Current Topics in Developmental Biology

In keeping with the tradition of excellence of past volumes of the Current Topics in Developmental Biology series, this volume provides a comprehensive survey of major issues at the forefront of modern developmental biology and regenerative medicine. Astonishing discoveries are presented in thoughtful and forward-looking articles.

Contributors

ix

Preface

xi

1 Hepatic Oval Cells: Helping Redefine a Paradigm in Stem Cell Biology

P.N. Newsome, M.A. Hussain, and N.D. Theise

I. Hepatic Stem Cells: Characterization and Localization

2

(5)

II. Hepatic Stem Cells: Origin and Function

7

(2)

III. Extrahepatic Stem Cells: A Paradigm Shift

9

(3)

IV. Controversies

12

(6)

V. Hypotheses/Mechanisms

18

(3)

VI. The Future

21

(1)

References

22

(8)

2 Meiotic DNA Replication

Randy Strich

I. Introduction

30

(2)

II. General Features of Meiotic S Phase

32

(1)

III. Initiation of Premeiotic S Phase

33

(3)

IV. meiS Phase Progression

36

(4)

V. Meiosis-Specific Replication Factors

40

(2)

VI. Fidelity of DNA Replication

42

(1)

VII. Role of Replication for Subsequent Meiotic Events

43

(6)

VIII. Block to Meiotic Rereplication

49

(3)

IX. Conclusions

52

(1)

Acknowledgments

52

(1)

References

52

(9)

3 Pollen Tube Guidance: The Role of Adhesion and Chemotropic Molecules

Sunran Kim, Juan Dong, and Elizabeth M. Lord

I. Introduction

61

(3)

II. Adhesion and Chemotropism

64

(5)

III. Chemocyanin: A Chemotropic Peptide in the Lily Stigma

69

(6)

IV. Outlook

75

(1)

References

76

(6)

4 The Biology and Diagnostic Applications of Fetal DNA and RNA in Maternal Plasma

Rossa W.K. Chiu and Y.M. Dennis Lo

I. Introduction

82

(2)

II. Biology of Circulating Fetal Nucleic Acids

84

(4)

III. Diagnostic Applications of Fetal DNA Analysis in Maternal Plasma

88

(4)

IV. Fetal RNA in Maternal Plasma: A New Avenue to Noninvasive Prenatal Diagnosis

92

(2)

V. Preanalytical and Technical Issues on Fetal Nucleic Acids Analysis from Maternal Plasma

94

(7)

VI. Fetal Nucleic Acids Analysis: The Way Forward

101

(1)

Acknowledgments

102

(1)

References

102

(11)

5 Advances in Tissue Engineering

Shulamit Levenberg and Robert Langer

I. Background on Tissue Engineering

113

(3)

II. Role of Scaffolds in Tissue Engineering

116

(2)

III. Using Progenitor and Stem Cells in Tissue Engineering

118

(4)

IV. Vascularization of Engineered Tissue Constructs

122

(2)

V. Tissue Engineering as an In Vitro Model for Cell Differentiation and Organogenesis

124

(1)

References

124

(11)

6 Directions in Cell Migration Along the Rostral Migratory Stream: The Pathway for Migration in the Brain

Shin-ichi Murase and Alan F. Horwitz

I. Introduction

135

(3)

II. The Nature of Migration in the Rostra) Migratory Stream

138

(1)

IIL PSA-N-CAM in Chain Migrations

139

(3)

IV. Other Mechanisms Mediating Migration

142

(2)

V. Mechanisms for Directional Navigation

144

(1)

VI. Regulation of Differentiation into Mature Neurons

145

(3)

VII. Summary

148

(1)

Acknowledgment

148

(1)

References

148

(6)

7 Retinoids in Lung Development and Regeneration

Malcolm Maden

I. Stages of Lung Development

154

(6)

II. What is Retinoic Acid (RA)

160

(1)

III. RA is Required for Budding of the Foregut Tube

161

(3)

IV. Branching Morphogenesis is Inhibited by RA

164

(5)

V. RA is Required during the End of the Foetal Period (Pseudoglandular, Canalicular, and Terminal Saccule Stages)

169

(3)

VI. RA is Required for Postnatal Septation (Alveologenesis)

172

(3)

VII. RA Induces Alveolar Regeneration

175

(4)

VIII. Speculations of the Mode of Action of RA

179

(1)

IX. Clinical Implications and Future Possibilities

180

(1)

Acknowledgment

181

(1)

References

181

(11)

8 Structural Organization and Functions of the Nucleus in Development, Aging, and Disease

Leslie Mounkes and Colin L. Stewart

I. Introduction

192

(1)

II. The Nuclear Envelope (NE) and Lamina

193

(2)

III. Protein Components of the NE

195

(2)

IV. Functions of Lamins

197

(4)

V. Lamins and the NE in Development

201

(4)

VI. Envelopathies and Laminopathies

205

(6)

VII. Disease Mechanisms

211

(5)

VIII. Conclusions

216

(1)

References

217

(12)

Index

229

(8)

Contents of Previous Volumes

237

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Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

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Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

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