Current Topics in Developmental Biology

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ISBN: 9780121531720 | 0121531724
Cover: Hardcover
Copyright: 3/17/2006

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In keeping with the tradition of excellence of past volumes of the Current Topics in Developmental Biology series, this volume provides a comprehensive survey of major issues at the forefront of modern developmental biology and regenerative medicine. Astonishing discoveries are presented in thoughtful and forward-looking articles.

Contributors	p. ix
Contribution of Membrane Mucins to Tumor Progression Through Modulation of Cellular Growth Signaling Pathways
Mucin Structure, Function, and Involvement in Tumor Progression	p. 2
MUC1 Contributions to Tumor Cell Growth Signaling	p. 5
MUC4 Contributions to Tumor Cell Growth Signaling	p. 10
Inhibition of Signaling by Mucins	p. 14
Perspectives	p. 15
References	p. 16
Regulation of the Epithelial Na[superscript +] Channel by Peptidases
Introduction	p. 24
ENaC Regulation by Peptidases: In Vitro and Biochemical Evidence	p. 25
ENaC Regulation by Peptidases: In Vitro Evidence	p. 31
References	p. 41
Advances in Defining Regulators of Cementum Development and Periodontal Regeneration
Introduction	p. 48
Question 1. What Are the Unknowns That Must Be Considered in Order to Replicate the Enamel (Crown) and How Do the Proteins Involved in Crown Development Relate to Root Development?	p. 51
Question 2. What Do We Know About the Cells Required for Periodontal Development and Regeneration?	p. 63
Question 3. What Genes and Associated Proteins Are Important for Root/Periodontal Tissue Formation?	p. 76
Conclusions and Future Directions	p. 101
Acknowledgments	p. 103
References	p. 103
Anabolic Agents and the Bone Morphogenetic Protein Pathway
Introduction	p. 128
Bone Metabolism	p. 131
The BMP Pathway and Bone Anabolic Therapies	p. 135
Conclusions and Future Directions	p. 153
References	p. 154
The Role of Mammalian Circadian Proteins in Normal Physiology and Genotoxic Stress Responses
Introduction	p. 174
Circadian Rhythms and the Organization of the Mammalian Circadian System	p. 175
Molecular Organization of the Circadian Oscillator in Mammals	p. 176
Human Disorders Associated with Altered Function of the Circadian System	p. 185
Pathologies and Developmental Defects in Circadian Mutant Mice	p. 190
Circadian Control of the Organism's Response to Genotoxic Stress	p. 200
Circadian Proteins as Targets for Therapeutic Intervention	p. 207
Acknowledgments	p. 207
References	p. 207
Autophagy and Cell Death
Introduction	p. 218
Description of Programed Cell Death Morphologies	p. 218
Autophagic Cell Death	p. 219
Autophagy and Autophagic Cell Death Regulatory Mechanisms	p. 222
Autophagy-Apoptosis Crosstalks	p. 234
Survival Versus Death Aspects of Autophagy	p. 236
Conclusions	p. 237
Acknowledgments	p. 238
References	p. 238
Index	p. 247
Contents of Previous Volumes	p. 255
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Current Topics in Developmental Biology

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