Epilepsy and the Interictal State Co-morbidities and Quality of Life

Epilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day.

Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy. Each chapter employs a standard structure providing background, epidemiology, pathophysiology, etiology, diagnosis, treatment, prognosis and further practical advice.

From an international team of expert editors and contributors, Epilepsy and the Interictal State is a valuable resource for specialist epileptologists and neurologists, as well as for neurosurgeons, neurology nurses, psychiatrists, family physicians and general practitioners.

Erik K. St Louis, Department of Neurology, Mayo Clinic, Rochester, MN, USA

David M. Ficker, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA

Terence J. O’Brien, Departments of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic, Australia

List of contributors, ix

Foreword, xiii

Section I: Quality of life and the interictal state in epilepsy

1 Quality of life in epilepsy: the key importance of the interictal state, 3
David M. Ficker

2 Comorbidities in epilepsy: range and impact, 7
J. Layne Moore and John O. Elliott

3 Epilepsy, comorbidities, and consequences: implications for understanding and combating stigma, 15
Rosemarie Kobau, Colleen K. DiIorio, Nancy J. Thompson, Yvan A. Bamps, and Erik K. St. Louis

Section II: Cognition and epilepsy

4 Causes and types of cognitive domain impairments in epilepsy, 29

Impairment of consciousness in epilepsy, 31
Luigi Maccotta, Clemente Vega, and R. Edward Hogan

Ictal cognitive impairments due to nonconvulsive status epilepticus, 38
Elizabeth Waterhouse

Memory and dysexecutive impairments in epilepsy, 45
Erik K. St. Louis and Ashley M. Enke

Attention deficit/hyperactivity disorder, disordered attention, and epilepsy, 63
David W. Dunn and William G. Kronenberger

Behavioral and developmental disorders in epilepsy, 68
Michael Smith and Esmeralda L. Park

5 Cognitive effects of epilepsy therapies, 74
Beth A. Leeman and Kimford J. Meador

6 Autism and epilepsy, 88
Vladimýr Komárek

7 Cognitive rehabilitation strategies in epilepsy, 94
Cher Stephenson and Robert D. Jones

Section III: Adverse effects of epilepsy therapies

8 Adverse effects in epilepsy: recognition, measurement, and taxonomy, 103
Frank G. Gilliam, Laura S. Snavely, and Piero Perucca

9 Clinically important antiepileptic drug interactions and their influence on adverse effects in epilepsy, 110
Frank M.C. Besag and Philip N. Patsalos

10 Minimizing the adverse effects of epilepsy therapies: principles and practice, 120
Erik K. St. Louis

11 Idiosyncratic adverse side effects of antiepileptic drugs: risk, prevention, and counseling, 127
Mary L. Zupanc and Lily H. Tran

12 Antiepileptic drug therapy and fetal development, 136
Frank J.E. Vajda

Section IV: Mood state, psychiatric comorbidity, and epilepsy

13 Mood state, anxiety, and psychosis in epilepsy, 147
Michael Salzberg

14 The contribution of sleep and anxiety disorders to quality of life in people with epilepsy, 159
Dee Snape, Ann Jacoby, and Gus Baker

15 Epilepsy and personality, 171
Christopher Turnbull, Simon Jones, Sophia J. Adams, and Dennis Velakoulis

16 Psychogenic attacks and epilepsy, 183
Bláthnaid McCoy and Selim R. Benbadis

Section V: General health and epilepsy 17

Obesity and epilepsy, 195
Sandra J. Petty and Alison M. Pack

18 Epilepsy in the elderly: vascular disease, the aging brain, and selection of appropriate therapies, 203
Katherine H. Noe and Joseph I. Sirven

19 Balance disorders and falls in epilepsy, 216
Sandra J. Petty, Keith D. Hill, and John D. Wark

20 Bone health in epilepsy, 224
Sandra J. Petty, and John D. Wark

21 Sleep and epilepsy, 230
Irakli Kaolani and Erik K. St. Louis

22 Use of complementary and alternative medicine in epilepsy, 241
Dana Ekstein and Steven C. Schachter

23 Epilepsy and alcohol and substance abuse, 252
Ekrem Kutluay and Jonathan C. Edwards

24 Driving, employment, and related issues in epilepsy, 258
Kristine Ziemba and Joe Drazkowski

Index, 267

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