Current Topics in Developmental Biology

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. Volume 68, the most recent publication in Current Topics in Developmental Biology, not only discusses the most up-to-date discoveries, it includes 46 figures and 7 tables, all in full color. This volume touches upon topics such as Prolactin and Growth Hormone Signaling; Corpus Luteum Development: Lessons from Genetic Models in Mice; Comparative Developmental Biology of the Mammalian Uterus; Sarcopenia of Aging and its Metabolic Impact; and even a chapter on Initial failure in Myoblast Transplantation Therapy has led the way towards the isolation of muscle stem cells: Potential for tissue regeneration. * Most recent volume series that offers 11 chapters of the latest studies of developmental biology * Discusses various subjects such as tissue regeneration, the role of proteins, and a comparative analysis of the mammalian uterus * Full color figures and tables with detailed illustrations

Contributors

xi

1 Prolactin and Growth Hormone Signaling

Beverly Chilton and Aveline Hewetson

I. Introduction

2

(1)

II. Growth Hormone

2

(3)

III. Prolactin

5

(2)

IV. The Jak/Stat Pathway

7

(5)

V. Putative Jak2/RUSH Pathway

12

(3)

VI. Alternatives to Jak/Stat Signaling

15

(1)

VII. Negative Regulators of Jak/Stat

15

(2)

VIII. Conclusions

17

(1)

Acknowledgments

18

(1)

References

18

(8)

2 Alterations in cAMP-Mediated Signaling and Their Role in the Pathophysiology of Dilated Cardiomyopathy

Matthew A. Movsesian and Michael R. Bristow

I. Introduction

26

(1)

II. cAMP-Mediated Signaling in Dilated Cardiomyopathy

27

(3)

III. What Inferences Can be Drawn from Clinical Studies?

30

(1)

IV. Probing More Deeply in Transgenic Animals

31

(1)

V. Evidence that Attenuation of cAMP-Mediated Signaling is Pathogenetic

31

(1)

VI. Evidence that the β-Adrenergic Receptor-Mediated Signaling Changes Are Compensatory

32

(1)

VII. Inferences from Studies in Transgenic Animals

33

(1)

VIII. The Compartmentation of cAMP-Mediated Signaling in Cardiac Myocytes

34

(2)

IX. Evidence for the Potential Benefits of Increasing the Phosphorylation of Individual PK-A Substrates

36

(1)

X. The Compartmentation of cAMP-Mediated Signaling in Dilated Cardiomyopathy in Humans

37

(1)

XI. Implications

38

(3)

Acknowledgments

41

(1)

References

41

(9)

3 Corpus Luteum Development: Lessons from Genetic Models in Mice

Anne Bachelot and Nadine Binart

I. Introduction

50

(1)

II. Development of the Corpus Luteum

50

(11)

III. Luteolysis

61

(5)

IV. Factors Affecting the Maintenance or the Development of the Corpus Luteum: Mouse Models

66

(12)

V. Conclusion

78

(1)

References

79

(7)

4 Comparative Developmental Biology of the Mammalian Uterus

Thomas E. Spencer, Kanako Hayashi, Jianbo Hu, and Karen D. Carpenter

I. Introduction

86

(1)

II. Development of the Mullerian Duct and Uterus

86

(5)

III. Comparative Development of the Uterus

91

(5)

IV. Mechanisms Regulating Prenatal Development of the Müllerian Duct

96

(5)

V. Mechanisms Regulating Postnatal Development of the Uterus

101

(10)

VI. Developmental Disruption

111

(2)

VII. Summary

113

(1)

References

114

(10)

5 Sarcopenia of Aging and Its Metabolic Impact

Helen Karakelides and K. Sreekumaran Nair

I. Introduction

124

(1)

II. What Is Aging?

125

(1)

III. Age-Related Muscle Changes in Humans

125

(13)

IV. Aging Muscle and Hormones

138

(4)

V. Summary

142

(1)

References

143

(7)

6 Chemokine Receptor CXCR3: An Unexpected Enigma

Liping Liu, Melissa K. Callahan, DeRen Huang, and Richard M. Ransohoff

I. Introduction to Chemokines and Chemokine Receptors

150

(1)

II. Cloning, Characterization, and Regulation of CXCR3 and Its Ligands

151

(6)

III. CXCR3: Roles in T-Cell Chemotaxis and Effector Functions

157

(2)

IV. Introduction to CNS Inflammatory/Autoimmune Disorders and Corresponding Animal Models

159

(2)

V. Complex Roles of CXCR3 and Its Ligands in Diverse Disease Models

161

(9)

VI. The Role of CXCR3 and Its Ligands in CNS Inflammatory/Autoimmune Disorders

170

(3)

VII. Concluding Remarks

173

(1)

Acknowledgments

173

(1)

References

174

(10)

7 Assembly and Signaling of Adhesion Complexes

Jorge L. Sepulveda, Vasiliki Gkretsi, and Chuanyue Wu

I. Introduction

184

(1)

II. Integrin-Mediated Cell-ECM Adhesion

184

(2)

III. The PINCH-ILK-Parvin Complexes

186

(9)

IV. Adhesion Complexes in Cardiac Myocytes

195

(15)

Acknowledgments

210

(1)

References

210

(18)

8 Signaling Mechanisms of Higher Plant Photoreceptors: A Structure-Function Perspective

Haiyang Wang

I. Introduction

228

(1)

II. Phytochromes

229

(7)

III. Cryptochromes

236

(7)

IV. Phototropins

243

(6)

V. Other Plant Photoreceptors

249

(1)

VI. Concluding Remarks

250

(1)

Acknowledgments

251

(1)

References

251

(13)

9 Initial Failure in Myoblast Transplantation Therapy Has Led the Way Toward the Isolation of Muscle Stem Cells: Potential for Tissue Regeneration

Kenneth Urish, Yasunari Kanda, and Johnny Huard

I. Introduction

264

(1)

II. Myoblast Transplantation

264

(1)

III. Initial Limitations of Transplantation

265

(2)

IV. Improved Skeletal Muscle Regeneration

267

(2)

V. Mechanism of Improved Muscle Regeneration

269

(3)

VI. MDSCs and the Development of Muscle

272

(2)

VII. Tissue Engineering and MDSCs

274

(1)

References

275

(7)

10 Role of 14-3-3 Proteins in Eukaryotic Signaling and Development

Dawn L. Darling, Jessica Yingling, and Anthony Wynshaw-Boris

I. 14-3-3 Introduction

282

(3)

II. 14-3-3 in Yeast Development

285

(4)

III. 14-3-3 in Plant Development

289

(3)

IV. Role of 14-3-3 in Drosophila Development

292

(7)

V. Role of 14-3-3 in Xenopus Development

299

(2)

VI. Role of 14-3-3 in Mammalian Development

301

(4)

VII. 14-3-3 in Human Development

305

(1)

VIII. Summary

306

(1)

References

306

(12)

11 The Evolution and Function of Blue and Red Light Photoreceptors

Angela Falciatore and Chris Bowler

I. Introduction

318

(1)

II. Blue Light Perception and Signaling

319

(15)

III. Red Light Perception and Signaling

334

(10)

IV. Concluding Remarks

344

(1)

Acknowledgments

345

(1)

References

345

(6)

Index

351

(16)

Contents of Previous Volumes

367

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Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Current Topics in Developmental Biology

Summary

Table of Contents

Supplemental Materials

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