Drug Transporters Molecular Characterization and Role in Drug Disposition

Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters

Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.

The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.

• Reflects the current state of the field and offers perspectives on future directions
• Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science
• Provides up-to-date information on drug transporter families, mechanisms, and clinical implications
• Includes extensive references and numerous figures and tables throughout

Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

Guofeng You, PhD, Distinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.

Marilyn E. Morris, PhD, SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.

List of Contributors

Preface

CHAPTER 1.  Overview of Drug Transporter Families
Guofeng You and Marilyn E. Morris

CHAPTER 2. Organic Cation and Zwitterion Transporters
Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini

CHAPTER 3. Multidrug and Toxin Extrusion Proteins
Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy

CHAPTER 4. Organic Anion Transporters (OATs)
Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam

CHAPTER 5. Organic Anion Transporting Polypeptides OATP
Rommel G. Tirona and Richard B. Kim

CHAPTER 6. Mammalian Oligopeptide Transporters
Stephen M. Carl,  Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.

CHAPTER 7. Monocarboxylic Acid Transporters
Marilyn E. Morris and Nisha V. Kwatra

CHAPTER 8. The Nucleoside Transporters CNTs and ENTs
Raj Govindarajan, Antonio López Quiñones, and Joanne Wang

CHAPTER 9. Bile Acid Transporters
Ebehiremen N. Ayewoh and  Peter W. Swaan

CHAPTER 10. The P-glycoprotein Multidrug Transporter
Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar

CHAPTER 11. Multidrug Resistance Proteins of the ABCC Subfamily
Anne T. Nies and Franziska Klein

CHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)
Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates

CHAPTER 13. Drug Transport in the Liver
Noora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer

CHAPTER 14. Drug Transport in the Brain
Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan

CHAPTER 15. Drug Transport in the Kidney
Douglas H. Sweet

CHAPTER 16. Drug transporters in the human intestine
Stefan Oswald

CHAPTER 17. Drug Transport in the Placenta
Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat

CHAPTER 18. Polymorphisms of drug transporters and clinical relevance
Tore B. Stage and Deanna L. Kroetz

CHAPTER 19. Ontogeny of Drug Transporters
Melanie A. Felmlee and Qing Zhang

CHAPTER 20.  Experimental Approaches for Studying Drug Transporters
Yusuke Masuo, Azusa Futatsugi, and Yukio Kato

CHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approaches
Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai

CHAPTER 22. In vitro-in vivo scale-up of drug transport activities
Kazuya Maeda and Yuichi Sugiyama

CHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and Toxicity
Matthew D. Harwood, Amin Rostami-Hodjegan,  and Sibylle Neuhoff

CHAPTER 24. Transporters as therapeutic targets in human diseases
Robert S. Jones and Eugene C. Chen

CHAPTER 25. Diet/Nutrient Interactions with Drug Transporters
Marilyn E. Morris and Tianjing Ren

Index

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