Delivery Technologies for Biopharmaceuticals Peptides, Proteins, Nucleic Acids and Vaccines

, by Jorgensen, Lene; Nielson, Hanne Morck

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ISBN: 9780470723388 | 0470723386
Cover: Hardcover
Copyright: 12/21/2009

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Successful delivery of biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Delivery Technologies for Biopharmaceuticals is the first single-volume reference to describe the strategies to overcome the main barriers for successful delivery of all major classes of biopharmaceuticals--peptides, proteins, nucleic acids, and vaccines. With extensive case studies showing how the science has been put into practice, this essential introduction will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Preface page
List of Contributors
Introduction
Challenges in Delivery of Biopharmaceuticals the Need for Advanced Delivery Systems
Introduction
Overcoming Delivery Barriers
Drug Delivery Technologies and Excipients
Risks
Conclusion
References
Delivery of Biopharmaceuticals
Novel Formulation Approaches for Peptide and Protein Injectables
Introduction
Formulation Challenges
Chemical Modifi cation of Proteins and Peptides
Depot Delivery Systems
Other Delivery Systems
Conclusions
References
Novel Non-Injectable Formulation Approaches of Peptides and Proteins
Introduction
Intranasal Delivery of Peptide/Protein Drugs
Pulmonary Delivery of Peptide/Protein Drugs
Buccal Administration of Peptide/Protein Drugs
Oral Delivery of Peptide/Protein Drugs
Transdermal Delivery of Peptide/Protein Drugs
Conclusions
References
Chemical Vectors for Delivery of Nucleic Acid-Based Drugs
Introduction
Barriers to Delivery of Nucleic Acids
Major Classes of Delivery Vectors
Targeted Delivery
Triggered Release
Recent Clinical Trials Using Naked and Chemically Complexed Nucleic Acids
Conclusion
References
Viral Technology for Delivery of Nucleic Acids
Introduction
Barriers and Topological Requirements to Cellular Entry
Routes of Administration
Delivery Vector Requirements
Examples of Viral Delivery Technology
Conclusion
References
The Innate Immune Responses, Adjuvants and Delivery Systems
Introduction
Dendritic Cell Immunobiology
Antigen Capture
Particulate Antigen Delivery Systems
Signalling Receptors and the Role of Adjuvants
Conclusions
References
Delivery Technologies For Biopharmaceuticals
Lipid Nanoparticle-Based Systems for Delivery of Biomacromolecule Therapeutics
Introduction
Definitions and Properties of Solid Lipid Nanoparticles (SLNs)
Definitions and Properties of Lipid-Drug Conjugates (LDCs)
Administration, Delivery and Targeting
Toxicity and Safety
Applications for Biopharmaceuticals
Conclusions
References
Dendrimers in Delivery of Biopharmaceuticals
Introduction
Case I -- Application of Dendrimers in Delivery of Large Molecular Weight Drugs
Case II -- Application of Dendrimers in Gene Delivery
Case III -- Application of Dendrimers in Vaccine Delivery
Concluding Remarks
References
Peptides and Proteins
Modifi cation of Peptides and Proteins
Introduction
PEGylated Peptides and Proteins
Lipidization of Peptides and Proteins
Modifi cation of the Primary Structure of Peptides and Proteins
General Considerations on Processing and Characterization
Conclusions
References
Nanocarriers for the Delivery of Peptides and Proteins
Introduction
Polymeric Nanoparticles
In Situ
Depot Forming Systems
Conclusions
References
Polymer-Based Delivery Systems for Oral Delivery of Peptides and Proteins
Introduction
Advances in Oral Protein Delivery
Intestinal Considerations for Protein Absorption
Polymer-Based Delivery Systems for Oral Delivery of Proteins
Conclusions
References
Advanced Pulmonary Delivery of Peptides or Proteins Using Polymeric Particles
Introduction
Practical Issues in the Pulmonary Delivery of Peptides and Proteins
Polymeric Microparticles for Delivering Peptides and Proteins
Porous Microparticles
Polymeric Nanoparticles
Sustained or Controlled Release Issues in Polymeric Particle Formulations
Stability Issues of Peptides and Proteins in Particles
Toxicity Issues of Inhaled Particles
Conclusions
References
Nucleic Acids
Polymer Microparticles for Nucleic Acid Delivery
Introduction
Microparticles Based on Poly(Lactic-co-Glycolic Acids) (PLGA)
Other Types of Polymer Microparticles
Conclusions
References
Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics
Introduction
RNA Interference: Mechanism of Action
Lung Physiology
Animal Models
siRNA Delivery to Treat Pulmonary Diseases
siRNA-Induced Infl ammatory Response
Case Studies
Faster Drug for Unknown Bugs
Conclusions
References
Lipid-Based Formulations for siRNA Delivery
Introduction
Cationic Lipid-Based Delivery Systems for Nucleic Acid-Based Drugs
Neutral and Anionic Lipid-Based Drug Delivery Systems
Mechanisms of Internalization
Immune Activation
Conclusions
References
Cellular Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to Cell Penetrating Peptides
Introduction
Peptide Nucleic Acids (PNAs)
Cell Penetrating Peptides (CPPs)
Cellular Uptake Versus Bioavailability
PNA Conjugates
Efficacy Versus Effi ciency
Auxiliary Agents
In Vivo Activity of PNA Conjugates
Conclusions
References
DEAE-dextran-MMA Graft Copolymer for Non-Viral Delivery of DNA
Introduction
Theoretical
Materials and Methods
Conclusions
References
Vaccines
Liposomes in Adjuvant Systems for Parenteral Delivery of Vaccines
The Structural Basis of Liposomes
Key Characteristics Which Make Liposomes Advantagous as Vaccine Delivery Systems
Formulation Approaches to Improve Adjuvanticity and Enhance Immunological Targeting
Instability Considerations of Liposomes
Techniques to Formulate Long-Term Stable Liposome Formulations
Conclusion
References
Influenza Virosomes as Delivery Systems for Antigens
Introduction
A Case Study -- Antigen-Virosome Drug Delivery System
Methods
References
GRAZAX: An Oromucosal Vaccine for Treating Grass Pollen Allergy with Immunotherapy
Introduction
Specific Immunotherapy
Description of Grass Pollen Extract
Technologies of Fast Dissolving Tablets
Formulation of GRAZAX
Production of GRAZAX
Specifi cations and Analytical Procedures
Feasibility Study: Additional Analyses
Conclusions
References
Final Comments
Delivery Technologies for Biopharmaceuticals: A Critical Assessment
Introduction
Large Scale Production and Reproducibility
Safety Concerns
Cost-Benefit Ratio
Conclusion
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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Delivery Technologies for Biopharmaceuticals Peptides, Proteins, Nucleic Acids and Vaccines

Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Delivery Technologies for Biopharmaceuticals Peptides, Proteins, Nucleic Acids and Vaccines

Summary

Author Biography

Table of Contents

Supplemental Materials

Digital License