Reference provides comprehensive coverage of the latest advances in the development, preparation, and application of topical and transdermal therapeutic systems. Covers recent modalities for the management of psoriasis, hyperkeratosis, and acne, formulation strategies, and more.
Preface
iii
Contributors
ix
The Structure and Function of Skin
1
(40)
Kenneth A. Walters
Michael S. Roberts
Common Skin Disorders and Their Topical Treatment
41
(20)
C. Colin Long
Basic Mathematical Principles in Skin Permeation
61
(28)
Adam C. Watkinson
Keith R. Brain
Skin Transport
89
(108)
Michael S. Roberts
Sheree Elizabeth Cross
Mark A. Pellett
Methods for Studying Percutaneous Absorption
197
(74)
Keith R. Brain
Kenneth A. Walters
Adam C. Watkinson
Formulation Strategies for Modulating Skin Permeation
271
(48)
Adrian F. Davis
Robert J. Gyurik
Jonathan Hadgraft
Mark A. Pellett
Kenneth A. Walters
Dermatological Formulation and Transdermal Systems
319
(82)
Kenneth A. Walters
Keith R. Brain
Bioavailability and Bioequivalence of Dermatological Formulations
401
(98)
Christian Surber
Adrian F. Davis
Scale-up of Dermatological Dosage Forms: A Case for Multivariate Optimization and Product Homogeneity
499
(12)
Orest Olejnik
Bruce A. Firestone
Safety Considerations for Dermal and Transdermal Formulations
511
(18)
Peter J. Dykes
Anthony D. Pearse
Transdermal Delivery and Cutaneous Reactions
529
(20)
Jagdish Singh
Howard I. Maibach
Index
549
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