Erythropoietins, Erythropoietic Factors, and

This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed.This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.

List of contributors	p. VII
Preface to the first edition	p. IX
Preface to the second edition	p. XIII
Abbreviations	p. XV
Background
Erythropoiesis: an overview	p. 3
Regulation of endogenous erythropoietin production	p. 19
Biology of erythropoietin	p. 41
Erythropoiesis - genetic abnormalities	p. 61
Erythropoiesis-stimulating agents
Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin	p. 77
Commercial production of recombinant erythropoietins	p. 87
Biosimilar epoetins	p. 105
New molecules and formulations	p. 115
Erythropoietin receptor
Structural basis for the signal transduction of erythropoietin	p. 143
Intracellular signaling by the erythropoietin receptor	p. 155
Mechanism of erythropoietin receptor activation	p. 175
Clinical utility
Pharmacokinetics of erythropoiesis-stimulating agents	p. 199
Use of erythropoietic stimulating agents in the setting of renal disease	p. 225
Abuse of recombinant erythropoietins and blood products by athletes	p. 249
Role and regulation of iron metabolism in erythropoiesis and disease	p. 279
Nonhematopoietic effects of erythropoiesis-stimulating agents	p. 299
Index	p. 319
Table of Contents provided by Ingram. All Rights Reserved.

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Erythropoietins, Erythropoietic Factors, and Erythropoiesis

Summary

Table of Contents

Supplemental Materials