Endocrine Facets of Ageing

Social and medical developments have recently led to a dramatic increase in life expectancy. This has inspired the study of organismic changes associated with healthy ageing, in particular the erosion of homeostatic capabilities in multiple endocrine systems. This book reviews advances in the understanding of endocrine facets of ageing. It considers the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal, addressing the influence of external factors on the rates of progression of endocrine sequelae in ageing, the mechanisms that underlie the disarray of endocrine axes in ageing, and the implications of therapeutic reconstitution of hormones in ageing. This book: Considers the mechanisms of ageing and hormonal changes that occur with age. Discusses healthy ageing and the relationships between hormonal changes and pathophysiological conditions such as atherosclerosis and age-related bone loss. Draws together contributions from basic and clinical research, to identify and stimulate promising new research directions.

Derek J. Chadwick and Jamie A. Goode are editors for Endocrine Facets of Ageing and other scientific titles.

Chair's Introduction (J.D. Veldhuis)

Endocrine aspects of healthy ageing in men(A.W. van den Beld and S.W.J. Lamberts)

Ageing, stress and the brain (B.J. Carroll)

Alterations in the ageing corticotropic stress-response axis (P. Bjorntorp)

Male reproductive ageing: using the Brown Norway rat as a model for man (C. Wang et al)

Male reproductive ageing: human fertility, androgens and hormone dependent disease (D.J. Handelsman)

Mechanisms of conjoint failure of the somatotropic and gonadal axes in ageing men (J.D. Veldhuis et al)

Effects of growth hormone and insulin-like growth factor 1 deficiency on ageing and 1ongevity (Z. Laron)

The role of the insulin-like growth factor 1 and insulin in ageing and atherosclerosis (A. Ruiz-Torres)

The ageing female reproductive axis -1 Henry G. Burger et al)

The ageing female reproductive axis II: ovulatory changes with perimenopause (J. C. Prior)

The thyroid axis in ageing (H Leitolf et al)

Critical illness as a model of hypothalamic ageing (G. Van den Berghe and S.M. Shalet)

Glucose tolerance, glucose utilization and insulin secretion in ageing (D.Elahi et al)

Endocrine causes of age-related bone loss and osteoporosis (B.L. Riggs)

Ageing and water homeostasis (D. Robertson et al)

Summing Up (J.D. Veldhuis)

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Endocrine Facets of Ageing

Summary

Author Biography

Table of Contents

Supplemental Materials