J.W. Goethe Univ., Frankfurt, Germany. Reviews issues of molecular and cell biology, as well as clinical aspects of the complex effects of environmental stressors and free radicals on the body. Begins at the molecular and cellular level, proceeding to examine the eye, skin, and lung as separate target organs. For researchers.
Series Introduction
iii
Lester Packer
Enrique Cadenas
Preface
vii
Contributors
xiii
I. Molecular and Cellular Aspects of Prooxidant Environmental Xenobiotics
Free Radical Reactions in Human Disease
1
(16)
Barry Halliwell
Radicals and Inflammation: Mediators and Modulators
17
(36)
Claire A. Davies
David R. Blake
Paul G. Winyard
Autoimmunity Caused by Oxidizing Foreign Compounds
53
(28)
Kaye H. Kilburn
Role of Oxidative Stress in Chemical Carcinogenesis
81
(22)
James E. Klaunig
Lisa M. Kamendulis
Proposed Mechanisms of Arsenic Toxicity Carcinogenesis
103
(12)
Michael I. Luster
Petia P. Simeonova
Redox Regulation of Gene Expression and Transcription Factors in Response to Environmental Oxidants
115
(20)
Hiroshi Masutani
Akira Nishiyama
Yong-Won Kwon
Yong-Chul Kim
Hajime Nakamura
Junji Yodoi
II. Target Organs of Environmental Oxidants: Lung
Cigarette Smoking and Pulmonary Oxidative Damage
135
(22)
Ching K. Chow
Health Effects of Diesel Exhaust and Diesel Exhaust Particles
157
(28)
Masaru Sagai
Takamichi Ichinose
The Role of Free Radicals in Asbestos- and Silica-Induced Fibrotic Lung Diseases
185
(18)
Arti Shukla
Cynthia R. Timblin
Brooke T. Mossman
Andrea Hubbard
Reactive Oxygen Species and Silica-Induced Carcinogenesis
203
(22)
Xianglin Shi
Min Ding
Fei Chen
Val Vallyathan
Vince Castranova
Atmospheric Oxidants and Respiratory Tract Surfaces
225
(12)
Carroll E. Cross
Samuel Louie
Sunye Kwack
Pat Wong
Sharanya Reddy
Albert van der Vliet
III. Target Organs of Environmental Oxidants: Skin
Redox Modulation and Oxidative Stress in Dermatotoxicology
237
(34)
Jurgen Fuchs
Maurizio Podda
Thomas Zollner
Dermatotoxicology of Environmental and Occupational Chemical Hazards: Agents and Action
271
(48)
Jurgen Fuchs
Photooxidative Stress in Skin and Regulation of Gene Expression
319
(16)
Lee Ann Laurent-Applegate
Stefan Schwarzkopf
Ozone Stress in the Skin Barrier
335
(10)
Stefan U. Weber
Lester Packer
Immunotoxicity of Environmental Agents in the Skin
345
(20)
Santosh K. Katiyar
Hasan Mukhtar
IV. Target Organs of Environmental Oxidants: Eye
Environmental Stressors and the Eye
365
(16)
John R. Trevithick
Kenneth P. Mitton
Free Radicals and Aging of Anterior Segment Tissues of the Eye
381
(42)
Keith Green
The Role of Ocular Free Radicals in Age-Related Macular Degeneration
423
(34)
Paul S. Bernstein
Nikita B. Katz
Nutritional Influences on Risk for Cataract
457
(32)
Allen Taylor
Index
489
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