(3)

E. Anne Stiene-Martin

CHAPTER 33 The Dysmyelopoietic Disorders

430

(12)

Robert V. Pierre

Definition of Dysmyelopoietic Syndromes and Relation to Other Clonal Myeloproliferative Disorders

430

(1)

History of Disease

431

(1)

Pathophysiology

431

(1)

Clinical Presentation

431

(1)

Peripheral Blood and Bone Marrow Abnormalities

432

(1)

Specific Clinicopathologic Forms of Dysmyelopoietic Syndromes

433

(3)

Survival and Progression to Acute Leukemia

436

(1)

Laboratory Tests Most Useful in the Diagnosis of DMPS

437

(1)

Follow-Up Observations and Treatment

438

(1)

Chapter Summary

439

(3)

CHAPTER 34 Acute Myeloproliferative Leukemia (Acute Nonlymphocytic Leukemia)

442

(13)

Valerie J. Evans

Definition

442

(1)

Etiology

442

(1)

Classification

443

(7)

Treatment

450

(2)

Chapter Summary

452

(3)

CHAPTER 35 Chronic Myeloproliferative Disorders

455

(18)

Irma T. Pereira

General Considerations

455

(1)

Polycythemia Vera

456

(3)

Chronic Myelogenous Leukemia

459

(3)

Juvenile Chronic Myelogenous Leukemia

462

(1)

Agnogenic Myeloid Metaplasia

463

(2)

Essential Thrombocythemia

465

(2)

Chronic Neutrophilic Leukemia

467

(1)

Drugs Used in Chronic Myeloproliferative Disorders

468

(5)

Chapter Summary

PART VIII Malignant Lymphoproliferative Disorders

473

(42)

CHAPTER 36 Acute Lymphoblastic Leukemias

473

(9)

Anne S. Hobson

Clinical Manifestations

474

(1)

Causes of Death

474

(1)

Laboratory Findings

474

(1)

Classification of Acute Lymphoblastic Leukemia

475

(3)

Effects of Treatment on Laboratory Results

478

(2)

Chapter Summary

480

(2)

CHAPTER 37 Chronic Lymphoproliferative Leukemic Disorders

482

(8)

Rita C. East

Chronic Lymphocytic Leukemia

482

(2)

Prolymphocytic Leukemia

484

(1)

Hairy Cell Leukemia

485

(1)

Chapter Summary

486

(4)

CHAPTER 38 The Lymphomas

490

(13)

Charles E. Manner

Principal Classifications of Lymphoma

490

(1)

Hodgkin Disease

491

(5)

Non-Hodgkin Lymphomas

496

(3)

Mycosis Fungoides and Sezary Syndrome

499

(1)

Chapter Summary

500

(3)

CHAPTER 39 Plasma Cell Disorders (Paraproteinemias)

503

(8)

Sandra Sommer

Review of Immunoglobulins

503

(1)

Multiple Myeloma (Plasma Cell Myeloma)

504

(3)

Plasma Cell Leukemia

507

(1)

Waldenstrom's Macroglobulinemia

507

(1)

Heavy Chain Diseases

508

(1)

Amyloidosis

508

(1)

Monoclonal Gammopathy of Uncertain Significance

509

(1)

Chapter Summary

509

(2)

CHAPTER 40 Systematic Laboratory Evaluation of Leukocyte Abnormalities

511

(4)

John A. Koepke

Reactions and Disorders

511

(1)

Myeloproliferation

511

(1)

Lymphoproliferation

512

(1)

The Physician's Role in the Diagnostic Process

512

(1)

Laboratory Evaluation of Leukocyte Abnormalities

513

(1)

Peripheral Blood and Bone Marrow Evaluation

513

(1)

Lymph Node Biopsy

514

(1)

PART IX Instrumentation for Hematologic Evaluation

515

(48)

CHAPTER 41 Introduction to Hematologic Automation

515

(4)

E. Anne Stiene-Martin

CHAPTER 42 Multiparameter Hematology Instruments

519

(33)

Mary Ann Dotson

Development of Automated Analyzers

520

(2)

General Principles of Instrument Operation

522

(3)

Principal Instrument Systems

525

(15)

General Considerations

540

(4)

Utilization of Computer Data

544

(3)

Chapter Summary

547

(5)

CHAPTER 43 Flow Cytometry

552

(11)

Jeffrey Louie

John W. Parker

History

552

(1)

Principal Features of Flow Cytometry

552

(3)

Quality Assurance

555

(1)

Clinical Applications

556

(4)

Emerging Applications

560

(1)

Current Use

561

(1)

Chapter Summary

561

(2)

PART X Quality Control and Quality Assurance

563

(36)

CHAPTER 44 Introduction to Quality Control and Quality Assurance in Hematology

563

(16)

John A. Koepke

History of Laboratory Quality Control

564

(1)

Method and Instrument Evaluation and Selection

564

(2)

Concepts and Statistical Methods Used in Quality Control

566

(9)

Components of a Quality Assurance Program

575

(2)

Chapter Summary

577

(2)

CHAPTER 45 Methods to Monitor and Control Systematic Error

579

(12)

Mary Ann Dotson

Calibration

579

(2)

Use of Controls

581

(2)

Quality Control Charts and Their Interpretation

583

(2)

Statistical System for Quality Control

585

(2)

Instrument Maintenance

587

(1)

Troubleshooting Procedures

587

(1)

Quality Control Documentation

587

(1)

Internal Laboratory Monitoring

588

(1)

External Laboratory Monitoring

588

(1)

Chapter Summary

589

(2)

CHAPTER 46 Methods to Monitor and Control Random Error

591

(8)

John A. Koepke

Definition

591

(1)

Quality Control and Random Error

591

(3)

Use of Instrument and Laboratory Information Systems for the Detection of Random Errors

594

(2)

A System for the Detection and Control of Laboratory Errors

596

(1)

Chapter Summary

596

(3)

PART XI Hemostasis

599

(150)

CHAPTER 47 Introduction to Hemostasis

599

(13)

Cheryl A. Lotspeich-Steininger

The Three Hemostatic Components

600

(1)

Concepts of Normal Hemostasis, Hypocoagulation, and Hypercoagulation

600

(1)

Historical Background of Hemostasis

601

(1)

Historical Development of Clinical Hemostasis

601

(1)

The Hemostasis Laboratory Today

601

(1)

Overview of the Hemostatic Mechanism

601

(5)

Basic Terminology for Clinical Findings in Bleeding Disorders

606

(1)

Bleeding Disorders Caused by Vascular Defects

606

(4)

Chapter Summary

610

(2)

CHAPTER 48 Mechanisms of Coagulation and Fibrinolysis

612

(23)

Muriel I. Jobe

Hemostasis Overview

612

(1)

The Coagulation Proteins

613

(1)

Coagulation and the Kinin System

613

(2)

Coagulation and the Complement System

615

(1)

The Coagulation Factors

615

(1)

The Coagulation Factor Groups

615

(3)

Phospholipids Contributing to Coagulation

618

(2)

Physiologic Variations of the Coagulation Factors

620

(1)

The Process of Fibrin Clot Formation

620

(3)

The Fibrinolytic System

623

(3)

Inhibitors of Coagulation and Fibrinolysis

626

(4)

Chapter Summary

630

(5)

CHAPTER 49 Routine and Special Laboratory Evaluation of Coagulation

635

(15)

Cheryl S. Cook

Reference Ranges

636

(1)

Testing Methodologies

636

(1)

Routine Tests for the Intrinsic and Common Pathways

637

(2)

Routine Tests for the Extrinsic and Common Pathways

639

(1)

Other Routine Tests

639

(1)

Special Tests for Coagulation Proteins or Systems

640

(2)

Inhibitor Studies

642

(1)

Inhibitor Identification and Quantitation

642

(1)

Factor Assays

643

(2)

Regulatory Proteins Assays

645

(1)

Other Special Tests

646

(1)

Chapter Summary

646

(4)

CHAPTER 50 Laboratory Evaluation of Fibrinolysis

650

(7)

Gordon E. Ens

Determination of Lysis Time

650

(1)

Determination of Lysis Products

651

(2)

Determination of Proteins Involved in Lysis

653

(1)

Chapter Summary

654

(3)

CHAPTER 51 Markers of Thrombotic Activity

657

(4)

Gordon E. Ens

Definition and Diagnostic Applications

657

(1)

Thrombin-Antithrombin Complex

657

(1)

Prothrombin Fragment 1.2

658

(1)

Fibrinopeptide A

658

(1)

D-Dimer

659

(1)

Chapter Summary

659

(2)

CHAPTER 52 Hemorrhagic Disorders of Coagulation and Fibrinolysis

661

(14)

Margaret C. Schmidt

Inherited Disorders of Coagulation

661

(7)

Acquired Abnormalities of Coagulation and Fibrinolysis

668

(4)

Chapter Summary

672

(3)

CHAPTER 53 Disorders Leading to Thrombosis

675

(7)

Gordon E. Ens

Pathophysiology

675

(1)

Primary Disorders Leading to Thrombosis

675

(3)

Secondary Disorders of Thrombosis

678

(2)

Chapter Summary

680

(2)

CHAPTER 54 Laboratory Monitoring of Anticoagulant Therapy

682

(7)

Jamie Siegel

Powers Peterson

Heparin Therapy

682

(2)

Oral Anticoagulants

684

(1)

Antiplatelet Function Therapy

685

(1)

In Vivo Lysis of Thrombi

686

(1)

Chapter Summary

687

(2)

CHAPTER 55 The Megakaryocyte--Platelet System

689

(18)

Robert Rifkin

Megakaryocyte Maturation and Structure

689

(4)

Platelet Structure

693

(4)

Thrombokinetics--Platelet Life Span and Turnover Rate

697

(1)

Platelet Function and Primary Hemostasis

697

(5)

Chapter Summary

702

(5)

CHAPTER 56 Laboratory Evaluation of Platelets

707

(10)

John A. Koepke

Platelet Counting

707

(2)

Evaluation of Platelet Function

709

(4)

Evaluation of Platelets in the Diagnosis of Von Willebrand Disease

713

(2)

Chapter Summary

715

(2)

CHAPTER 57 Quantitative and Qualitative Disorders of Platelets

717

(18)

Gerald L. Davis

Quantitative Platelet Disorders: Thrombocytopenia

717

(9)

Quantitative Platelet Disorders: Thrombocytosis

726

(1)

Qualitative Platelet Disorders: Inherited

726

(3)

Qualitative Platelet Disorders: Acquired

729

(1)

Chapter Summary

730

(5)

CHAPTER 58 Instrumentation and Quality Control in Hemostasis

735

(14)

Ruth Ann Henrikson

Robert A. Van Dyne

Instrumentation for Tests of Hemostasis

735

(4)

Quality Control for Instrument Operation

739

(1)

Quality Control for Hemostasis Testing

739

(4)

Coagulation Point-of-Care Testing

743

(1)

Aggregometry Quality Control

744

(1)

Synthetic Substrates in Tests of Hemostasis

745

(1)

Chapter Summary

746

(3)

APPENDICES

749

(18)

A Answers to Case Studies

749

(14)

B Answers to Review Questions

763

(2)

C Percent Transmittance-Absorbance Conversion Table

765

(1)

D Relative Centrifugal Force Nomograph

766

(1)

Glossary

767

(25)

List of Abbreviations

792

(1)

Index

793

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Clinical Hematology

Summary

Table of Contents

Supplemental Materials

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Clinical Hematology

Summary

Table of Contents

Supplemental Materials

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