Disorders of Bone and Mineral Metabolism

The Second Edition of this comprehensive reference combines a strong scientific base with a clinical focus to address the principal disorders of bone and mineral metabolism, including osteoporosis, kidney stone formation, abnormal serum mineral levels, Paget's disease, and other conditions. The contributors explain the mechanisms underlying these disorders and provide succinct guidance on evaluation and management. This edition describes recently introduced drugs, thoroughly reviews powerful new treatments for osteoporosis and nephrolithiasis, and features completely rewritten chapters on stone formation. More than 500 illustrations complement the text and over 150 tables help readers find needed information at a glance.

Contributing Authors
Preface to First Edition
Preface to Second Edition
Normal Mineral Metabolism	p. 1
Renal Handling of Calcium and Phosphorus	p. 3
Physiology and Pathophysiology of Renal Magnesium Handling	p. 34
Intestinal Absorption of Calcium, Magnesium, and Phosphorus	p. 48
Parathyroid Hormone-Synthesis and Secretion	p. 74
Target Tissue Actions, Metabolism, and Assay of Parathyroid Hormone	p. 102
Parathyroid Hormone-related Protein	p. 129
Vitamin D: Synthesis, Metabolism, and Clinical Measurement	p. 157
Bone Structure and Biology	p. 175
Embryology, Anatomy, and Microstructure of Bone	p. 177
The Cell and Molecular Biology of Bone Formation	p. 199
Mechanisms of Biomineralization	p. 227
Mechanisms and Regulation of Bone Resorption by Osteoclastic Cells	p. 235
Biology, Chemistry, and Biochemistry of the Mammalian Growth Plate	p. 255
Bone Remodeling	p. 315
Mineral Metabolism During the Human Life Cycle	p. 345
Mineral Metabolism during Pregnancy and Lactation	p. 347
Bone and Mineral Metabolism during Childhood	p. 360
Integration of Calcium Metabolism in the Adult	p. 381
Introduction to Clinical Mineral Disorders	p. 397
Clinical and Laboratory Approach to the Patient with Disorders of Bone and Mineral Metabolism	p. 399
Bone Mass Measurement	p. 406
Radiologic Imaging of Metabolic Bone Disease	p. 428
Clinical Use of Bone Biopsy	p. 448
Physiologic and Pathogenetic Significance of Bone Histomorphometric Data	p. 469
Disorders of Serum Mineral Levels	p. 487
Hypercalcemic States: Differential Diagnosis and Acute Management	p. 489
Primary Hyperparathyroidism	p. 516
Disorders of Serum Minerals Caused by Cancer	p. 535
Hypercalcemia and Abnormal Vitamin D Metabolism	p. 557
The Hypocalcemic States	p. 568
Disorders of Phosphate and Magnesium Metabolism	p. 589
Disorders of Stone Formation	p. 617
Physical-Chemical Processes in Kidney Stone Formation	p. 619
Mechanisms of Stone Description and Dissolution	p. 629
Idiopathic Hypercalciuria	p. 673
Hyperoxaluric States	p. 698
Calcium Nephrolithiasis and Renal Tubular Acidosis	p. 717
Inhibitors and Promoters of Calcium Oxalate Crystallization: Their Relationship to the Pathogenesis and Treatment of Nephrolithiasis	p. 741
Noncalcium Urinary Calculi	p. 776
Disorders of Bone	p. 803
Primary Osteoporosis	p. 805
Treatment of Osteoporosis	p. 831
Secondary Forms of Osteoporosis	p. 847
Bone Disease in Chronic Renal Failure and after Renal Transplantation	p. 865
Bone Disease Resulting from Inherited Disorders of Renal Tubule Transport and Vitamin D Metabolism	p. 898
Bone Disease Due to Nutritional, Gastrointestinal and Hepatic Disorders	p. 918
Hereditary Metabolic and Dysplastic Skeletal Disorders	p. 937
Paget's Disease of Bone	p. 985
Primary Cystic and Neoplastic Diseases of Bone	p. 1021
Subject Index	p. 1051
Table of Contents provided by Blackwell. All Rights Reserved.

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Disorders of Bone and Mineral Metabolism

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