Current Topics in Developmental Biology

Together with other volumes in this series, Volume 58 presents thoughtful and forward-looking articles on developmental biology and developmental medicine. Reviews include: * A role for endogenous electric fields in wound healing * The role of mitotic checkpoint in maintaining genomic stability * The regulation of oocyte maturation * Stem cells: A promising source of pancreatic islets for transplantation in type 1 diabetes * Differentiation potential of adipose derived adult stem (ASAS) cells The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development.

Contributors

ix

Preface

xi

1 A Role for Endogenous Electric Fields in Wound Healing

Richard Nuccitelli

I. Introduction

2

(2)

II. Endogenous Electric Fields Measured near Wounds

4

(3)

III. Epithelial Cells Exhibiting Galvanotaxis

7

(4)

IV. How Do Motile Cells Sense and Respond to the Imposed Electric Field?

11

(3)

V. Can Imposed Electric Fields be used to Stimulate Wound Healing?

14

(5)

VI. Clinical Trials Using Electric Fields to Stimulate Wound Healing

19

(1)

VII. Summary

20

(1)

References

21

(6)

2 The Role of Mitotic Checkpoint in Maintaining Genomic Stability

Song-Tao Liu, Jan M. van Deursen, and Tim J. Yen

I. Introduction

27

(2)

II. The Kinetochore is a Complex Structure for Cell Division

29

(2)

III. The Mitotic Checkpoint

31

(10)

IV. Mutations in Mitotic Checkpoint Proteins and Tumorigenesis

41

(4)

V. Conclusions and Future Directions

45

(3)

Acknowledgments

48

(1)

References

48

(6)

3 The Regulation of Oocyte Maturation

Ekaterina Voronina and Gary M. Wessel

I. Concept of Oocyte Maturation

54

(2)

II. Life and Death of an Oocyte

56

(14)

III. Maturation Promoting Factor

70

(3)

IV. Initiation of Oocyte Maturation

73

(11)

V. Cytoplasmic Control of Maturation

84

(14)

VI. Concluding Remarks

98

(1)

Acknowledgments

99

(1)

References

99

(13)

4 Stem Cells: A Promising Source of Pancreatic Islets for Transplantation in Type 1 Diabetes

Cale N. Street, Ray V. Rajotte, and Gregory S. Korbutt

I. Introduction

112

(1)

II. Islet Transplantation: Success with Limitations

113

(1)

III. Alternative Sources of Transplantable Islets

114

(1)

IV. Differentiation of Embryonic Stem Cells into Insulin-producing Cells

115

(4)

V. Identification of the Elusive Pancreatic Stem Cell

119

(7)

VI. Existence of Nonpancreatic Islet Progenitor Cells

126

(2)

VII. Summary

128

(1)

References

129

(8)

5 Differentiation Potential of Adipose Derived Adult Stem (ADAS) Cells

Jeffrey M. Gimble and Farshid Guilak

I. Introduction

137

(1)

II. Adipose Tissue-Physiology

138

(4)

III. Adipose Tissue Pathology

142

(2)

IV. Adipose Derived Adult Stem (ADAS)

144

(2)

V. ADAS Cell Differentiation Potential and Potential Therapeutic Applications

146

(5)

VI. Functional Tissue Engineering Considerations

151

(2)

VII. Conclusions and Future Directions

153

(1)

Acknowledgments

153

(1)

References

154

(7)

Index

161

(6)

Contents of Previous Volumes

167

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Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

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5% off 1 book, 7% off 2 books, 10% off 3+ books

Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

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