The Endoplasmic Reticulum

The endoplasmic reticulum (ER) is a network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER.

The volume reviews the architecture of the ER and the ways in which it interacts with other organelles. The consequences for metabolic health and neurodegeneration are also considered. It is thus an essential reference for cell biologists, as well as physiologists and pathologists interested in understanding the role of the ER in disease.

(Preliminary)

Preface

1) Beyond the Kennedy Pathway: Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum
Robert V. Farese Jr. and Tobias C. Walther
2) Endoplasmic Reticulum-Associated Protein Degradation
Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho
3) The Role of Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases
Satarupa Bhaduri, Nicola Scott, and Sonya E. Neal
4) The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization
Michael J. McKenna and Sichen Shao
5) Mechanism of Protein Translocation by the Sec61 Translocon Complex
Samuel Itskanov and Eunyong Park
6) The Biogenesis of Multipass Membrane Proteins
Luka Smalinskait and Ramanujan S. Hegde
7) A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum
Alina Guna, Masami Hazu, Giovani Pinton Tomaleri, and Rebecca M. Voorhees
8) Post-Translational Regulation of HMG CoA Reductase
Youngah Jo and Russell A. DeBose-Boyd
9) Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes
Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda
10) ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophagy
Haruka Chino and Noboru Mizushima
11) ER Membrane Contact Sites, Lipid Transport, and Neurodegeneration
Andrs Guilln-Samander and Pietro De Camilli
12) Sorting and Export of Proteins at the Endoplasmic Reticulum
I. Raote, S. Saxena and Vivek Malhotra
13) Structural Diversity Within the Endoplasmic ReticulumFrom the Micron Scale to the Nanoscale
Christopher J. Obara, Andrew S. Moore, and Jennifer Lippincott-Schwartz
14) Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis
Xiao Wang and Xiao-Wei Chen
15) The Role of ER Architecture in Metabolic Health and Disease
Ana Paula Arruda and Gne Parlakgl
16) Evolutionary Aspects of the Unfolded Protein Response
Kazutoshi Mori
17) Cholesterol Transport to the Endoplasmic Reticulum
John P. Kennelly and Peter Tontonoz
18) Structure and Function of the Nuclear Pore Complex
Stefan Petrovic, George W. Mobbs, Christopher J. Bley, Si Nie, Alina Patke, and Andr Hoelz
19) AMPylation and ER Protein Folding Homeostasis
Luke A. Perera and David Ron
20) Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
Gary Ruvkun and Nicolas Lehrbach

Index