Corneal Cross-Linking

Dedication

About the Editors

About the Associate Editor

Contributing Authors

Foreword by Eberhard Spoerl, PhD, and Theo Seiler, MD, PhD

Introduction

Section I          Basic Principles of Corneal Biomechanics and Corneal Cross-Linking

Chapter 1            History of Corneal Cross-Linking

                             Eberhard Spoerl, PhD, and Frederik Raiskup, MD, PhD, FEBO

Chapter 2            Introduction to Corneal Biomechanics

                             William J. Dupps Jr, MD, PhD

Chapter 3            Fundamental Principles of Corneal Cross-Linking

                             Gregor Wollensak, MD

Chapter 4            Riboflavin, Ultraviolet Light, and the Photochemical Reaction

                            Arie L. Marcovich, MD, PhD, and Alexander Brandis, PhD

Chapter 5            The Role of Oxygen in Corneal Cross-Linking

                             Olivier Richoz, MD, PhD; Sabine Kling, PhD; and Farhad Hafezi, MD, PhD

Chapter 6            Cross-Linking Initiated by Other Chromophores and by Multiphoton Excitation

                             Irene Kochevar, PhD

Chapter 7            Corneal Cross-Linking Safety Considerations

                             Christina Giannikas Starcic, MD; Leejee H. Suh, MD; and Stephen L. Trokel, MD

Chapter 8            Molecular Aspects of Corneal Cross-Linking

                            Rohit Shetty, FRCS, PhD; Natasha Kishore Pahuja, DOMS; and Harsha Nagaraja, MS, FCE

Chapter 9            Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration

                             Marcony R. Santhiago, MD, PhD; Yaron S. Rabinowitz, MD; and J. Bradley Randleman, MD

Chapter 10          Evaluation and Diagnosis of Postoperative Corneal Ectasia

                             J. Bradley Randleman, MD; Maria A. Woodward, MD, MS; and Marcony R. Santhiago, MD, PhD

Section II        Corneal Cross-Linking for Corneal Ectasias

Chapter 11          Corneal Cross-Linking for Progressive Keratoconus

                            Tobias Koller, MD; Stefan Seiler, MD; and Theo Seiler, MD, PhD

Chapter 12          Corneal Cross-Linking for Postoperative Corneal Ectasia

                            David Tabibian, MD, and Farhad Hafezi, MD, PhD

Chapter 13          Corneal Cross-Linking for Pellucid Marginal Degeneration

                             Leopoldo Spadea, MD, and Roberto Secondi, MD

Section III      Corneal Cross-Linking Protocols and Complication Management

Chapter 14          The Standard Protocol and Its Parameters

                             Maria A. Woodward, MD, MS; David L. DeMill, MD; Francis W. Price Jr, MD; and

                             Marianne O. Price, PhD, MBA

Chapter 15          Corneal Cross-Linking Using Accelerated Protocols

                             George D. Kymionis, MD, PhD; Konstantinos I. Tsoulnaras, MD; and
                             Chrysanthi Koutsandrea, MD, PhD

Chapter 16          Epithelium-On Protocols: Conceptual/Basic Science

                             Eberhard Spoerl, PhD, and Suphi Taneri, MD

Chapter 17          Transepithelial Corneal Cross-Linking in Progressive Keratoconus

                             Frederik Raiskup, MD, PhD, FEBO

Chapter 18          Corneal Cross-Linking With Iontophoresis

                            Paolo Vinciguerra, MD; Riccardo Vinciguerra, MD; Fabrizio Camesasca, MD; Vito Romano, MD;
                             and Pietro Rosetta, MD

Chapter 19          Cross-Linking Protocols in Thin Corneas

                             Soosan Jacob, MS, FRCS, DNB, and Amar Agarwal, MS, FRCS, FRCOphth

Chapter 20          Pediatric Corneal Cross-Linking

                             Joseph Frucht-Pery, MD, and Denise Wajnsztajn, MD

Chapter 21          Corneal Cross-Linking Complications and Management

                             Karolinne Maia Rocha, MD, PhD; Koray Gümüs, MD, FEBOphth; and J. Bradley Randleman, MD

Section IV      Corneal Cross-Linking Imaging and Diagnostic Evaluations

Chapter 22          Measuring the Efficacy of Corneal Cross-Linking Using Advanced Corneal
                             Biomechanical Diagnostic Modalities

                             Renato Ambrósio Jr, MD, PhD; Marcella Q. Salomão, MD; and Cynthia Roberts, PhD

Chapter 23          Measuring the Efficacy of Cross-Linking: Clinical Metrics

                             J. Bradley Randleman, MD, and Praneetha Thulasi, MD

Chapter 24          Measuring Corneal Cross-Linking Efficacy: Biomechanical Measurement Approach

                             Giuliano Scarcelli; Seok Hyun Yun; and J. Bradley Randleman, MD

Chapter 25          Confocal Microscopy in Corneal Cross-Linking

                            Cosimo Mazzotta, MD, PhD, and Luigi Fontana, MD, PhD

Chapter 26          Optical Coherence Tomography Use in Corneal Cross-Linking

                             Sumitra S. Khandelwal, MD, and J. Bradley Randleman, MD

Chapter 27          Epithelial Remodeling After Corneal Cross-Linking

                             Karolinne Maia Rocha, MD, PhD, and Sudeep Dilip Sunthankar, MD

Section V        Cross-Linking Plus: Combination Procedures

Chapter 28          Corneal Cross-Linking in Combination With Transepithelial Phototherapeutic Keratectomy:
                             Cretan Protocol

                            George D. Kymionis, MD, PhD; Michael A. Grentzelos, MD;
                             and Chrysanthi Koutsandrea, MD, PhD

Chapter 29          Corneal Cross-Linking in Combination With Surface Ablation: Athens Protocol

                             Anastasios John Kanellopoulos, MD, and George Asimellis, PhD

Chapter 30          Corneal Cross-Linking in Combination With Intracorneal Ring Segment

                            Aylin Kiliç, MD, and David Touboul, MD

Chapter 31          Corneal Cross-Linking in Combination With Phakic Intraocular Lenses

                             Jose L. Güell, MD, PhD; Merce Morral, MD, PhD; Emilio J. Segovia, MD; Oscar Gris, MD, PhD;
                             Daniel Elies, MD; and Felicidad Manero, MD

Chapter 32          Corneal Cross-Linking: Combined Treatment Options

                             Efekan Coskunseven, MD, and Onurcan Sahin, MSc

Chapter 33          Corneal Cross-Linking as a Primary Refractive Procedure

                            George D. Kymionis, MD, PhD; Dimitra M. Portaliou, MD, PhD, FEBO; Michael A. Grentzelos, MD;
                             and Chrysanthi Koutsandrea, MD, PhD

Section VI      Cross-Linking for Infectious Keratitis: PACK-CXL

Chapter 34          PACK-CXL

                             Jes Mortensen, MD, and Karim Makdoumi, MD, PhD

Chapter 35          PACK-CXL for Viral Keratitis and Acanthamoeba Keratitis

                             Francis W. Price Jr, MD, and Marianne O. Price, PhD, MBA 

Section VII    Other Uses for Cross-Linking

Chapter 36          Corneal Cross-Linking for Corneal Stromal Edema

                             Niels Ehlers, MD, PhD, and Jesper Hjortdal, MD, PhD

Chapter 37          Sclera Cross-Linking

                             Brendan Geraghty, BEng(Hons), MSc, PhD, and Ahmed Elsheikh, BEng(Hon), MSc, PhD

Section VIII   Current Controversies and Perspectives

Chapter 38          Epithelium-On Treatments

                             In Favor

                             Steven E. Wilson, MD, and Andre A.M. Torricelli, MD, PhD

                             Opposed

                             Aldo Caporossi, MD, PhD, FRCS; Antonio Villano, MD; Stefano Baiocchi, MD, PhD;
                             and Orsola Caporossi, MD, PhD

Chapter 39          Corneal Cross-Linking Can Impact Limbal Stem Cells

                             In Favor

                             Johnny E. Moore, FRCOphth, PhD; David Schiroli, PhD; and C.B. Tara Moore, PhD

                             Opposed

                             Farhad Hafezi, MD, PhD, and Sabine Kling, PhD

Chapter 40          Performing Corneal Cross-Linking After Definitive Signs of
                             Ectasia Progression Are Detected

                             Renato Ambrósio Jr, MD, PhD; Rosane de Oliveira Corrêa, MD;
                             and Rozalia Litewski Beildeck, MD

Chapter 41          Prophylactic Cross-Linking Combined With LASIK

                             In Favor

                            Anastasios John Kanellopoulos, MD, and George Asimellis, PhD

                             Opposed

                             Theo Seiler, MD, PhD

Chapter 42          Summary of Commercially Available Corneal Cross-Linking Units

                             George O. Waring IV, MD, FACS; Susannah L. Brown, MD;
                             and Frederik Raiskup, MD, PhD, FEBO

Financial Disclosures

Index

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