Cognitive Dimensions of Major Depressive Disorder

Major depressive disorder (MDD) is one of the most prevalent mental disorders worldwide, and is estimated to affect 300 million people. Most research defines MDD as a categorical disorder and investigations on clinical, functional, and biological correlates are assessed by established diagnostic instruments. However, given the phenotypic and biological heterogeneity of depression, a re-focus on the clinical phenotype of MDD is required.

Bridging psychiatric and psychological traditions Cognitive Dimensions of Major Depressive Disorder, discusses the characteristics of the dimensional approach of MDD. Focusing on the cognitive and emotional processes of depression, this guide offers extended and novel diagnostic and treatment approaches ranging from pharmacological to psychological interventions targeting dimensions of depression.

Edited by pioneers in this field, this resource discusses hot topics such as how to define the dimensional approach to depression, the neurobiological underpinnings of cognitive dysfunction in depression, and the impairment of emotional processing deficits in depression.

Cognitive Dimensions of Major Depressive Disorder is suitable for students, trainees, clinicians and scientists in the fields of psychology, neuropsychology, psychiatry, cognitive neuroscience, neurology, general practice and also for various other health care professionals.

Bernhard T. Baune, Cato Chair and Head of Department of Psychiatry, Melbourne Medical School, The University of Adelaide,Catherine Harmer, Professor of Cognitive Neuroscience, Department of Psychiatry, University of Oxford, UK

Prof. Bernhard T. Baune is Cato Chair and Head of the Department of Psychiatry at The University of Melbourne, Australia. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP), Australia. He leads an extensive research program into personalised psychiatry, prediction and biomarker research in psychiatry and treatment response prediction and in neuroimmunology. Key research achievements include an in-depth understanding of the interaction between the immune and nervous system, the development of a systems biology approach for response prediction and the establishment of innovative personalised clinical trials in major psychiatric disorders. He has a particular interest in cognitive function and psychosocial function in psychiatric disorders and in the severe course of mental illness, treatment response and recovery.

Prof. Catherine Harmer is the director of the Psychopharmacology and Emotional Research Lab (PERL) based at the University Department of Psychiatry in Oxford, which comprises a multi-disciplinary team including graduate research assistants, DPhil students, post-doctoral researchers, Psychiatrists and Pharmacologists.
The research of the group focuses on the psychological mechanisms of antidepressant drug action by exploring drug effects on human models of emotional processing. A range of methodologies are used, including neuropsychological testing, transcranial magnetic stimulation and functional neuroimaging with fMRI and PET in healthy volunteers and patient samples. This research has the potential to integrate psychological and pharmacological views of depression and treatment and has challenged the way in which we typically consider drug treatment for depression to work.

Section I Major depressive disorder as a multi-dimensional disorder
1. Functional and psychosocial consequences of major depressive disorder, Tracy L. Greer and Jeethu K. Joseph
2. Opportunities and challenges of the phenotypic heterogeneity of major depressive disorder, Koen Demyttenaere
3. Major depressive disorder as a disorder of cognition, Muzaffer Kaser and Barbara J. Sahakian
Section II Cognitive Dysfunction in Depression
4. Cognitive Dysfunction as a symptom dimension across major psychiatric disorders, Zihang Pan and Roger S. McIntyre
5. Clinical and functional characteristics of cognitive dysfunction in major depressive disorder, Maria Serra-Blasco and Raymond W. Lam
6. The assessment of cognitive dysfunction in major depressive disorder, John E. Harrison
7. Molecular neurobiology of cognitive dysfunction in MDD, Natalie T. Mills and Bernhard T. Baune
Section III Impaired emotional processing in MDD
8. Clinical characteristics of emotional-cognitive dysfunction in MDD, Thomas Beblo and Lorenz Dehn
9. Neurocircuitries of emotion processing affected in Major Depressive Disorder, Anjali Sankar and Cynthia H.Y. Fu
10. The neural circuitry of negative bias, oversensitivity to negative feedback and hyposensitivity to reward in MDD, Oliver J. Robinson
11. Reward processing in adolescents with depression, Georgia O'Callaghan and Argyris Stringaris
12. Cognition-related brain networks underpin cognitive, emotional and somatic symptom dimensions of depression, Genevieve Rayner
13. Networks of cognitive processes: Functional and anatomical correlates of cognition, emotions and social cognition, John D. Medaglia
14. The neurobiology of emotion-cognition interactions, Thalia Richter, Alexander J. Shackman, Tatjana Aue, and Hadas Okon-Singer
Section IV Social cognitive processes in Depression
15. Clinical characteristics of social cognitive processes in Major Depressive Disorder, Katharina Foerster, Silke Joergens, and Bernhard T. Baune
16. Understanding of self and others: neurobiological underpinnings of social cognition, Franziska K. Goer and Rebecca Elliott
17. Emotional and cognitive consequences of social rejection: An entry door to major depression, Philippe Fossati, Sophie Hinfray, Anna Fall, Cedric Lemogne, and Jean-Yves Rotge
Section V Interventions and Management
18. Pharmacological interventions for cognitive dysfunction in MDD, Marco Solmi, Beatrice Bortolato, Brendon Stubbs, Nathan Herrmann, and Andre F. Carvalho
19. Psychological interventions for cognitive dysfunction in MDD, Claudia Woolf, Loren Mowszowski, and Sharon Naismith
20. Can non-pharmacological antidepressant treatments influence the processing of affective informationa
21. Novel treatment opportunities in major depressive disorder, Michael James Weightman and Bernhard T. Baune