Drug Design of Zinc-Enzyme Inhibitors Functional, Structural, and Disease Applications

, by Supuran, Claudiu T.; Winum, Jean-Yves; Wang, Binghe

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780470275009 | 0470275006
Cover: Hardcover
Copyright: 8/17/2009

Rent

(Recommended)

$206.12

Term

Due

Price

Semester

Dec 12

$229.02

Quarter

Sep 7

$217.57

Short Term

Aug 13

$206.12

*This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping bag.
Buy New

Currently Available, Usually Ships in 24-48 Hours

$293.21
eBook

Available Instantly

Online: 1825 Days

Downloadable: Lifetime Access

*To support the delivery of the digital material to you, a digital delivery fee of $3.99 will be charged on each digital item.

$266.40*

The book gives students and young researchers a resource on zinc enzymes, some of which were intensively studied for more than six decades and translated into model success stories of the pharmaceutical industry. Up-to-date overviews on the major drug targets of the field are presented, showing the structural basis for catalysis, binding of inhibitors and activators, and their clinical applications. Emergent roles of some recently discovered isozymes in cancer, obesity, epilepsy, pain management, and malaria are also introduced, together with the most recent achievements in drug design from both academia and industry.

Preface	p. ix
Contributors	p. xi
Introduction	p. 1
Introduction to Zinc Enzymes as Drug Targets	p. 3
Drug Design of Carbonic Anhydrase Inhibitors and Activators	p. 13
Carbonic Anhydrases as Drag Targets: General Presentation	p. 15
Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors	p. 39
-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design	p. 73
Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs	p. 139
Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs	p. 155
Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents	p. 171
Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII	p. 193
Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX	p. 223
Drug Design of Antiobesity Carbonic Anhydrase Inhibitors	p. 241
Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition	p. 255
Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV	p. 273
Mechanism and Inhibition of the ß-Class and ¿-Class Carbonic Anhydrases	p. 285
Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design	p. 301
Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development	p. 323
Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria	p. 335
Inhibitors of Helicobacter pylori ¿ and ß-Carbonie Anhydrases as Novel Drugs for Gastroduodenal Diseases	p. 359
QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design	p. 375
Selectivity Issues in the Design of CA Inhibitors	p. 399
Bicarbonate Transport Metabolons	p. 415
Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors	p. 439
Drug Design Studies of Carbonic Anhydrase Activators	p. 473
Drug Desig of Matrix Metalloproteinase Inhibitors	p. 487
Matrix Metalloproteinases: An Overview	p. 489
MMP Inhibitors Based on Earlier Succinmide Strategies: From Early to New Approaches	p. 519
Drug Design of Sulfonylated MMP Inhibitors	p. 549
ADAMs and ADAMTs Selective Synthetic Inhibitors	p. 591
QSAR Studies of MMP Inhibitors	p. 647
Drug Design of Baxterial Zinc protease Inhigitors	p. 673
Bacterial Zinc Proteases as Orphan Targets	p. 675
Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors	p. 705
Clostridium histolyticum Collagenase Inhibitors in the Drug Design	p. 721
Other Bacterial Zinc Peptidases as Potential Drug Targets	p. 731
Drug Design Studies of Other Zinc-Containing Enzymes	p. 749
Angiotensin Converting Enzyme (ACE) Inhibitors	p. 751
P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucuriis Venom: Isolation and Possible Inhibition	p. 789
CaaX-Protein Prenyltransferase Inhibitors	p. 813
Histone Deacetylase Inhibitors	p. 859
Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII)	p. 881
Targeting HTV-1 Integrase Zinc Binding Motif	p. 911
Inhibitors of Histidinol Dehydrogenases as Antibacterial Agents	p. 937
Dihydroorotase Inhibitors	p. 951
APOBEC3G: A Promising Antiviral Target	p. 981
Index	p. 989
Table of Contents provided by Ingram. All Rights Reserved.

Please wait while the item is added to your bag...

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Drug Design of Zinc-Enzyme Inhibitors Functional, Structural, and Disease Applications

Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Drug Design of Zinc-Enzyme Inhibitors Functional, Structural, and Disease Applications

Summary

Author Biography

Table of Contents

Supplemental Materials

Digital License