Edhf 2000

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ISBN: 9780415269049 | 0415269040
Cover: Hardcover
Copyright: 11/29/2001

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Understanding the nature and role of endothelium-derived hyperpolarizing factor appears to be crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion and other vascular disorders.EDHF 2000 comprises the proceedings of the Third International Symposium on endothelium-dependent hyperpolarizations. The first two meetings established a role for EDHF and other chemical factors involved in endothelium-dependent hyperpolarizations. These proceedings focus upon the role of gap junctions in cardiovascular responses and investigate the chemical identity of EDHF. Additional chapters on Physiology, Hormonal Modulation and Pathological Changes are also included.EDHF 2000 will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.

Preface	p. xi
Acknowledgements	p. xii
Contributors	p. xiii
What do gap junctions do anyway?	p. 1
Cardiovascular gap junctions: functional diversity, complementation and specialization of connexins	p. 14
Endothelium and smooth muscle pathways for conduction along resistance microvessels	p. 22
Membrane potential and calcium responses evoked by acetylcholine in submucosal arterioles of the guinea-pig small intestine	p. 32
The effects of ouabain, 18[alpha]-glycyrrhetinic acid and connexin-mimetic peptides on intercellular communication in cells expressing a Cx43-GFP chimeric protein	p. 41
Role of gap junctions in endothelium-dependent hyperpolarizations	p. 53
Heterogeneity of EDHF-type relaxations of rabbit and rat arteries analysed with peptides homologous to the extracellular loops of connexins 37, 40 and 43	p. 62
Myoendothelial and circumferential spread of endothelium-dependent hyperpolarization in coronary arteries	p. 75
Direct myoendothelial contacts in human pulmonary microvessels	p. 87
Role of gap junctional communication in EDHF-mediated responses and mechanisms of K[superscript +]-induced dilatations	p. 95
Comparison of [alpha] and [beta] isoforms of glycyrrhetinic acid and carbenoxolone as inhibitors of EDHF-type relaxation	p. 102
Inhibitory effect of 18-[beta]-glycyrrhetinic acid on the relaxation induced by acetylcholine in the rat aorta	p. 113
A central role for endothelial cell potassium channels in EDHF-mediated responses	p. 118
Could the EDHF be K[superscript +] in porcine coronary arteries?	p. 126
Nitro-L-arginine/indomethacin-resistant relaxations to acetylcholine in small gastric arteries of the rat: Effect of ouabain plus Ba[superscript 2+] and relation to potassium ions	p. 136
Effects of barium, ouabain and K[superscript +] on the resting membrane potential and endothelium-dependent responses in rat arteries	p. 146
EDHF and potassium: blockade of chloride channels reveals relaxations of rat mesenteric artery to potassium	p. 156
Cytochrome P450 2C--a source of EDHF and reactive oxygen species in the porcine coronary artery	p. 167
Cortisol increases EDHF-mediated relaxations in porcine coronary arteries and up-regulates the expression of cytochrome P450 2C9	p. 173
An arachidonic acid metabolite(s) produced by the endothelial cytochrome P450 isoform, CYP3A4, relaxes the lingual artery of the monkey via K[superscript +] channel opening	p. 180
EDHF-mediated responses induced by bradykinin in the porcine coronary artery	p. 187
Epoxyeicosatrienoic acid release mediates nitric oxide-independent dilatation of rat mesenteric vessels	p. 195
Epoxyeicosatrienoic acid and endothelium-dependent hyperpolarization in porcine coronary arteries	p. 207
Lipoxygenase-derived metabolites of arachidonic acid are not involved in the endothelium-dependent hyperpolarization to acetylcholine in the carotid artery of the guinea-pig	p. 214
Cytochrome P450 isoforms in the brain encode cell specific hyperpolarizing factors with a common mechanism of action	p. 222
Expression of recombinant cytochrome P450 epoxygenase in rat brain	p. 228
Identification of 11,12,15-trihydroxyeicosatrienoic acid as the mediator of acetylcholine- and arachidonic acid-induced relaxations in the rabbit aorta	p. 239
Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice	p. 249
Components of the potassium currents underlying the actions of endothelium-derived hyperpolarizing factor in arterioles	p. 259
Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse	p. 270
Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS -/- and +/+ mice	p. 274
EDHF, which is not NO, is a major endothelium-dependent vasodilator in mice	p. 284
Prostacyclin and iloprost in the isolated carotid artery of the guinea-pig	p. 294
Role of charybdotoxin/apamin sensitive K[superscript + subscript Ca] channels in pulsatile perfusion-mediated coronary vasodilatation in vivo	p. 304
Essential role of estrogen in the EDHF-mediated responses of mesenteric arteries from middle-aged female rats: possible contribution of gap junctional protein connexin43	p. 313
Endothelium-derived hyperpolarizing factor (EDHF) and utero-feto-placental circulation in the rat	p. 323
Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite impairment of the nitric oxide pathway in porcine coronary arteries with regenerated endothelium	p. 332
Mechanisms underlying the vasodilatation caused by bradykinin in essential hypertensive patients	p. 341
Influence of diabetes on endothelium-dependent responses in mesenteric and femoral arteries of rats	p. 352
Folate restores the NO synthase- and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes	p. 360
Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries	p. 370
Critical limb ischemia results in different types of endothelial dysfunction depending on the vascular bed studied	p. 376
Potentiated EDHF-mediated dilatations in the rat middle cerebral artery following ischemia/reperfusion	p. 388
The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aorta is resistant to ionized radiation	p. 400
Inhibition of converting enzyme prevents the age-related decline in endothelium-dependent hyperpolarization	p. 410
Effects of a converting enzyme inhibitor, an AT[subscript 1]-receptor antagonist and their combination on endothelial dysfunction in hypertension	p. 417
EDHF: gap junction or chemical? and many other questions	p. 424
References	p. 430
Index	p. 472
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Edhf 2000

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