Dynamic Covalent Chemistry Principles, Reactions, and Applications

The first and only exhaustive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems

Dynamic Covalent Chemistry: Principles, Reactions, and Applications presents a comprehensive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems. It features contributions from a team of international scientists, grouped into three main sections covering the principles of dynamic covalent chemistry, types of dynamic covalent chemical reactions, and the latest applications of dynamic covalent chemistry (DC_vC) across an array of fields.

The past decade has seen tremendous progress in (DC_vC) research and industrial applications. The great synthetic power and reversible nature of this chemistry has enabled the development of a variety of functional molecular systems and materials for a broad range of applications in organic synthesis, materials development, nanotechnology, drug discovery, and biotechnology. Yet, until now, there have been no authoritative references devoted exclusively to this powerful synthetic tool, its current applications, and the most promising directions for future development. Dynamic Covalent Chemistry: Principles, Reactions, and Applications fills the yawning gap in the world literature with comprehensive coverage of:

• The energy landscape, the importance of reversibility, enthalpy vs. entropy, and reaction kinetics
• Single-type, multi-type, and non-covalent reactions, with a focus on the advantages and disadvantages of each reaction type
• Dynamic covalent assembly of discrete molecular architectures, responsive polymer synthesis, and drug discovery
• Important emerging applications of dynamic covalent chemistry in nanotechnology, including both material- and bio-oriented directions
• Real-world examples describing a wide range of industrial applications for organic synthesis, functional materials development, nanotechnology, drug delivery and more

Dynamic Covalent Chemistry: Principles, Reactions, and Applications is must-reading for researchers and chemists working in dynamic covalent chemistry and supramolecular chemistry. It will also be of value to academic researchers and advanced students interested in applying the principles of (DC_vC) in organic synthesis, functional materials development, nanotechnology, drug discovery, and chemical biology.

Edited by
WEI ZHANG, PhD, is a professor in the Department of Chemistry and Biochemistry at the University of Colorado, Boulder, USA. He has been an active researcher of dynamic covalent chemistry for over 15 years.

YINGHUA JIN, PhD, is a Senior Research Associate, affiliated with both the Department of Chemical and Biological Engineering and the Department of Chemistry and Biochemistry at the University of Colorado, Boulder, USA.

List of Contributors

1. Principles of Dynamic Covalent Chemistry

2. Dynamic Combinatorial Libraries

3.  Shape-Persistent Macrocycles through Dynamic Covalent Reactions

4. Chapter 4. Organic Cages through Dynamic Covalent Reactions

5. Orthogonal Dynamic Covalent and Non-covalent Reactions

6. Self-Sorting through Dynamic Covalent Chemistry.

7. Dynamic Covalent Chemistry for Synthetic Molecular Machines

8. Responsive Dynamic-Covalent Polymers

9. Responsive Dynamic-Covalent Polymers

10. Emerging Applications of Dynamic Covalent Chemistry From Macro- to Nanoscopic Length Scales

Index

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