Cutaneous Lymphomas

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ISBN: 9780824729974 | 0824729978
Cover: Hardcover
Copyright: 5/26/2005

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Based on extensive clinical, histological, and experimental studies, this guide serves as an authoritative source of information on the epidemiology, etiology, pathogenesis, diagnosis, and treatment of cutaneous lymphomas-reflecting the state-of-the-art in the field of cutaneous lymphomas-presented in the context of the brand-new WHO/EORTC-consensus-classification.

Preface

xxi

Contributors

xxiii

Abbreviations

xxv

Introduction

Cutaneous Lymphomas---Historical Aspects

(6)

Michael Geiges

Roman Specker

Werner Kempf

Gunter Burg

Unique Features of Cutaneous Lymphomas

(4)

Gunter Burg

Werner Kempf

Cutaneous Lymphoma: A Prototype Neoplasia for Cancer Research

(2)

Gunter Burg

Werner Kempf

Epidemiology

(8)

Gunter Burg

Werner Kempf

Cutaneous Lymphomas

(1)

Cutaneous T-cell Lymphomas

(3)

Epidemiologic Factors Influencing Incidence and Mortality Rates

(1)

Cutaneous B-cell Lymphomas (CBCL)

(4)

STRUCTURE AND FUNCTION OF THE LYMPHOID SYSTEM

The Lymphoid System

(2)

Marshall E. Kadin

Structure and Function of Secondary Lymphoid Tissues

(6)

Marshall E. Kadin

Spleen

(1)

Mucosa-Associated Lymphoid Tissues

(1)

Skin

(1)

Ontogeny of Lymphoid Cells

(8)

Marshall E. Kadin

B-cell Ontogeny

(1)

T-cell Ontogeny

(1)

γ/δ T-cells

(1)

Natural Killer Cells

(1)

Myeloid Cells

(1)

Eosinophils

(1)

Basophils and Mast Cells

(1)

Monocytes and Macrophages

(4)

Histo- and Cytomorphology

(2)

Marshall E. Kadin

Growth Patterns of Lympho- and Myeloproliferative Infiltrates of the Skin

(6)

Gunter Burg

Marshall E. Kadin

Werner Kempf

Principal Growth Pattern

(1)

Growth Pattern in Cutaneous Lymphomas

(3)

Growth Patterns of Myeloproliferative Infiltrates in the Skin

(2)

DIAGNOSTIC APPROACH TO CUTANEOUS LYMPHOMAS

Stepwise Approach to the Diagnosis of Lymphoproliferative Skin Infiltrates and Related Disorders

(4)

Monika Hess Schmid

Gunter Burg

Werner Kempf

History

(1)

Clinical Features

(4)

Clinical Staging of Cutaneous Lymphomas

(4)

Monika Hess Schmid

Gunter Burg

Sonja Michaelis

Werner Kempf

Classical Alibert--Bazin Staging

(1)

TNM Staging

(1)

Tumor Burden Index

(3)

Laboratory Investigations

(4)

Monika Hess Schmid

Gunter Burg

Werner Kempf

Skin Biopsies

(1)

Lymph Node and Bone Marrow Biopsies

(1)

Blood Tests

(1)

Radiologic Tests

(3)

Immunohistochemistry and Phenotypic Features

(8)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Introduction

(1)

Technical Aspects of Immunophenotyping in Cutaneous Lymphomas

(1)

A Practical Stepwise Approach to Cutaneous Lymphomas

(1)

CTCL and Cytotoxic Lymphomas

(1)

CD30-Positive Lymphoproliferative Diseases

(2)

CBCL and B-cell Pseudolymphoma

(2)

Leukemic Infiltrates of the Skin

(1)

Immunophenotypic Markers as Prognostic Parameters

(2)

Genotyping

(4)

Udo Doebbeling

Werner Kempf

Antonio Cozzio

Reinhard Dummer

Gunter Burg

The Identification of a Malignant T-cell Clone by PCR-DGGE

(1)

Advantages and Limitations of PCR-DGGE

(2)

Cytogenetic Studies in Cutaneous Lymphomas

(4)

Werner Kempf

Antonio Cozzio

Dmitry V. Kazakov

Gunter Burg

Introduction

(1)

Genetic Abnormalities in Cutaneous T-cell Lymphomas

(1)

Genetic Abnormalities in Cutaneous B-cell Lymphomas

(1)

Conclusions

(2)

Functional Profiling by Microarray Technology

(6)

Antonio Cozzio

Werner Kempf

Reinhard Dummer

Gunter Burg

Types of Microarray Experiments

(1)

DNA Microarray Experiments

(1)

Protein-Based Gene Expression Analysis

(1)

Cutaneous Lymphoma

(3)

Classification of Nodal Lymphomas in Historical Perspective

(4)

Marshall E. Kadin

Revised European--American (REAL) Classification

(1)

World Health Organization (WHO) Classification of Hematologic Malignancies

(1)

Classification of Cutaneous Lymphomas in Historical Perspective

(8)

Christian A. Sander

Michael J. Flaig

Werner Kempf

Gunter Burg

WHO/EORTC Classification of Cutaneous Lymphomas

(4)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Sonja Michaelis

Reinhard Dummer

Prognostic Categorization of Lymphoproliferative Disorders of the Skin: A New and Clinically Oriented Approach

(6)

Gunter Burg

Sonja Michaelis

Philippa Golling

Werner Kempf

Prognostic Categories

(6)

CUTANEOUS T-CELL AND NK-CELL LYMPHOMAS

Mycosis Fungoides

101

(16)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

101

(1)

Definition

101

(1)

Clinical Features

101

(3)

Histology

104

(1)

Immunohistochemistry

105

(1)

Molecular Biology

106

(1)

Cytogenetic Analysis

107

(1)

Treatment

107

(1)

Clinical Course and Prognosis

107

(1)

Differential Diagnosis

108

(1)

Comments

109

(1)

Mycosis Fungoides in Childhood and Adolescence

109

(1)

Clinical Features

109

(1)

Histology

109

(1)

Immunohistochemistry

109

(1)

Molecular Biology

109

(1)

Treatment

109

(1)

Clinical Course and Prognosis

110

(1)

Differential Diagnosis

110

(1)

Comments

110

(3)

Transformation of CTCL

113

(4)

Werner Kempf

Dmitry V. Kazakov

Sonja Michaelis

Gunter Burg

Definition

113

(1)

Clinical Features

113

(1)

Histology

113

(2)

Immunohistochemistry

115

(1)

Treatment

115

(1)

Clinical Course and Prognosis

115

(1)

Differential Diagnosis

116

(1)

Variants and Subtypes of Mycosis Fungoides

117

(22)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Pagetoid Reticulosis

117

(6)

Classification

117

(1)

Definition

117

(1)

Clinical Features

118

(1)

Histology

118

(1)

Immunohistochemistry

119

(1)

Molecular Biology

120

(1)

Treatment

120

(1)

Clinical Course and Prognosis

120

(1)

Differential Diagnosis

120

(1)

Comments

121

(2)

Syringotropic Cutaneous T-cell Lymphoma

123

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

123

(1)

Definition

123

(1)

Clinical Features

123

(1)

Histology

123

(1)

Immunohistochemistry

124

(1)

Molecular Biology

125

(1)

Treatment

125

(1)

Clinical Course and Prognosis

125

(1)

Differential Diagnosis

125

(1)

Comments

125

(2)

Other Variants of Mycosis Fungoides

127

(12)

Dmitry V. Kazakov

Werner Kempf

Gunter Burg

Granulomatous Cutaneous T-cell Lymphomas

139

(14)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Granulomatous Variants of CTCL

139

(1)

Histology

139

(1)

Immunohistochemistry

139

(1)

Treatment

140

(1)

Clinical Course and Prognosis

140

(1)

Differential Diagnosis

140

(1)

Comments

140

(3)

Granulomatous Slack Skin

143

(6)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

143

(1)

Definition

143

(1)

Clinical Features

143

(2)

Histology

145

(1)

Immunohistochemistry

146

(1)

Molecular Biology

146

(1)

Treatment

146

(1)

Clinical Course and Prognosis

146

(1)

Differential Diagnosis

147

(1)

Comments

147

(2)

Juvenile Granulomatous Cutaneous T-cell Lymphoma

149

(4)

Werner Kempf

Gunter Burg

Classification

149

(1)

Definition

149

(1)

Clinical Features

149

(1)

Histology

150

(1)

Immunohistochemistry

151

(1)

Treatment

151

(1)

Clinical Course and Prognosis

151

(1)

Differential Diagnosis

151

(1)

Comments

151

(2)

Sezary Syndrome (SS)

153

(10)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

153

(1)

Definition

153

(1)

Clinical Features

154

(1)

Histology

155

(2)

Immunohistochemistry

157

(1)

Molecular Biology

158

(1)

Diagnosis

158

(1)

Treatment

159

(1)

Clinical Course and Prognosis

159

(1)

Differential Diagnosis

159

(1)

Comments

159

(4)

CD30+ T-cell Lymphoproliferative Disorders of the Skin

163

(18)

Werner Kempf

Gunter Burg

Lymphomatoid Papulosis

165

(8)

Werner Kempf

Gunter Burg

Dmitry V. Kazakov

Classification

165

(1)

Definition

165

(1)

Clinical Features

165

(2)

Histology

167

(1)

Immunohistochemistry

167

(2)

Molecular Biology

169

(1)

Treatment

170

(1)

Clinical Course and Prognosis

170

(1)

Differential Diagnosis

171

(1)

Comments

171

(2)

Primary Cutaneous Anaplastic Large Cell Lymphoma

173

(8)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification and Terminology

173

(1)

Definition

173

(1)

Clinical Features

174

(1)

Histology

174

(1)

Immunohistochemistry

175

(1)

Molecular Biology

176

(1)

Treatment

176

(1)

Clinical Course and Prognosis

176

(1)

Differential Diagnosis

177

(1)

Comments

177

(4)

Subcutaneous Panniculitis-like T-cell Lymphoma

181

(6)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

181

(1)

Definition

181

(1)

Clinical Features

181

(1)

Histology

181

(1)

Immunohistochemistry

182

(1)

Treatment

183

(1)

Clinical Course and Prognosis

184

(1)

Differential Diagnosis

184

(1)

Comments

184

(3)

Primary Cutaneous Peripheral T-cell Lymphoma, Unspecified

187

(18)

Werner Kempf

Dmitry V. Kazakov

Reinhard Dummer

Gunter Burg

Cytotoxic Lymphomas

187

(10)

Cytotoxic Molecules

188

(1)

CD8+ Cytotoxic Cutaneous T-cell Lymphomas

189

(1)

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Gunter Burg

MF-Like Hypo- or Hyperpigmented Form of Cytotoxic CD8+ T-cell Lymphoma

189

(2)

Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma

191

(1)

Nodular Form of Cytotoxic CD8+ CTCL

192

(3)

Cutaneous Gamma/Delta T-cell Lymphoma

195

(1)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

195

(1)

Definition

195

(1)

Clinical Features

195

(1)

Histology

195

(1)

Immunohistochemistry

196

(1)

Molecular Biology

196

(1)

Treatment

196

(1)

Clinical Course and Prognosis

196

(1)

Differential Diagnosis

196

(1)

Primary Cutaneous Peripheral T-cell Lymphoma, Unspecified Noncytotoxic Variants

197

(8)

Primary Cutaneous CD4-Positive Small- to Medium-Sized Pleomorphic T-cell Lymphoma

197

(1)

Classification

197

(1)

Definition

197

(1)

Clinical Features

197

(1)

Histology

198

(1)

Immunohistochemistry

198

(1)

Molecular Biology

199

(1)

Treatment

199

(1)

Clinical Course and Prognosis

199

(1)

Differential Diagnosis

199

(2)

Primary Cutaneous Peripheral T-cell Lymphomas, Unspecified, Other Forms

201

(1)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

201

(1)

Definition

201

(1)

Histopathology

202

(1)

Immunohistochemistry

202

(1)

Molecular Biology

202

(1)

Treatment

202

(1)

Clinical Course and Prognosis

202

(1)

Differential Diagnosis

202

(1)

Comments

203

(2)

Extranodal NK/T-cell Lymphoma, Nasal Type

205

(10)

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Gunter Burg

Classification

205

(1)

Definition

205

(1)

Clinical Features

205

(1)

Histology

206

(1)

Immunohistochemistry

206

(1)

Molecular Biology

206

(1)

Treatment

206

(1)

Clinical Course and Prognosis

206

(3)

Hydroa-like Lymphoma

209

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

209

(1)

Definition

209

(1)

Clinical Features

209

(1)

Histology

210

(1)

Immunohistochemistry

211

(1)

Molecular Biology

211

(1)

Treatment

211

(1)

Clinical Course and Prognosis

211

(1)

Differential Diagnosis

211

(1)

Comments

212

(3)

Adult T-cell Leukemia/Lymphoma

215

(6)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

215

(1)

Definition

215

(1)

Clinical Features

215

(1)

Histology

215

(2)

Immunohistochemistry

217

(1)

Molecular Biology

217

(1)

Treatment

217

(1)

Course and Prognosis

217

(1)

Differential Diagnosis

218

(3)

Cutaneous Manifestations in Other Mature T-cell Neoplasms

221

(10)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Angioimmunoblastic T-cell Lymphoma

221

(4)

Classification

221

(1)

Definition

221

(1)

Clinical Features

221

(1)

Histology

222

(1)

Immunohistochemistry

223

(1)

Molecular Biology

223

(1)

Treatment

223

(1)

Clinical Course and Prognosis

223

(1)

Differential Diagnosis

224

(1)

Comments

224

(1)

T-Zone Lymphoma

225

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

225

(1)

Definition

225

(1)

Clinical Features

225

(1)

Histology

226

(1)

Immunohistochemistry

226

(1)

Molecular Biology

227

(1)

Treatment

227

(1)

Clinical Course and Prognosis

227

(1)

Differential Diagnosis

228

(1)

Comments

228

(3)

CUTANEOUS B-CELL LYMPHOMAS

Primary Cutaneous Marginal Zone B-cell Lymphoma

231

(22)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

231

(1)

Definition

231

(1)

Clinical Features

231

(1)

Histology

232

(1)

Immunohistochemistry

233

(1)

Molecular Biology

233

(1)

Treatment

234

(1)

Clinical Course and Prognosis

234

(1)

Differential Diagnosis

234

(3)

Immunocytoma

237

(6)

Gunter Burg

Werner Kempf

Classification

237

(1)

Definition

237

(1)

Clinical Features

237

(1)

Histology

237

(2)

Immunohistochemistry

239

(1)

Molecular Biology

239

(1)

Treatment

239

(1)

Clinical Course and Prognosis

240

(1)

Differential Diagnosis

240

(3)

Primary Cutaneous Plasmacytoma (PCP)

243

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

243

(1)

Definition

243

(1)

Clinical Features

243

(2)

Histology

245

(1)

Immunohistochemistry

245

(1)

Molecular Biology

245

(1)

Treatment

245

(1)

Clinical Course and Prognosis

245

(1)

Differential Diagnosis

246

(1)

Comments

246

(3)

Cutaneous Follicular Lymphoid Hyperplasia with Monotypic Plasma Cells

249

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

249

(1)

Clinical Features

249

(1)

Histology

249

(1)

Immunohistochemistry

250

(1)

Molecular Biology

250

(1)

Treatment

250

(1)

Clinical Course and Prognosis

250

(1)

Differential Diagnosis

250

(1)

Comments

251

(2)

Primary Cutaneous Follicle Center Lymphoma

253

(6)

Dmitry V. Kazakov

Werner Kempf

Gunter Burg

Classification

253

(1)

Definition

253

(1)

Clinical Features

253

(1)

Histology

253

(2)

Immunohistochemistry

255

(1)

Treatment

255

(1)

Clinical Course and Prognosis

256

(1)

Differential Diagnosis

256

(1)

Comments

256

(3)

Primary Cutaneous Diffuse Large B-cell Lymphoma

259

(10)

Gunter Burg

Werner Kempf

Classification

259

(1)

Definition

259

(1)

Primary Cutaneous Large B-cell Lymphoma, Leg Type

259

(6)

Other Primary Cutaneous Large B-cell Lymphoma

263

(2)

Primary Cutaneous Diffuse Large B-cell Lymphomas, Other: T-cell-Rich B-cell Lymphoma

265

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

265

(1)

Definition

265

(1)

Clinical Features

265

(1)

Histology

266

(1)

Immunohistochemistry

266

(1)

Molecular Biology

267

(1)

Treatment

267

(1)

Clinical Course and Prognosis

268

(1)

Differential Diagnosis

268

(1)

Comments

268

(1)

Intravascular Large B-cell Lymphoma

269

(6)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Classification

269

(1)

Definition

269

(1)

Clinical Features

269

(1)

Histology

270

(1)

Immunohistochemistry

270

(1)

Molecular Biology

271

(1)

Therapy

271

(1)

Clinical Course and Prognosis

271

(1)

Differential Diagnosis

271

(1)

Comments

272

(3)

B-cell Lymphomas with Common Secondary Cutaneous Involvement

275

(18)

Gunter Burg

Werner Kempf

Lymphomatoid Granulomatosis

275

(4)

Classification

275

(1)

Definition

275

(1)

Clinical Features

275

(1)

Histology

276

(1)

Immunohistochemistry

276

(1)

Molecular Biology

276

(1)

Treatment

276

(1)

Clinical Course and Prognosis

276

(1)

Differential Diagnosis

277

(2)

Burkitt Lymphoma

279

(6)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Classification

279

(1)

Definition

279

(1)

Clinical Features

279

(1)

Histology

280

(1)

Immunohistochemistry

281

(1)

Molecular Biology

281

(1)

Treatment

282

(1)

Clinical Course and Prognosis

282

(1)

Differential Diagnosis

282

(1)

Comments

282

(3)

Mantle Cell Lymphoma

285

(4)

Christian A. Sander

Michael J. Flaig

Classification

285

(1)

Definition

285

(1)

Clinical Features

285

(1)

Histology

285

(1)

Immunohistochemistry

286

(1)

Molecular Biology

286

(1)

Treatment

286

(1)

Clinical Course and Prognosis

287

(1)

Differential Diagnosis

287

(2)

Waldenstrom Macroglobulinemia

289

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

289

(1)

Definition

289

(1)

Clinical Features

289

(1)

Histology

290

(1)

Immunohistochemistry

290

(1)

Molecular Biology

290

(1)

Treatment

291

(1)

Clinical Course and Prognosis

291

(1)

Differential Diagnosis

291

(1)

Comments

291

(2)

Other Forms of Cutaneous B-cell Lymphomas

293

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Subcutaneous B-cell Lymphoma

293

(2)

Classification

293

(2)

Cutaneous B-cell Lymphoma with Signet Ring-Cell Morphology

295

(2)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

295

(1)

Definition

295

(1)

Clinical Features

295

(1)

Histology

295

(1)

Immunohistochemistry

296

(1)

Molecular Biology

296

(1)

Treatment

296

(1)

Differential Diagnosis

296

(1)

Comments

296

(1)

IMMATURE HEMATOPOIETIC MALIGNANCIES

Blastic NK-Cell Lymphoma

297

(6)

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Gunter Burg

Classification

297

(1)

Definition

297

(1)

Clinical Features

297

(1)

Histology

297

(2)

Immunohistochemistry

299

(1)

Molecular Biology

299

(1)

Treatment

300

(1)

Clinical Course and Prognosis

300

(1)

Comments

301

(2)

Precursor Lymphoblastic Leukemia/Lymphoma

303

(8)

Precursor T-Lymphoblastic Leukemia/Lymphoma

303

(4)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

303

(1)

Definition

303

(1)

Clinical Features

303

(1)

Histology

304

(1)

Immunohistochemistry

304

(1)

Molecular Biology

304

(1)

Treatment

304

(1)

Clinical Course and Prognosis

304

(1)

Differential Diagnosis

304

(3)

Precursor B-Lymphoblastic Leukemia/Lymphoma

307

(4)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Classification

307

(1)

Definition

307

(1)

Clinical Features

307

(1)

Histology

308

(1)

Immunohistochemistry

309

(1)

Molecular Biology

309

(1)

Treatment

310

(1)

Clinical Course and Prognosis

310

(1)

Differential Diagnosis

310

(1)

Cutaneous Manifestations of Hodgkin Lymphoma

311

(6)

Marshall E. Kadin

Werner Kempf

Gunter Burg

Introduction

311

(1)

Secondary Involvement of the Skin by Systemic Hodgkin Lymphoma

311

(1)

Skin Disorders Associated with Systemic Hodgkin Lymphoma

312

(1)

HIV-Associated Hodgkin Lymphoma

312

(1)

Primary Cutaneous Hodgkin Lymphoma

312

(5)

Cutaneous Pseudolymphomas

317

(34)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Definition

317

(1)

Introduction

317

(2)

Cutaneous T-cell Pseudolymphoma

319

(6)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Lymphocytic Infiltration of Jessner-Kanof (Idiopathic Cutaneous T-cell Pseudolymphoma)

319

(2)

Palpable Migratory Arciform Erythema

321

(2)

Lymphomatoid Contact Dermatitis

323

(1)

Actinic Reticuloid

323

(1)

Persistent Nodular Arthropod-Bite Reactions

323

(2)

Cutaneous B-cell Pseudolymphoma

325

(6)

Gunter Burg

Werner Kempf

Dmitry V. Kazakov

Lymphadenosis Benigna Cutis

325

(1)

Clinical Features

325

(1)

Histology

326

(1)

Immunohistochemistry

327

(1)

Molecular Biology

328

(1)

Differential Diagnosis

328

(1)

Comments

328

(3)

Acral Pseudolymphomatous Angiokeratoma of Children

331

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

331

(1)

Clinical Features

331

(1)

Histological Features

331

(1)

Immunohistochemistry

332

(1)

Molecular Biology

333

(1)

Differential Diagnosis

333

(1)

Treatment

334

(1)

Clinical Course and Prognosis

334

(1)

Comments

334

(3)

Pseudolymphomatous Folliculitis

337

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Clinical Features

337

(1)

Histological Features

337

(1)

Immunohistochemistry

337

(1)

Molecular Biology

338

(1)

Differential Diagnosis

338

(1)

Treatment

338

(1)

Clinical Course

338

(1)

Comments

338

(3)

Cutaneous Inflammatory Pseudotumor

341

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Clinical Features

341

(1)

Histological Features

341

(2)

Immunohistochemistry

343

(1)

Molecular Biology

343

(1)

Differential Diagnosis

343

(1)

Treatment

344

(1)

Clinical Course

344

(1)

Comments

344

(1)

Castleman Disease

345

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

345

(1)

Clinical Features

345

(1)

Histology

345

(1)

Immunohistochemistry

346

(1)

Molecular Biology

346

(1)

Treatment

346

(1)

Clinical Course and Prognosis

347

(1)

Differential Diagnosis

347

(1)

Comments

348

(1)

Pseudolymphomatous Infiltrates in the Context of Other Skin Disorders

349

(2)

Gunter Burg

Werner Kempf

Parapsoriasis

351

(12)

Gunter Burg

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Historical Perspectives

351

(1)

Modern Perspectives

352

(1)

Commentary

352

(3)

Small Plaque Parapsoriasis

355

(4)

Gunter Burg

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Classification

355

(1)

Definition

355

(1)

Clinical Features

355

(1)

Histology

355

(1)

Immunohistochemistry

356

(1)

Molecular Biology

356

(1)

Treatment

357

(1)

Clinical Course and Prognosis

357

(1)

Differential Diagnosis

357

(2)

Large Plaque Parapsoriasis With and Without Poikiloderma

359

(4)

Gunter Burg

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Large Patch Type Without Poikiloderma

359

(1)

Large Patch Type With Poikiloderma

360

(3)

Cutaneous T-cell Lymphoproliferative Disorders of Unknown Significance

363

(10)

Gunter Burg

Werner Kempf

Papuloerythroderma of Ofuji

363

(4)

Definition

363

(1)

Clinical Features

363

(1)

Histology

364

(1)

Immunohistochemistry

364

(1)

Treatment

365

(1)

Clinical Course and Prognosis

365

(1)

Differential Diagnosis

365

(1)

Comments

365

(2)

Clonal T-cell Disorders

367

(6)

Werner Kempf

Dmitry V. Kazakov

Gunter Burg

Clonal Dermatitis

368

(1)

Lichen Planus and Psoriasis

368

(1)

Pityriasis Lichenoides

368

(2)

Persistent Pigmented Purpuric Dermatitis (PPPD)

370

(1)

Angiolymphoid Hyperplasia with Eosinophilia and Kimura Disease

371

(2)

Skin Involvement in Leukemias

373

(40)

Stanislaw Buechner

Introduction

373

(2)

Chronic Lymphocytic Leukemia, B-cell Type (B-CLL)

375

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

375

(1)

Histology

376

(1)

Immunohistochemistry

377

(1)

Molecular Biology

377

(2)

Chronic Lymphocytic Leukemia, T-cell Type (T-CLL)

379

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

379

(1)

Histology

380

(1)

Immunohistochemistry

381

(2)

Chronic Myeloid Leukemia (CML)

383

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

383

(1)

Histology

384

(1)

Immunohistochemistry

384

(3)

Hairy-Cell Leukemia (HCL)

387

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

387

(1)

Histology

388

(1)

Immunohistochemistry

389

(2)

Acute Lymphoblastic Leukemia (ALL)

391

(2)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

391

(1)

Histology

391

(1)

Immunohistochemistry

392

(1)

Acute (Myelo-) Monocytic Leukemia (AMoL, AMMoL)

393

(6)

Clinical Features

393

(2)

Histology

395

(1)

Immunohistochemistry

396

(3)

Acute Granulocytic (Myeloid) Leukemia (AML)

399

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

400

(1)

Histology

400

(1)

Immunohistochemistry

401

(2)

Granulocytic Sarcoma (Chloroma)

403

(4)

Stanislaw Buechner

Daniel W.P. Su

Clinical Features

403

(1)

Histology

404

(1)

Immunohistochemistry

404

(3)

Large Granular Lymphocyte Leukemias

407

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Chronic Neutrophilic Leukemia

411

(2)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Classification

411

(1)

Definition

411

(1)

Clinical Features

411

(1)

Histology

412

(1)

Immunohistochemistry

412

(1)

Laboratory Findings

412

(1)

Cytogenetics

412

(1)

Treatment

412

(1)

Clinical Course and Prognosis

412

(1)

Differential Diagnosis

412

(1)

Paraneoplastic Cutaneous Reactions in Leukemia and Lymphomas

413

(6)

Werner Kempf

Reinhard Dummer

Dmitry V. Kazakov

Gunter Burg

Definition

413

(1)

Classic Paraneoplastic Diseases

413

(1)

Acute Febrile Neutrophilic Dermatosis

413

(2)

Vasculitis

415

(1)

Pathogenesis

416

(1)

Treatment

416

(1)

Comment

416

(3)

Histiocytic Disorders

419

(42)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Langerhans Cell Histiocytosis (Histiocytosis X)

423

(8)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

423

(1)

Clinical Features

423

(4)

Histopathology

427

(1)

Immunohistochemistry

428

(1)

Electron Microscopy

428

(1)

Treatment

428

(3)

Indeterminate Cell Histiocytosis

431

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

431

(1)

Clinical Features

431

(1)

Histology

431

(1)

Immunohistochemistry

432

(1)

Electron Microscopy

432

(1)

Treatment

433

(1)

Clinical Course and Prognosis

433

(1)

Comments

433

(2)

Sinus Histiocytosis with Massive Lymphadenopathy

435

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

435

(1)

Clinical Features

435

(1)

Histology

436

(1)

Immunohistochemistry

437

(1)

Treatment

437

(1)

Clinical Course and Prognosis

437

(1)

Differential Diagnosis

438

(1)

Comments

438

(3)

Multicentric Reticulohistiocytosis (Lipoid Dermatoarthritis)

441

(6)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

441

(1)

Clinical Features

441

(1)

Histology

442

(1)

Immunohistochemistry

443

(1)

Treatment

443

(1)

Electron Microscopy

443

(1)

Clinical Course and Prognosis

444

(1)

Comments

444

(3)

Juvenile Xanthogranuloma

447

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

447

(1)

Clinical Features

447

(1)

Histology

448

(1)

Immunohistochemistry

448

(1)

Treatment

449

(1)

Clinical Course and Prognosis

449

(1)

Comments

450

(1)

Benign Cephalic Histiocytosis

451

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

451

(1)

Clinical Features

451

(1)

Histology

451

(1)

Immunohistochemistry

452

(1)

Electron Microscopy

452

(1)

Treatment

453

(1)

Clinical Course and Prognosis

453

(1)

Comments

453

(2)

Solitary Reticulohistiocytoma

455

(4)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Definition

455

(1)

Clinical Features

455

(1)

Histology

455

(1)

Immunohistochemistry

456

(1)

Electron Microscopy

456

(1)

Clinical Course and Prognosis

457

(1)

Comments

457

(2)

Malignant Histiocytic Tumors

459

(2)

Dmitry V. Kazakov

Gunter Burg

Werner Kempf

Introduction

459

(1)

Malignant Histiocytic Tumors of the Skin

459

(2)

Etiology and Pathogenesis of Cutaneous Lymphomas

461

(14)

Gunter Burg

Werner Kempf

Reinherd Dummer

Dmitry V. Kazakov

Frank O. Nestle

Antonio Cozzio

Sonja Michaelis

Udo Dobbeling

Introduction

461

(1)

Genetics Factors

461

(1)

Environmental Factors

462

(1)

Infectious Factors

462

(2)

Human T-cell Lymphotropic Viruses

462

(1)

Epstein--Barr Virus and Other Herpesviruses

463

(1)

Borrelia burgdorferi

463

(1)

Superantigens

463

(1)

Immunological Factors

464

(1)

Pathogenetic Models of Cutaneous Lymphomagenesis

465

(10)

The Thymus Bypass Model

465

(1)

A Multifactorial Concept of the Pathogenesis of Cutaneous Lymphomas

466

(9)

Therapy of Cutaneous Lymphomas

475

(54)

Introduction

475

(6)

Gunter Burg

Werner Kempf

Reinhard Dummer

Antonio Cozzio

Sonja Michaelis

Frank O. Nestle

Therapeutic Modalities

479

(2)

Topical Therapies

481

(16)

Gunter Burg

Reinhard Dummer

Werner Kempf

Sonja Michaelis

Philippa Golling

Frank O. Nestle

Nonaggressive Topical Therapies

481

(4)

Aggressive Topical Therapies

485

(12)

Systemic Therapies

497

(14)

Gunter Burg

Reinhard Dummer

Werner Kempf

Sonja Michaelis

Philippa Golling

Frank O. Nestle

Nonaggressive Systemic Therapies

497

(7)

Aggressive Systemic Therapies

504

(7)

Experimental Therapies

511

(14)

Gunter Burg

Reinhard Dummer

Werner Kempf

Frank O. Nestle

Topical Experimental Therapies

511

(3)

Systemic Experimental Therapies

514

(5)

Vaccination Therapy

519

(6)

Stage-Adjusted Treatment of Cutaneous Lymphomas: The Practical Approach

525

(4)

Gunter Burg

Reinhard Dummer

Werner Kempf

Sonja Michaelis

Philippa Golling

Frank O. Nestle

Cutaneous T-cell Lymphomas (CTCL)

525

(2)

Cutaneous B-cell Lymphomas

527

(2)

Prognosis

529

(18)

Gunter Burg

Werner Kempf

Monika Hess Schmid

Prognostic Parameters in Cutaneous Lymphomas

529

(14)

Prognostic Parameters in Cutaneous T-cell Lymphomas

529

(5)

Prognostic Parameters in Cutaneous B-cell Lymphomas

534

(3)

The Prognostic Index

537

(6)

Survival Rates in Cutaneous Lymphomas

543

(4)

Gunter Burg

Werner Kempf

Concepts, Misconceptions, and Controversies in Cutaneous Lymphomas

547

(4)

Gunter Burg

Who Was First?: There Will Always Be Somebody ``Before''

547

(1)

The Infinite Loop of Lymphoma Classification

547

(1)

Using the Same Words Does Not Mean Speaking the Same Language

548

(1)

The Emperor's New Clothes: Seeing Something That Is Not There

548

(1)

Pink and Blue vs. Red and Brown

548

(1)

What Makes the Lymphocyte Angry?

549

(1)

Which Target Do We Really Treat?

549

(2)

Index

551

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Cutaneous Lymphomas

Summary

Table of Contents

Supplemental Materials

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Cutaneous Lymphomas

Summary

Table of Contents

Supplemental Materials

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