Current Topics in Developmental Biology

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. This volume contains six important contributions from leading minds in developmental biology. * Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells, cloning, and regenerative medicine * Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science * The longest-running forum for current issues in developmental biology with over 30 years of coverage

Contributors

ix

Preface

xi

1 Early Events in the DNA Damage Response

Irene Ward and Junjie Chen

I. Introduction

1

(3)

II. Formation of Multiprotein Complexes

4

(17)

III. Concluding Remarks

21

(1)

Acknowledgments

22

(1)

References

22

(15)

2 Afrotherian Origins and Interrelationships: New Views and Future Prospects

Terence J. Robinson and Erik R. Seiffert

I. Introduction

37

(3)

II. Morphological and Molecular Evidence

40

(4)

III. Continental Drift, Cladistic Biogeography, and Afrotherian Origins

44

(5)

IV. Rare Genomic Changes

49

(3)

V. Conclusions

52

(2)

References

54

(7)

3 The Role of Antisense Transcription in the Regulation of X-Inactivation

Claire Rougeulle and Philip Avner

I. Introduction

61

(5)

II. Early Signs of Antisense Transcription within Xist

66

(2)

III. Is There One Xist Antisense Transcript or Several?

68

(1)

IV. Tsix Is Involved in Imprinted X-Inactivation

69

(2)

V. Tsix Is Involved in Neither Counting nor Silencing

71

(1)

VI. Is Tsix Involved in Choice?

72

(2)

VII. A Role for Tsix in Xist Metabolism

74

(2)

VIII. Mechanistic Insights into Tsix Function

76

(4)

IX. Regulation of Tsix Transcription

80

(2)

X. Is Tsix Functional Only in the Mouse?

82

(1)

XI. Concluding Remarks

82

(3)

References

85

(6)

4 The Genetics of Hiding the Corpse: Engulfment and Degradation of Apoptotic Cells in C. elegans and D. melanogaster

Zheng Zhou, Paolo M. Mangahas, and Xiaomeng Yu

I. Introduction

91

(3)

II. Studies of Cell Corpse Engulfment in C. elegans

94

(27)

III. The Degradation of Nuclear DNA During Programmed Cell Death in C. elegans

121

(5)

IV. Study of Engulfment and DNA Degradation in Drosophila

126

(9)

V. Concluding Remarks

135

(1)

Acknowledgments

136

(1)

References

136

(10)

5 Beginning and Ending an Actin Filament: Control at the Barbed End

Sally H. Zigmond

I. Introduction

146

(2)

II. Locally Create a Free Barbed End

148

(19)

III. Enhance Barbed-End Elongation

167

(1)

IV. Capping Barbed Ends

168

(7)

V. Replenish G-Actin Pool by Pointed-End Depolymerization of F-Actin

175

(1)

VI. New Directions

176

(1)

References

177

(13)

6 Life Extension in the Dwarf Mouse

Andrzej Bartke and Holly Brown-Borg

I. Introduction

190

(1)

II. Origin and Phenotypic Characteristics of Mutant, Knockout, and Transgenic Dwarf Mice

191

(5)

III. Longevity of Different Types of Dwarf Mice

196

(4)

IV. Suspected Mechanisms of Prolonged Longevity

200

(8)

V. Why Are Dwarf Mice Long-Lived? Single versus Multiple Mechanisms

208

(2)

VI. How Do the Findings in Long-Lived Mutant Mice Fit into the "Big Picture"? What Can Be Extrapolated to Genetically Normal Mice and to Other Species?

210

(4)

VII. Breeding and Husbandry of Long-Lived Mutant Mice

214

(1)

References

215

(12)

Index

227

(10)

Contents of Previous Volumes

237

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Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

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5% off 1 book, 7% off 2 books, 10% off 3+ books

Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

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