The Comet Assay in Toxicology

Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive, rapid and visual, this modern toxicological method allows quantitative and qualitative assessment of DNA damage in single cells.This unique reference is devoted exclusively to the Comet assay and addresses, in-depth, the different protocols, statistical analyses and applications being used worldwide. It also includes the guidelines recommended by the working group on Comet assay.