Clinical Manual of Blood and Bone Marrow Transplantation

• Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions
• Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program
• Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral
• Benefits from expert contributions from an international authorship

Syed A. Abutalib, MD, Assistant Director, Hematology & Bone Marrow Transplantation Program; Director, Hematopoietic Progenitor Cell Collection Facility, Midwestern Regional Medical Center, Cancer Treatment Centers of America, Zion, IL, USA

Parameswaran Hari, MD, MRCP, MS, Armand Quick – William Stapp Professor of Hematology; Interim Division Chief, Division of Hematology and Oncology; Director, Adult Blood and Marrow Transplant Program; Medical College of Wisconsin, Milwaukee, WI, USA

Contributors, ix

Preface, xiv

1 Donor and graft selection strategy, 1
Ayman Saad, Marisa B. Marques, and Shin Mineishi

2 HLA typing and implications, 9
Bronwen E. Shaw and Stephen R. Spellman

3 Risk�]benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models, 19
Mahmoud Elsawy and Mohamed L. Sorror

4 Donor and recipient pre�]transplant evaluation, 36
Shuang Fu and Navneet S. Majhail

5 Autologous and allogeneic progenitor cell mobilization, 45
Racquel D. Innis�]Shelton and Luciano J. Costa

6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks, 53
Anand Padmanabhan

7 Hematopoietic cell processing: From procurement to infusion, 59
Jay S. Raval, Kathryn McKay, and Yara A. Park

8 Graft manipulation: T-cell depletion and beyond, 66
Christina Cho and Miguel�]Angel Perales

9 Graft�]versus�]host disease prophylaxis, 73
Melhem Solh and Asad Bashey

10 Acute lymphoblastic leukemia, 80
Ghada Zakout and Adele K. Fielding

11 Acute myeloid leukemia, 89
Hillard M. Lazarus and Masumi Ueda

12 Myelodysplastic syndromes, 97
Melinda Biernacki and H. Joachim Deeg

13 Chronic myelogenous leukemia, 108
Daniel Egan and Jerald Radich

14 Philadelphia chromosome negative myeloproliferative neoplasms, 116
Nicolaus Kröger

15 Chronic lymphocytic leukemia, 123
Fabienne McClanahan Lucas and John Gribben

16 Hodgkin Lymphoma, 131
Anna Sureda and Eva Domingo�]Domenech

17 Indolent lymphomas, 140
Narendranath Epperla, Hamza Hashmi, and Mehdi Hamadani

18 Diffuse large B-cell lymphoma, 151
Syed Abbas Ali, Istvan Redei, and Syed A. Abutalib

19 Mantle cell lymphoma, 164
Narendranath Epperla and Timothy S. Fenske

20 T-cell lymphoma, 179
Adrienne A. Phillips and Koen van Besien

21 Primary CNS lymphoma, 188
Henry C. Fung, Philip Pancari, and Patricia Kropf

22 Autologous hematopoietic transplant in multiple myeloma, 194
Nisha S. Joseph, Ajay K. Nooka, and Sagar Lonial

23 Allogeneic hematopoietic transplant in multiple myeloma, 207
Parameswaran Hari and Binod Dhakal

24 Light�]chain amyloidosis, 214
Amara S. Hussain and Anita D’Souza

25 Autoimmune disorders, 221
Adam Bryant and Harold Atkins

26 Testicular cancer, 229
Moshe C. Ornstein, Navneet S. Majhail, and Timothy Gilligan

27 Sickle cell disease, 236
Sonali Chaudhury and Shalini Shenoy

28 Hematopoietic cell transplant in thalassemia, 246
Emanuele Angelucci and Federica Pilo

29 Fanconi anemia, 255
Flore Sicre de Fontbrune, Jean Soulier, and Regis Peffault de Latour

30 Immunodeficiency disorders, 264
Jennifer A. Kanakry and Dennis D. Hickstein

31 Inherited metabolic disorders, 272
Jaap Jan Boelens and Robert F. Wynn

32 Aplastic anemia and paroxysmal nocturnal hemoglobinuria, 281
Andrew C. Dietz and Michael A. Pulsipher

33 HIV infection and transplantation, 290
Nitya Nathwani, Stephen J. Forman, and Amrita Krishnan

34 Engraftment and graft failure: Assessment and practical considerations, 297
Yogesh Jethava, Madan Jagasia, Mohamed Mohty, and Bipin N. Savani

35 Immune reconstitution and tolerance, 304
udovic Belle and William R. Drobyski

36 Donor lymphocyte infusion, 315
David C. Halverson and Daniel Fowler

37 Diagnosis and treatment of acute graft�]versus�]host disease, 324
Natasha Kekre and Vincent T. Ho

38 Diagnosis and treatment of chronic graft�]versus�]host disease, 334
Sabarinath Venniyil Radhakrishnan and Daniel R. Couriel

39 Prevention and treatment of infection, 348
Corrado Girmenia, Gian Maria Rossolini, and Claudio Viscoli

40 Early non�]infectious complications after hematopoietic cell transplantation, 359
Piyanuch Kongtim and Stefan O. Ciurea

41 Post�]transplant lymphoproliferative disorders, 369
Michael D. Keller, Conrad R. Cruz, and Catherine M. Bollard

42 Survivorship issues after transplantation, 376
Vanessa E. Kennedy, Madan Jagasia, and Bipin N. Savani

Index, 384

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