Early Clinical Intervention and Prevention in

Leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific (proposed) syndrome of liability (schizotaxia)-and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia.

Preface

v

Contributors

xi

Value-Added eBook/PDA

xiv

Part I. The Etiology and Genetics of Schizophrenia

The Genetic Basis of Schizophrenia

3

(20)

Stephen V. Faraone

Stephen J. Glatt

Levi Taylor

Early Environmental Determinants of Schizophrenia

23

(20)

Jason Schiffman

John Carter

Ricardo A. Machon

Sarnoff Mednick

Obstetric Risk Factors for Schizophrenia and Their Relationship to Genetic Predisposition: Following Ariadne's Double-Stranded Thread Through Early Development

43

(32)

Stefano Marenco

Daniel R. Weinberger

Part II. The Vulnerability to Schizophrenia

The Nature of the Prodrome in Schizophrenia

75

(18)

Jaak Rakfeldt

Thomas H. McGlashan

The Nature of Schizotaxia

93

(22)

Stephen V. Faraone

Ming T. Tsuang

Sarah I. Tarbox

A Neuropsychological Perspective on Vulnerability to Schizophrenia: Lessons From High-Risk Studies

115

(18)

Allan F. Mirsky

Connie C. Duncan

Neurocognitive Deficits in the Biological Relatives of Individuals With Schizophrenia

133

(26)

William S. Kremen

Anne L. Hoff

The Nature and Origin of Socioemotional Deficits in Schizophrenia

159

(20)

Elaine Walker

Karen M. Hochman

Neuroimaging Studies of Nonpsychotic First-Degree Relatives of People With Schizophrenia: Toward a Neurobiology of Vulnerability to Schizophrenia

179

(32)

Larry J. Seidman

Heidi E. Wencel

Colm McDonald

Robin M. Murray

Ming T. Tsuang

Neurophysiological Endophenotypes in Early Detection of Schizophrenia

211

(14)

Marina Myles-Worsley

Is the Development of Schizophrenia Predictable?

225

(30)

Paola Dazzan

Eugenia Kravariti

Paul Fearon

Robin M. Murray

Part III. Early Intervention and Prevention of Schizophrenia

Prevention of Schizophrenia and Psychotic Behavior: Definitions and Methodological Issues

255

(30)

C. Hendricks Brown

Stephen V. Faraone

The Treatment of Schizotaxia

285

(18)

Ming T. Tsuang

Sarah I. Tarbox

Levi Taylor

William S. Stone

Treatment of the Schizophrenia Prodrome

303

(22)

Barbara Cornblatt

Todd Lencz

Christopher Smith

Andrea Auther

The Role of Genetic Counseling

325

(14)

Debby W. Tsuang

Stephen V. Faraone

Ming T. Tsuang

Part IV. Challenges for the Near Future

The Biology of Schizotaxia

339

(16)

William S. Stone

Stephen J. Glatt

Stephen V. Faraone

Molecular Medicine and the Prospects for Prevention and Early Intervention in Schizophrenia

355

(12)

William T. Carpenter, Jr.

James I. Koenig

Index

367

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Early Clinical Intervention and Prevention in Schizophrenia

Summary

Table of Contents

Supplemental Materials